Q3TX08

PR
Gene name
Trmt1 (D8Ertd812e)
Protein name
tRNA (guanine(26)-N(2))-dimethyltransferase
Names
tRNA 2,2-dimethylguanosine-26 methyltransferase, tRNA(guanine-26,N(2)-N(2)) methyltransferase, tRNA(m(2,2)G26)dimethyltransferase
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:212528
EC number
2.1.1.216: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-162 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3TX08

Entry ID Method Resolution Chain Position Source
AF-Q3TX08-F1 Predicted AlphaFoldDB

No variants for Q3TX08

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q3TX08

No associated diseases with Q3TX08

3 regional properties for Q3TX08

Type Name Position InterPro Accession
domain RNA-binding, CRM domain 205 - 301 IPR001890-1
domain RNA-binding, CRM domain 359 - 456 IPR001890-2
domain RNA-binding, CRM domain 570 - 670 IPR001890-3

Functions

Description
EC Number 2.1.1.216 Methyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
tRNA (guanine-N2-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing guanine = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine.
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
tRNA N2-guanine methylation The process whereby a guanine in a tRNA is methylated at the N2 position of guanine.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q7Z2T5 TRMT1L TRMT1-like protein Homo sapiens (Human) PR
Q9NXH9 TRMT1 tRNA (guanine(26)-N(2))-dimethyltransferase Homo sapiens (Human) PR
Q9LFU5 At5g15810 Probable tRNA (guanine(26)-N(2))-dimethyltransferase 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SRU7 At3g02320 Probable tRNA (guanine(26)-N(2))-dimethyltransferase 2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSLARTILWL SRPLRPAHSL CRAQFMERKA QKPPSPPAME NGTRFCEERP PADPVATVTE
70 80 90 100 110 120
GAAKIVFPSA NEVFYNPVQE FNRDLTCAVI TEFARIHLGA KGIQIKVPGE KDSEKIAVDL
130 140 150 160 170 180
SDQEEETAGK NENLAPGDWP RTAAVGEICE EGLRVLEGLA ASGLRSIRFA LEVPGLQSVV
190 200 210 220 230 240
ANDASARAVE LMHRNVELNG VAHLVQPNQA DARMLMYQHQ KAPERFDVID LDPYGSPAPF
250 260 270 280 290 300
LDAAVQAVSD GGLLCVTCTD MAVLAGNSGE TCYSKYGAMA LKSRACHEMA LRIVLHSLDL
310 320 330 340 350 360
HANCYQRYIV PLLSISADFY IRVFVRVFTG QAKVKSSASK QALVFQCVGC GAFYLQRLGK
370 380 390 400 410 420
ASGDPGGRIK FSAACGPPVT PECEHCGQRH QLGGPMWAEP IHDLDFVGRV LDAVTTNPGR
430 440 450 460 470 480
FHTSMRIQGV LSVVTEELPD VPLYYTLDQL SSTIHCNTPR LLQLRSALLH AGFRVSLSHA
490 500 510 520 530 540
CKNAVKTDAP PEALWDIMRC WEKECPVKRE RLSESSPAFR ILAVEPRLKA NFNIREDANP
550 560 570 580 590 600
SSRQRGLKRF QANPEANWGP RPRARPGGKA ASEDLAGRRR LLQNKRKEPA EDPAQRAARL
610 620 630 640 650 660
KTFPCKRFKE GTCQLGDQCC YSHSPAAPVA SGDIPIEECP ETTTKISPGP KAAAGGIPGP
GVD