Q9SAR0

PR
Gene name
ACS6 (ACC6, At4g11280, F8L21.70)
Protein name
1-aminocyclopropane-1-carboxylate synthase 6
Names
ACC synthase 6, S-adenosyl-L-methionine methylthioadenosine-lyase 6
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT4G11280
EC number
4.4.1.14: Carbon-sulfur lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-61 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9SAR0

Entry ID Method Resolution Chain Position Source
AF-Q9SAR0-F1 Predicted AlphaFoldDB

36 variants for Q9SAR0

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH06615738 6 T>S No 1000Genomes
ENSVATH14134241 13 N>T No 1000Genomes
tmp_4_6864260_C_G 31 F>L No 1000Genomes
tmp_4_6864284_A_C 39 E>D No 1000Genomes
ENSVATH14134243 67 R>C No 1000Genomes
tmp_4_6864530_A_G 92 I>V No 1000Genomes
tmp_4_6864664_C_G 105 A>G No 1000Genomes
ENSVATH14134244 115 N>I No 1000Genomes
ENSVATH14134244 115 N>S No 1000Genomes
tmp_4_6864807_A_T 153 T>S No 1000Genomes
tmp_4_6865087_C_G 218 T>R No 1000Genomes
tmp_4_6865102_G_A 223 C>Y No 1000Genomes
ENSVATH06615751 262 E>D No 1000Genomes
ENSVATH06615752 264 I>N No 1000Genomes
ENSVATH06615753 266 D>N No 1000Genomes
ENSVATH11496654 293 Y>C No 1000Genomes
tmp_4_6865411_A_G 326 D>G No 1000Genomes
tmp_4_6865432_T_A 333 F>Y No 1000Genomes
ENSVATH00490037 334 I>T No 1000Genomes
ENSVATH11496685 336 E>A No 1000Genomes
ENSVATH11496686 382 D>E No 1000Genomes
tmp_4_6865587_A_T 385 T>S No 1000Genomes
ENSVATH14134266 394 Q>L No 1000Genomes
tmp_4_6865663_C_T 410 P>L No 1000Genomes
ENSVATH02786138 422 H>Q No 1000Genomes
ENSVATH06615758 427 T>I No 1000Genomes
ENSVATH11496687 433 R>K No 1000Genomes
ENSVATH06615759 442 E>K No 1000Genomes
tmp_4_6865761_A_G 443 T>A No 1000Genomes
ENSVATH11496688 444 K>I No 1000Genomes
ENSVATH11496689 453 A>T No 1000Genomes
ENSVATH14134267 455 K>Q No 1000Genomes
ENSVATH06615760 456 K>T No 1000Genomes
ENSVATH06615761 469 S>T No 1000Genomes
ENSVATH14134268 478 F>Y No 1000Genomes
tmp_4_6865876_C_T 481 P>L No 1000Genomes

No associated diseases with Q9SAR0

2 regional properties for Q9SAR0

Type Name Position InterPro Accession
binding_site Aminotransferases, class-I, pyridoxal-phosphate-binding site 277 - 290 IPR004838
domain Aminotransferase, class I/classII 52 - 432 IPR004839

Functions

Description
EC Number 4.4.1.14 Carbon-sulfur lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
1-aminocyclopropane-1-carboxylate synthase activity Catalysis of the reaction: S-adenosyl-L-methionine(1+) = 1-aminocyclopropane-1-carboxylate + S-methyl-5'-thioadenosine + H(+).
identical protein binding Binding to an identical protein or proteins.
pyridoxal phosphate binding Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
transaminase activity Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid.

11 GO annotations of biological process

Name Definition
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells.
defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
ethylene biosynthetic process The chemical reactions and pathways resulting in the formation of ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator.
fruit ripening An developmental maturation process that has as participant a fruit. Ripening causes changes in one or more characteristics of a fruit (color, aroma, flavor, texture, hardness, cell wall structure) and may make it more attractive to animals and aid in seed dispersal.
phloem or xylem histogenesis The process whose specific outcome is the progression of phloem and/or xylem over time, from formation to the mature structure. An example of this process is found in Arabidopsis thaliana.
response to auxin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus.
response to jasmonic acid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus.
response to mechanical stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
response to oxidative stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
response to wounding Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P31531 ACS1 1-aminocyclopropane-1-carboxylate synthase Glycine max (Soybean) (Glycine hispida) PR
Q9STR4 ACS7 1-aminocyclopropane-1-carboxylate synthase 7 Arabidopsis thaliana (Mouse-ear cress) PR
Q06402 ACS2 1-aminocyclopropane-1-carboxylate synthase 2 Arabidopsis thaliana (Mouse-ear cress) PR
P18485 ACS2 1-aminocyclopropane-1-carboxylate synthase 2 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
10 20 30 40 50 60
MVAFATEKKQ DLNLLSKIAS GDGHGENSSY FDGWKAYEEN PFHPIDRPDG VIQMGLAENQ
70 80 90 100 110 120
LCGDLMRKWV LKHPEASICT SEGVNQFSDI AIFQDYHGLP EFRQAVAKFM EKTRNNKVKF
130 140 150 160 170 180
DPDRIVMSGG ATGAHETVAF CLANPGDGFL VPTPYYPGFD RDLRWRTGVN LVPVTCHSSN
190 200 210 220 230 240
GFKITVEALE AAYENARKSN IPVKGLLVTN PSNPLGTTLD RECLKSLVNF TNDKGIHLIA
250 260 270 280 290 300
DEIYAATTFG QSEFISVAEV IEEIEDCNRD LIHIVYSLSK DMGLPGLRVG IVYSYNDRVV
310 320 330 340 350 360
QIARKMSSFG LVSSQTQHLI AKMLSDEEFV DEFIRESKLR LAARHAEITT GLDGLGIGWL
370 380 390 400 410 420
KAKAGLFLWM DLRNLLKTAT FDSETELWRV IVHQVKLNVS PGGSFHCHEP GWFRVCFANM
430 440 450 460 470 480
DHKTMETALE RIRVFTSQLE EETKPMAATT MMAKKKKKCW QSNLRLSFSD TRRFDDGFFS
490
PHSPVPPSPL VRAQT