Q9SHZ0

PR
Gene name
DEGP4 (At1g65640, F1E22.2, F5I14.17)
Protein name
Protease Do-like 4, mitochondrial
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G65640
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

11-86 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9SHZ0

Entry ID Method Resolution Chain Position Source
AF-Q9SHZ0-F1 Predicted AlphaFoldDB

129 variants for Q9SHZ0

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH01473668 8 T>R No 1000Genomes
tmp_1_24413500_C_A 10 A>S No 1000Genomes
ENSVATH05071745 16 L>* No 1000Genomes
tmp_1_24413464_C_T 22 G>R No 1000Genomes
ENSVATH05071744 24 R>C No 1000Genomes
tmp_1_24413449_G_A 27 P>S No 1000Genomes
ENSVATH00124482 37 Q>H No 1000Genomes
ENSVATH05071743 37 Q>L No 1000Genomes
ENSVATH14420834 42 H>Y No 1000Genomes
ENSVATH00124481 44 S>R No 1000Genomes
ENSVATH13736026 46 S>* No 1000Genomes
ENSVATH05071742 46 S>T No 1000Genomes
ENSVATH05071741 50 S>T No 1000Genomes
ENSVATH05071740 51 G>E No 1000Genomes
ENSVATH05071739 53 D>Y No 1000Genomes
ENSVATH00124480 62 N>H No 1000Genomes
ENSVATH13736025 65 S>F No 1000Genomes
ENSVATH05071738 67 S>F No 1000Genomes
ENSVATH01473666 67 S>P No 1000Genomes
ENSVATH05071737 70 F>L No 1000Genomes
ENSVATH05071736 72 V>L No 1000Genomes
tmp_1_24413298_T_G 77 K>T No 1000Genomes
tmp_1_24413293_A_C 79 F>V No 1000Genomes
tmp_1_24413280_C_T 83 S>N No 1000Genomes
ENSVATH13736024 85 P>L No 1000Genomes
tmp_1_24413226_C_T 101 G>D No 1000Genomes
ENSVATH13736021 104 F>C No 1000Genomes
tmp_1_24413096_C_G 115 A>P No 1000Genomes
ENSVATH00124479 117 V>I No 1000Genomes
ENSVATH01473665 121 H>Q No 1000Genomes
ENSVATH14420832 125 Q>L No 1000Genomes
ENSVATH13736020 129 H>Y No 1000Genomes
ENSVATH13736019 137 A>V No 1000Genomes
tmp_1_24413020_C_T 140 R>Q No 1000Genomes
ENSVATH05071732 141 A>T No 1000Genomes
ENSVATH13736018 142 I>S No 1000Genomes
ENSVATH14420831 154 D>E No 1000Genomes
tmp_1_24412967_A_G 158 F>L No 1000Genomes
ENSVATH13736017 159 W>* No 1000Genomes
ENSVATH14420830 167 L>F No 1000Genomes
tmp_1_24412939_A_T 167 L>H No 1000Genomes
ENSVATH14420829 168 G>R No 1000Genomes
ENSVATH05071731 174 D>E No 1000Genomes
ENSVATH05071730 179 V>I No 1000Genomes
ENSVATH01473663 182 Y>N No 1000Genomes
ENSVATH13736012 184 T>A No 1000Genomes
tmp_1_24412799_T_C 187 D>G No 1000Genomes
tmp_1_24412796_C_T 188 S>N No 1000Genomes
tmp_1_24412731_T_C 210 T>A No 1000Genomes
ENSVATH05071725 212 L>F No 1000Genomes
ENSVATH13736011 214 I>V No 1000Genomes
tmp_1_24412692_C_T 223 G>R No 1000Genomes
tmp_1_24412671_T_C 230 I>V No 1000Genomes
ENSVATH05071723 238 V>I No 1000Genomes
tmp_1_24412637_T_C 241 Q>R No 1000Genomes
ENSVATH05071722 254 P>A No 1000Genomes
ENSVATH01473656 264 A>G No 1000Genomes
ENSVATH01473656 264 A>V No 1000Genomes
ENSVATH01473655 265 V>F No 1000Genomes
ENSVATH05071721 270 Q>K No 1000Genomes
ENSVATH13736001 272 G>D No 1000Genomes
tmp_1_24412382_G_T 276 T>K No 1000Genomes
tmp_1_24412364_T_C 282 Q>R No 1000Genomes
tmp_1_24412362_G_C 283 L>V No 1000Genomes
ENSVATH13735999 288 Q>E No 1000Genomes
tmp_1_24412336_A_T 291 N>K No 1000Genomes
tmp_1_24412320_G_A 297 P>S No 1000Genomes
ENSVATH01473654 300 T>R No 1000Genomes
tmp_1_24412308_C_T 301 G>R No 1000Genomes
ENSVATH14420826 313 A>S No 1000Genomes
ENSVATH05071720 314 Y>S No 1000Genomes
ENSVATH14420825 322 I>F No 1000Genomes
ENSVATH14420825 322 I>V No 1000Genomes
ENSVATH05071718 325 A>P No 1000Genomes
ENSVATH01473652 330 L>P No 1000Genomes
ENSVATH13735998 331 I>T No 1000Genomes
ENSVATH14420804 336 K>I No 1000Genomes
ENSVATH00124477 338 T>A No 1000Genomes
tmp_1_24412108_G_C 338 T>S No 1000Genomes
tmp_1_24412105_A_C 339 F>C No 1000Genomes
tmp_1_24412090_C_T 344 R>Q No 1000Genomes
ENSVATH00124476 354 K>R No 1000Genomes
ENSVATH01473651 363 Q>K No 1000Genomes
tmp_1_24412026_CA_GA,C 365 L>F No 1000Genomes
ENSVATH14420802 365 L>S No 1000Genomes
ENSVATH05071716 371 H>Q No 1000Genomes
tmp_1_24411997_A_G 375 I>T No 1000Genomes
ENSVATH14420800 376 M>I No 1000Genomes
tmp_1_24411987_T_G 378 K>N No 1000Genomes
tmp_1_24411864_G_A 381 P>L No 1000Genomes
tmp_1_24411844_G_C 388 Q>E No 1000Genomes
tmp_1_24411808_C_T 400 G>S No 1000Genomes
tmp_1_24411801_A_G 402 V>A No 1000Genomes
ENSVATH01473646 403 F>C No 1000Genomes
ENSVATH05071708 407 T>I No 1000Genomes
ENSVATH01473645 409 P>S No 1000Genomes
ENSVATH05071707 413 S>R No 1000Genomes
tmp_1_24411757_A_G 417 C>R No 1000Genomes
ENSVATH01473643 423 Y>F No 1000Genomes
ENSVATH01473644 423 Y>N No 1000Genomes
tmp_1_24411727_T_C 427 K>E No 1000Genomes
ENSVATH01473642 429 G>A No 1000Genomes
ENSVATH13735983 431 Q>E No 1000Genomes
ENSVATH05071702 437 D>N No 1000Genomes
ENSVATH14420796 438 I>T No 1000Genomes
ENSVATH13735980 439 N>K No 1000Genomes
ENSVATH14420795 440 A>T No 1000Genomes
tmp_1_24411561_A_G 448 L>S No 1000Genomes
ENSVATH13735976 449 K>N No 1000Genomes
ENSVATH01473623 462 K>N No 1000Genomes
ENSVATH01473622 465 T>S No 1000Genomes
ENSVATH05071693 466 E>Q No 1000Genomes
tmp_1_24411007_C_A 467 L>F No 1000Genomes
ENSVATH13735957 469 E>V No 1000Genomes
ENSVATH01473621 473 T>P No 1000Genomes
tmp_1_24410984_T_C 475 D>G No 1000Genomes
ENSVATH13735955 476 L>V No 1000Genomes
ENSVATH13735951 487 V>I No 1000Genomes
ENSVATH13735950 488 L>V No 1000Genomes
ENSVATH05071692 491 A>E No 1000Genomes
tmp_1_24410937_C_G 491 A>P No 1000Genomes
tmp_1_24410930_G_A 493 A>V No 1000Genomes
tmp_1_24410922_C_A 496 A>S No 1000Genomes
ENSVATH05071691 499 L>* No 1000Genomes
ENSVATH13735949 499 L>M No 1000Genomes
ENSVATH14420770 500 I>V No 1000Genomes
ENSVATH13735948 506 I>M No 1000Genomes
ENSVATH01473619 508 S>L No 1000Genomes
tmp_1_24410882_G_A 509 A>V No 1000Genomes

No associated diseases with Q9SHZ0

1 regional properties for Q9SHZ0

Type Name Position InterPro Accession
domain Protease Do-like, PDZ domain 384 - 509 IPR041517

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mitochondrial membrane Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.

1 GO annotations of molecular function

Name Definition
serine-type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

1 GO annotations of biological process

Name Definition
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9SEL7 DEGP5 Protease Do-like 5, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
Q3E6S8 DEGP14 Putative protease Do-like 14 Arabidopsis thaliana (Mouse-ear cress) PR
O82261 DEGP2 Protease Do-like 2, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MLFRFLQTLA RFCRFLLISV LGFRFSPLLL LGYVKLQDEN KHNSESALAS GTDAKQPEAA
70 80 90 100 110 120
ENVTSSSIDF AVNSVVKVFT VYSMPSVLQP WRNWPQQESG GSGFVISGKK ILTNAHVVAD
130 140 150 160 170 180
HIFLQVRKHG SPTKYKAQVR AIGHECDLAI LEIDNEEFWE DMIPLELGEI PSLDESVAVF
190 200 210 220 230 240
GYPTGGDSVS ITKGYVSRVE YTRYAHGGTT LLAIQTDAAI NPGNSGGPAI IGNKMAGVAF
250 260 270 280 290 300
QKDPSADNIG YIIPTPVIKH FLTAVEENGQ YGGFCTLDIS YQLMENSQLR NHFKMGPEMT
310 320 330 340 350 360
GILINEINPL SDAYKRLRKD DIILAIDDVL IGNDAKVTFR NKERINFNHF VSMKKLDETV
370 380 390 400 410 420
LLQVLRDGKE HEFHIMVKPV PPLVPGHQYD KLPSYYIFAG FVFVPLTQPY IDSTLICNCA
430 440 450 460 470 480
IKYMPEKAGE QLVLADDINA GYTDFKNLKV IKVNGVQVEN LKHLTELVET CWTEDLRLDL
490 500 510
ENEKVVVLNY ANAKEATSLI LELHRIPSAN EYDYQWQS