Q9SG02

PR
Gene name
RDR6 (RDRP6, SDE1, SGS2, At3g49500, T1G12.20, T9C5.95)
Protein name
RNA-dependent RNA polymerase 6
Names
AtRDRP6, Protein SILENCING DEFECTIVE 1, Protein SUPPRESSOR OF GENE SILENCING 2, RNA-directed RNA polymerase 6
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G49500
EC number
2.7.7.48: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1043-1136 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9SG02

Entry ID Method Resolution Chain Position Source
AF-Q9SG02-F1 Predicted AlphaFoldDB

99 variants for Q9SG02

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH06279296 3 S>* No 1000Genomes
ENSVATH02477127 6 N>Y No 1000Genomes
ENSVATH00410959 13 T>S No 1000Genomes
tmp_3_18353115_C_A 31 D>Y No 1000Genomes
ENSVATH12663982 34 E>A No 1000Genomes
tmp_3_18353055_G_A 51 P>S No 1000Genomes
ENSVATH06279292 63 T>P No 1000Genomes
tmp_3_18352934_C_A 91 R>L No 1000Genomes
ENSVATH06279291 92 A>S No 1000Genomes
tmp_3_18352800_T_C 136 T>A No 1000Genomes
tmp_3_18352748_C_T 153 R>K No 1000Genomes
tmp_3_18352658_G_A 183 A>V No 1000Genomes
ENSVATH12663979 184 V>A No 1000Genomes
tmp_3_18352621_C_A 195 L>F No 1000Genomes
ENSVATH12663978 201 D>N No 1000Genomes
tmp_3_18352557_T_A 217 I>F No 1000Genomes
tmp_3_18352430_A_G 259 V>A No 1000Genomes
tmp_3_18352422_T_C 262 I>V No 1000Genomes
ENSVATH06279287 266 H>P No 1000Genomes
ENSVATH12663976 271 L>F No 1000Genomes
ENSVATH12663975 288 R>S No 1000Genomes
tmp_3_18352337_C_T 290 R>Q No 1000Genomes
tmp_3_18352329_G_T 293 Q>K No 1000Genomes
tmp_3_18352321_T_A 295 E>D No 1000Genomes
tmp_3_18352319_C_T 296 R>H No 1000Genomes
tmp_3_18352296_G_A 304 R>C No 1000Genomes
tmp_3_18352272_G_A 312 P>S No 1000Genomes
tmp_3_18352269_C_T 313 V>M No 1000Genomes
tmp_3_18352266_A_T 314 S>T No 1000Genomes
ENSVATH12663954 350 E>K No 1000Genomes
ENSVATH06279284 360 P>L No 1000Genomes
tmp_3_18352128_G_A 360 P>S No 1000Genomes
ENSVATH02477117 364 N>S No 1000Genomes
tmp_3_18352112_A_G 365 I>T No 1000Genomes
ENSVATH00410956 382 Y>F No 1000Genomes
ENSVATH06279283 390 E>K No 1000Genomes
ENSVATH06279282 396 P>S No 1000Genomes
ENSVATH02477115 404 Q>K No 1000Genomes
tmp_3_18351957_T_C 417 T>A No 1000Genomes
tmp_3_18351827_G_A 460 S>L No 1000Genomes
ENSVATH06279281 473 D>N No 1000Genomes
tmp_3_18351714_T_G 498 K>Q No 1000Genomes
tmp_3_18351707_C_G 500 C>S No 1000Genomes
tmp_3_18351625_T_A 527 K>N No 1000Genomes
tmp_3_18351624_T_C 528 T>A No 1000Genomes
tmp_3_18351610_A_C 532 D>E No 1000Genomes
ENSVATH12663953 571 D>G No 1000Genomes
ENSVATH06279280 571 D>N No 1000Genomes
tmp_3_18351428_G_A 593 P>L No 1000Genomes
ENSVATH12663952 596 A>T No 1000Genomes
tmp_3_18351415_G_T 597 D>E No 1000Genomes
ENSVATH12663951 618 Y>F No 1000Genomes
ENSVATH09440761 627 R>C No 1000Genomes
tmp_3_18351299_C_T 636 R>K No 1000Genomes
tmp_3_18351269_A_T 646 F>Y No 1000Genomes
ENSVATH00410954 650 H>Y No 1000Genomes
ENSVATH14408158 666 L>S No 1000Genomes
ENSVATH06279279 676 V>I No 1000Genomes
ENSVATH12663949 684 F>C No 1000Genomes
ENSVATH06279277 697 R>H No 1000Genomes
tmp_3_18351108_C_T 700 D>N No 1000Genomes
tmp_3_18351101_G_A 702 T>I No 1000Genomes
ENSVATH12663948 703 D>Y No 1000Genomes
tmp_3_18351092_G_T 705 A>E No 1000Genomes
ENSVATH06279275 710 T>M No 1000Genomes
ENSVATH06279274 711 A>V No 1000Genomes
tmp_3_18351066_C_G 714 A>P No 1000Genomes
ENSVATH00410953 739 M>I No 1000Genomes
ENSVATH14408156 759 V>I No 1000Genomes
tmp_3_18350843_G_A 788 S>F No 1000Genomes
tmp_3_18350774_T_A 811 K>I No 1000Genomes
tmp_3_18350768_T_G 813 Y>S No 1000Genomes
ENSVATH12663946 839 H>L No 1000Genomes
tmp_3_18350670_T_C 846 I>V No 1000Genomes
ENSVATH12663945 850 K>E No 1000Genomes
tmp_3_18350586_C_G 874 D>H No 1000Genomes
tmp_3_18350035_T_C 917 N>D No 1000Genomes
tmp_3_18349893_G_A 964 S>L No 1000Genomes
tmp_3_18349830_G_A 985 T>I No 1000Genomes
ENSVATH00410952 994 R>Q No 1000Genomes
ENSVATH14408144 994 R>W No 1000Genomes
ENSVATH12663912 997 R>I No 1000Genomes
ENSVATH02477100 998 R>Q No 1000Genomes
ENSVATH14408143 1014 S>R No 1000Genomes
ENSVATH12663911 1017 P>T No 1000Genomes
ENSVATH14408142 1018 S>R No 1000Genomes
tmp_3_18349722_G_A 1021 P>L No 1000Genomes
ENSVATH00410951 1030 G>R No 1000Genomes
ENSVATH00410950 1044 L>S No 1000Genomes
tmp_3_18349548_T_C 1079 K>R No 1000Genomes
tmp_3_18349484_T_G 1100 K>N No 1000Genomes
ENSVATH14408140 1104 E>A No 1000Genomes
ENSVATH00410948 1112 L>F No 1000Genomes
tmp_3_18349432_T_C 1118 N>D No 1000Genomes
tmp_3_18349382_A_T 1134 H>Q No 1000Genomes
tmp_3_18349377_T_C 1136 E>G No 1000Genomes
ENSVATH00410947 1136 E>K No 1000Genomes
ENSVATH06279259 1147 P>L No 1000Genomes
ENSVATH06279256 1169 I>V No 1000Genomes

No associated diseases with Q9SG02

No regional properties for Q9SG02

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9SG02

Functions

Description
EC Number 2.7.7.48 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasmic granule
  • Nucleus
  • Colocalize with SGS3 in cytoplasmic granules distinct from P-bodies
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nuclear RNA-directed RNA polymerase complex A complex required for RNAi mediated heterochromatin assembly. In S. pombe this contains RNA-directed RNA polymerase, a putative helicase and a protein containing a pap25 associated domain.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.

10 GO annotations of biological process

Name Definition
defense response to virus Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
gene silencing by RNA A process in which an RNA molecule reduces expression of target genes. This can occur pre-transcriptionally by assembly of heterochromatin and prevention of transcription or co- or post-transcriptionally by targeting RNAs for degradation or by interfering with splicing or translation. This process starts once the inhibitory RNA molecule has been transcribed, and includes processing of the RNA such as cleavage, modifications, transport from the nucleus to the cytoplasm, loading onto the RISC complex, and the effect on transcription or translation.
gynoecium development The process whose specific outcome is the progression of the gynoecium over time, from its formation to the mature structure. The gynoecium is the collective name for the carpels of a flower.
leaf development The process whose specific outcome is the progression of the leaf over time, from its formation to the mature structure.
maintenance of shoot apical meristem identity The process in which an organism retains a population of shoot apical meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate.
post-transcriptional gene silencing by RNA A posttranscriptional gene silencing pathway in which regulatory RNAs elicit silencing of specific target genes, either by mRNA destabilization or inhibition of translation.
recognition of pollen A cell recognition process in which pollen is recognized and either accepted or rejected by cells in the stigma.
RNAi-mediated antiviral immune response A post-transcriptional gene silencing pathway mediated by the action of regulatory RNAs that protects against foreign organism invasion by restricting viral replication and dissemination.
siRNA processing A process leading to the generation of a functional small interfering RNA (siRNA). Includes the cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides. May also include amplification of the siRNA by RNA-directed RNA polymerase.
ta-siRNA processing A process leading to the generation of a functional trans-acting small interfering RNA (ta-siRNA). ta-siRNAs function like miRNAs to guide cleavage of target mRNAs.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O82188 RDR5 Probable RNA-dependent RNA polymerase 5 Arabidopsis thaliana (Mouse-ear cress) PR
O82189 RDR4 Probable RNA-dependent RNA polymerase 4 Arabidopsis thaliana (Mouse-ear cress) PR
O82190 RDR3 Probable RNA-dependent RNA polymerase 3 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MGSEGNMKKS VVTQVSIGGF GESTTAKQLT DYLEDEVGIV WRCRLKTSWT PPGSYPNFEI
70 80 90 100 110 120
ADTSNIPSID EYKKVEPHAF VHFAVFESAG RAMDAAGQCN LILDGQPLKV SLGPKNPYSL
130 140 150 160 170 180
NQRRRTTVPY KLAGITLEIG TLVSRDDFFV SWRAEGVDFL VDPFDNTCKF CFRKSTAFSF
190 200 210 220 230 240
KDAVMHAVIN CDYKLELLVR DIQTVRQYKT LHGFVLILQL ASSPRVWYRT ADDDIYDTVP
250 260 270 280 290 300
GDLLDDDDPW IRTTDFTQVG AIGRCHSYRV LISPRYENKL RTALDYFRMR RVQEERVRWP
310 320 330 340 350 360
PRIRNEPCFG EPVSDHFFCI HHKEGISFEI MFLVNSVLHR GVFNQFQLTE RFFDLLRNQP
370 380 390 400 410 420
KDVNIASLKH LCTYKRPVFD AYKRLKLVQE WIQKNPKLLG SHEQSEDISE IRRLVITPTR
430 440 450 460 470 480
AYCLPPEVEL SNRVLRRYKA VAERFLRVTF MDESMQTINS NVLSYFVAPI VKDLTSSSFS
490 500 510 520 530 540
QKTYVFKRVK SILTDGFKLC GRKYSFLAFS ANQLRDRSAW FFAEDGKTRV SDIKTWMGKF
550 560 570 580 590 600
KDKNVAKCAA RMGLCFSSTY ATVDVMPHEV DTEVPDIERN GYVFSDGIGT ITPDLADEVM
610 620 630 640 650 660
EKLKLDVHYS PCAYQIRYAG FKGVVARWPS KSDGIRLALR DSMKKFFSKH TILEICSWTR
670 680 690 700 710 720
FQPGFLNRQI ITLLSVLGVP DEIFWDMQES MLYKLNRILD DTDVAFEVLT ASCAEQGNTA
730 740 750 760 770 780
AIMLSAGFKP KTEPHLRGML SSVRIAQLWG LREKSRIFVT SGRWLMGCLD EAGILEHGQC
790 800 810 820 830 840
FIQVSKPSIE NCFSKHGSRF KETKTDLEVV KGYVAIAKNP CLHPGDVRIL EAVDVPQLHH
850 860 870 880 890 900
MYDCLIFPQK GDRPHTNEAS GSDLDGDLYF VAWDQKLIPP NRKSYPAMHY DAAEEKSLGR
910 920 930 940 950 960
AVNHQDIIDF FARNLANEQL GTICNAHVVH ADRSEYGAMD EECLLLAELA ATAVDFPKTG
970 980 990 1000 1010 1020
KIVSMPFHLK PKLYPDFMGK EDYQTYKSNK ILGRLYRRVK EVYDEDAEAS SEESTDPSAI
1030 1040 1050 1060 1070 1080
PYDAVLEIPG FEDLIPEAWG HKCLYDGQLI GLLGQYKVQK EEEIVTGHIW SMPKYTSKKQ
1090 1100 1110 1120 1130 1140
GELKERLKHS YNSLKKEFRK VFEETIPDHE NLSEEEKNIL YEKKASAWYH VTYHPEWVKK
1150 1160 1170 1180 1190
SLELQDPDES SHAAMLSFAW IAADYLARIK IRSREMGSID SAKPVDSLAK FLAQRL