O82188

PR
Gene name
RDR5 (RDRP5, At2g19930, F6F22.4)
Protein name
Probable RNA-dependent RNA polymerase 5
Names
AtRDRP5, RNA-directed RNA polymerase 5
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT2G19930
EC number
2.7.7.48: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

2-152 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O82188

Entry ID Method Resolution Chain Position Source
AF-O82188-F1 Predicted AlphaFoldDB

99 variants for O82188

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH14522917 15 R>L No 1000Genomes
ENSVATH05538229 19 A>T No 1000Genomes
ENSVATH00239629 54 K>N No 1000Genomes
ENSVATH01848769 55 V>A No 1000Genomes
ENSVATH00239628 59 Q>R No 1000Genomes
tmp_2_8612260_C_T 61 G>D No 1000Genomes
ENSVATH05538227 71 V>L No 1000Genomes
ENSVATH13291195 76 Q>E No 1000Genomes
ENSVATH00239626 85 Q>R No 1000Genomes
ENSVATH05538224 90 L>F No 1000Genomes
tmp_2_8612164_G_A 93 S>F No 1000Genomes
ENSVATH05538221 103 E>G No 1000Genomes
ENSVATH05538220 107 V>F No 1000Genomes
ENSVATH00239624 154 V>L No 1000Genomes
tmp_2_8611734_C_T 160 A>T No 1000Genomes
ENSVATH05538217 164 R>K No 1000Genomes
tmp_2_8611711_T_G 167 K>N No 1000Genomes
ENSVATH13291160 169 L>F No 1000Genomes
ENSVATH05538216 179 W>C No 1000Genomes
ENSVATH00239623 182 L>F No 1000Genomes
tmp_2_8611658_T_C 185 H>R No 1000Genomes
ENSVATH01848748 196 Q>L No 1000Genomes
ENSVATH01848747 208 N>H No 1000Genomes
tmp_2_8611205_C_T 232 G>E No 1000Genomes
ENSVATH01848735 242 D>E No 1000Genomes
ENSVATH13291134 254 K>E No 1000Genomes
ENSVATH01848733 261 I>N No 1000Genomes
ENSVATH01848732 263 H>R No 1000Genomes
tmp_2_8611113_G_A 263 H>Y No 1000Genomes
tmp_2_8611058_C_T 281 R>H No 1000Genomes
ENSVATH13291131 285 F>C No 1000Genomes
tmp_2_8610882_A_G 287 F>L No 1000Genomes
tmp_2_8610826_T_G 305 K>N No 1000Genomes
tmp_2_8610812_C_T 310 R>H No 1000Genomes
tmp_2_8610807_C_T 312 D>N No 1000Genomes
ENSVATH00239620 316 F>S No 1000Genomes
tmp_2_8610791_T_G 317 Y>S No 1000Genomes
ENSVATH01848723 325 L>F No 1000Genomes
ENSVATH05538204 333 A>V No 1000Genomes
ENSVATH01848722 335 M>T No 1000Genomes
tmp_2_8610720_G_T 341 H>N No 1000Genomes
ENSVATH13291128 353 F>L No 1000Genomes
tmp_2_8610496_G_A 381 H>Y No 1000Genomes
ENSVATH00239617 412 M>L No 1000Genomes
tmp_2_8610281_A_C 418 F>V No 1000Genomes
ENSVATH05538193 432 C>F No 1000Genomes
ENSVATH13291091 433 Y>N No 1000Genomes
tmp_2_8610010_A_T 439 L>M No 1000Genomes
ENSVATH13291090 464 R>L No 1000Genomes
tmp_2_8609835_C_G 467 Q>H No 1000Genomes
ENSVATH01848703 467 Q>K No 1000Genomes
ENSVATH01848702 469 R>* No 1000Genomes
tmp_2_8609828_G_A 470 P>S No 1000Genomes
tmp_2_8609801_G_A 479 P>S No 1000Genomes
ENSVATH05538188 487 F>C No 1000Genomes
tmp_2_8609624_T_C 501 R>G No 1000Genomes
ENSVATH05538186 539 N>K No 1000Genomes
ENSVATH05538185 540 K>I No 1000Genomes
ENSVATH05538185 540 K>T No 1000Genomes
ENSVATH01848692 548 L>H No 1000Genomes
ENSVATH01848691 549 N>T No 1000Genomes
tmp_2_8609322_G_T 571 P>T No 1000Genomes
ENSVATH05538183 572 H>Y No 1000Genomes
ENSVATH01848686 585 K>Q No 1000Genomes
ENSVATH01848685 601 L>I No 1000Genomes
ENSVATH01848683 610 A>E No 1000Genomes
ENSVATH01848682 617 C>F No 1000Genomes
ENSVATH13291080 639 F>S No 1000Genomes
ENSVATH13291079 646 K>R No 1000Genomes
ENSVATH13291079 646 K>T No 1000Genomes
ENSVATH05538180 695 E>Q No 1000Genomes
ENSVATH13291077 703 S>G No 1000Genomes
tmp_2_8608635_T_G 730 E>D No 1000Genomes
tmp_2_8608628_G_A 733 L>F No 1000Genomes
ENSVATH05538176 774 A>P No 1000Genomes
tmp_2_8608403_T_G 779 K>Q No 1000Genomes
tmp_2_8608340_C_T 800 V>I No 1000Genomes
ENSVATH01848664 802 L>F No 1000Genomes
ENSVATH05538175 817 R>Q No 1000Genomes
ENSVATH01848662 818 D>E No 1000Genomes
tmp_2_8608248_G_C 830 I>M No 1000Genomes
ENSVATH01848661 831 F>Y No 1000Genomes
ENSVATH05538174 844 P>L No 1000Genomes
ENSVATH00239614 852 P>R No 1000Genomes
tmp_2_8608061_C_A 861 E>* No 1000Genomes
ENSVATH13291050 861 E>D No 1000Genomes
ENSVATH00239613 869 L>V No 1000Genomes
ENSVATH13291049 870 W>* No 1000Genomes
tmp_2_8608007_T_C 879 T>A No 1000Genomes
ENSVATH00239612 882 M>I No 1000Genomes
tmp_2_8607950_T_C 898 K>E No 1000Genomes
ENSVATH05538167 908 E>K No 1000Genomes
tmp_2_8607741_T_G 909 D>A No 1000Genomes
ENSVATH01848652 920 Q>L No 1000Genomes
tmp_2_8607665_A_T 934 H>Q No 1000Genomes
ENSVATH01848650 941 R>G No 1000Genomes
tmp_2_8607578_T_A 963 K>N No 1000Genomes
ENSVATH00239607 964 C>S No 1000Genomes
tmp_2_8607537_C_G 977 G>A No 1000Genomes

No associated diseases with O82188

No regional properties for O82188

Type Name Position InterPro Accession
No domain, repeats, and functional sites for O82188

Functions

Description
EC Number 2.7.7.48 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nuclear RNA-directed RNA polymerase complex A complex required for RNAi mediated heterochromatin assembly. In S. pombe this contains RNA-directed RNA polymerase, a putative helicase and a protein containing a pap25 associated domain.

2 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.
RNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.

1 GO annotations of biological process

Name Definition
siRNA processing A process leading to the generation of a functional small interfering RNA (siRNA). Includes the cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides. May also include amplification of the siRNA by RNA-directed RNA polymerase.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O82189 RDR4 Probable RNA-dependent RNA polymerase 4 Arabidopsis thaliana (Mouse-ear cress) PR
O82190 RDR3 Probable RNA-dependent RNA polymerase 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SG02 RDR6 RNA-dependent RNA polymerase 6 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MNQASSRIRI ALSGRIETAL ENIYRKHNLT PINDETRQRL SSIPENLGFE LVRKVFSLQA
70 80 90 100 110 120
GLIYNLDSFI VSKVNQAVSF TGYPQPANSL SPSGRHVSRV LQEEMSVDSD APSPKSLKSE
130 140 150 160 170 180
DKGGSLHIPQ LVALGELEFK KVFLLLSYIP GQHVGQVITA DEIRLWKDLP MVEYEAAVWD
190 200 210 220 230 240
RLGRHYCPQK DRRMLQWDSG KTHYYQCNVA PNGSYTFKVL SALQGPLLEH TGTHLHKVLG
250 260 270 280 290 300
DDNVLTVKFA DVQKSSSTYS IDHYFTYKGI AKNGIMIGLR RYQFFVFKDG GKEEKKKDLS
310 320 330 340 350 360
TKKVKCYFIR TDSTAFYDMQ NPYILTGKSI YEARMHFMHV HRAPTLANYM ARFSLILSKT
370 380 390 400 410 420
KTLEVDMTGI TFDQIDDIHC HDQDGKDVLD KNKKPCIHSD GTGYISEDLA RMCPLNIFKG
430 440 450 460 470 480
KCLRSESIQE ACYQDPPLLI QFRMFYDGYA VKGTFLLNKK LCPRTVQVRP SMIKVSKDPS
490 500 510 520 530 540
LSNFSTFNAL EVVTTSNPPK RTKLSKNLVA LLSYGGIPNE FFLDILLNTL EESKSIFYNK
550 560 570 580 590 600
RAALNAALNY GEMDDQNAAQ MILVGIPLDE PHLKNYLSIL LKTEKNDLKA GKLPVTESYY
610 620 630 640 650 660
LMGTVDPTGA LKEDEVCVIL ESGQISGEVL VYRNPGLHFG DIHILKATYV KALEEYVGNS
670 680 690 700 710 720
KFAVFFPQKG PRSLGDEIAG GDFDGDMYFI SRNPELLENF KPSEPWVSLT PPSKSNSGRA
730 740 750 760 770 780
PSQLSPEELE EELFEMFLTA GFHASNVIGI AADSWLTIMD RFLILGDDRA EEKAEMKKKM
790 800 810 820 830 840
LELIDIYYDA LDAPKKGDKV YLPNKLKPDI FPHYMERDKK FQSTSILGLI FDFVKSQTTE
850 860 870 880 890 900
EPSPSSEISK LPCFEDEPVS EFHMQKCRLW YDNYRTEMTQ AMKTDKDESA NEVIQRYKQE
910 920 930 940 950 960
FYGAAGFEDS KKSLEELYPQ ALALYKIVYD YAIHAGVSKC RFVWKVAGPV LCRFYLNKKM
970
QEKCLVCAPS VLKELWG