O82261
Gene name |
DEGP2 (At2g47940, F17A22.33, T9J23.7) |
Protein name |
Protease Do-like 2, chloroplastic |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT2G47940 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for O82261
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 4FLN | X-ray | 280 A | A/B/C | 71-607 | PDB |
| 5ILB | X-ray | 185 A | A/B | 110-315 | PDB |
| AF-O82261-F1 | Predicted | AlphaFoldDB |
20 variants for O82261
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH14625826 | 2 | A>V | No | 1000Genomes | |
| ENSVATH14625825 | 11 | S>P | No | 1000Genomes | |
| ENSVATH13671990 | 17 | V>A | No | 1000Genomes | |
| ENSVATH00801925 | 23 | S>P | No | 1000Genomes | |
| tmp_2_19622089_A_G | 26 | S>P | No | 1000Genomes | |
| ENSVATH13671989 | 44 | I>T | No | 1000Genomes | |
| tmp_2_19621999_G_A | 56 | P>S | No | 1000Genomes | |
| ENSVATH05737181 | 60 | P>T | No | 1000Genomes | |
| tmp_2_19621785_C_T | 99 | S>N | No | 1000Genomes | |
| tmp_2_19621783_G_C | 100 | R>G | No | 1000Genomes | |
| tmp_2_19620989_C_T | 198 | S>N | No | 1000Genomes | |
| tmp_2_19620971_C_T | 204 | G>E | No | 1000Genomes | |
| ENSVATH05737161 | 278 | E>D | No | 1000Genomes | |
| tmp_2_19619665_G_C | 362 | L>V | No | 1000Genomes | |
| ENSVATH05737157 | 369 | V>I | No | 1000Genomes | |
| ENSVATH05737156 | 374 | L>R | No | 1000Genomes | |
| tmp_2_19619311_A_G | 418 | V>A | No | 1000Genomes | |
| ENSVATH05737147 | 463 | T>S | No | 1000Genomes | |
| tmp_2_19618668_A_T | 510 | F>I | No | 1000Genomes | |
| ENSVATH02000248 | 569 | A>T | No | 1000Genomes |
No associated diseases with O82261
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloroplast | A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. |
| chloroplast envelope | The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space. |
| chloroplast stroma | The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis. |
| chloroplast stromal thylakoid | Unstacked thylakoids that connect the grana stacks through the stroma. |
| chloroplast thylakoid membrane | The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| serine-type endopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| chloroplast organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the chloroplast. |
| photosystem II repair | Proteolysis of the damaged D1 protein and re-assembly of a new D1 subunit in the photosystem II following photoinhibition. |
| protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. |
| proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9SEL7 | DEGP5 | Protease Do-like 5, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q3E6S8 | DEGP14 | Putative protease Do-like 14 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SHZ0 | DEGP4 | Protease Do-like 4, mitochondrial | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAASVANCCF | SVLNASVKIQ | SSSISSPWCF | VSASSLTPRA | SSNIKRKSSR | SDSPSPILNP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EKNYPGRVRD | ESSNPPQKMA | FKAFGSPKKE | KKESLSDFSR | DQQTDPAKIH | DASFLNAVVK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VYCTHTAPDY | SLPWQKQRQF | TSTGSAFMIG | DGKLLTNAHC | VEHDTQVKVK | RRGDDRKYVA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KVLVRGVDCD | IALLSVESED | FWKGAEPLRL | GHLPRLQDSV | TVVGYPLGGD | TISVTKGVVS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RIEVTSYAHG | SSDLLGIQID | AAINPGNSGG | PAFNDQGECI | GVAFQVYRSE | ETENIGYVIP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TTVVSHFLTD | YERNGKYTGY | PCLGVLLQKL | ENPALRECLK | VPTNEGVLVR | RVEPTSDASK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VLKEGDVIVS | FDDLHVGCEG | TVPFRSSERI | AFRYLISQKF | AGDIAEIGII | RAGEHKKVQV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VLRPRVHLVP | YHIDGGQPSY | IIVAGLVFTP | LSEPLIEEEC | EDTIGLKLLT | KARYSVARFR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GEQIVILSQV | LANEVNIGYE | DMNNQQVLKF | NGIPIRNIHH | LAHLIDMCKD | KYLVFEFEDN |
| 550 | 560 | 570 | 580 | 590 | 600 |
| YVAVLEREAS | NSASLCILKD | YGIPSERSAD | LLEPYVDPID | DTQALDQGIG | DSPVSNLEIG |
| FDGLVWA |