Q06402
Gene name |
ACS2 (ACC1, At1g01480, F22L4.4) |
Protein name |
1-aminocyclopropane-1-carboxylate synthase 2 |
Names |
ACC synthase 2, S-adenosyl-L-methionine methylthioadenosine-lyase 2 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G01480 |
EC number |
4.4.1.14: Carbon-sulfur lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q06402
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q06402-F1 | Predicted | AlphaFoldDB |
47 variants for Q06402
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH04502567 | 6 | K>* | No | 1000Genomes | |
| ENSVATH04502568 | 6 | K>T | No | 1000Genomes | |
| ENSVATH01001819 | 7 | N>S | No | 1000Genomes | |
| ENSVATH00000774 | 11 | V>D | No | 1000Genomes | |
| tmp_1_175906_A_G | 15 | I>M | No | 1000Genomes | |
| tmp_1_175907_G_A | 16 | A>T | No | 1000Genomes | |
| ENSVATH10441842 | 26 | E>Q | No | 1000Genomes | |
| tmp_1_175997_C_T | 46 | H>Y | No | 1000Genomes | |
| ENSVATH01001823 | 57 | Q>L | No | 1000Genomes | |
| tmp_1_176238_A_G | 68 | K>R | No | 1000Genomes | |
| ENSVATH04502572 | 73 | A>V | No | 1000Genomes | |
| ENSVATH00000775 | 81 | I>V | No | 1000Genomes | |
| ENSVATH01001837 | 112 | G>R | No | 1000Genomes | |
| ENSVATH00000780 | 123 | V>A | No | 1000Genomes | |
| ENSVATH10441911 | 123 | V>I | No | 1000Genomes | |
| 136 | M>I | No | |||
| tmp_1_177050_A_G | 164 | T>A | No | 1000Genomes | |
| tmp_1_177068_C_A | 170 | P>T | No | 1000Genomes | |
| ENSVATH04502595 | 177 | D>G | No | 1000Genomes | |
| ENSVATH01001840 | 177 | D>N | No | 1000Genomes | |
| tmp_1_177107_G_A | 183 | V>I | No | 1000Genomes | |
| ENSVATH00000783 | 184 | D>E | No | 1000Genomes | |
| tmp_1_177117_C_T | 186 | A>V | No | 1000Genomes | |
| ENSVATH01001842 | 187 | E>D | No | 1000Genomes | |
| ENSVATH10441941 | 229 | T>R | No | 1000Genomes | |
| ENSVATH10441942 | 247 | A>V | No | 1000Genomes | |
| ENSVATH04502598 | 255 | A>T | No | 1000Genomes | |
| ENSVATH13848254 | 261 | V>A | No | 1000Genomes | |
| ENSVATH01001845 | 263 | I>T | No | 1000Genomes | |
| ENSVATH04502599 | 265 | E>K | No | 1000Genomes | |
| tmp_1_177361_C_A | 267 | N>K | No | 1000Genomes | |
| tmp_1_177450_C_T | 297 | S>L | No | 1000Genomes | |
| ENSVATH04502601 | 299 | V>M | No | 1000Genomes | |
| tmp_1_177486_G_A | 309 | G>E | No | 1000Genomes | |
| tmp_1_177514_G_A | 318 | M>I | No | 1000Genomes | |
| tmp_1_177533_G_A | 325 | D>N | No | 1000Genomes | |
| tmp_1_177537_A_G | 326 | D>G | No | 1000Genomes | |
| tmp_1_177585_T_C | 342 | I>T | No | 1000Genomes | |
| ENSVATH01001846 | 345 | K>E | No | 1000Genomes | |
| tmp_1_177599_T_C | 347 | F>L | No | 1000Genomes | |
| ENSVATH00000793 | 351 | I>L | No | 1000Genomes | |
| ENSVATH00000794 | 394 | R>K | No | 1000Genomes | |
| tmp_1_177809_T_A | 417 | F>I | No | 1000Genomes | |
| tmp_1_177821_G_A | 421 | D>N | No | 1000Genomes | |
| ENSVATH04502603 | 441 | N>Y | No | 1000Genomes | |
| tmp_1_177893_G_A | 445 | E>K | No | 1000Genomes | |
| ENSVATH00000795 | 450 | N>I | No | 1000Genomes |
No associated diseases with Q06402
Functions
| Description | ||
|---|---|---|
| EC Number | 4.4.1.14 | Carbon-sulfur lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| 1-aminocyclopropane-1-carboxylate synthase activity | Catalysis of the reaction: S-adenosyl-L-methionine(1+) = 1-aminocyclopropane-1-carboxylate + S-methyl-5'-thioadenosine + H(+). |
| pyridoxal phosphate binding | Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. |
| transaminase activity | Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular amino acid metabolic process | The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells. |
| ethylene biosynthetic process | The chemical reactions and pathways resulting in the formation of ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator. |
| fruit ripening | An developmental maturation process that has as participant a fruit. Ripening causes changes in one or more characteristics of a fruit (color, aroma, flavor, texture, hardness, cell wall structure) and may make it more attractive to animals and aid in seed dispersal. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P31531 | ACS1 | 1-aminocyclopropane-1-carboxylate synthase | Glycine max (Soybean) (Glycine hispida) | PR |
| Q9SAR0 | ACS6 | 1-aminocyclopropane-1-carboxylate synthase 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9STR4 | ACS7 | 1-aminocyclopropane-1-carboxylate synthase 7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P18485 | ACS2 | 1-aminocyclopropane-1-carboxylate synthase 2 | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGLPGKNKGA | VLSKIATNNQ | HGENSEYFDG | WKAYDKDPFH | LSRNPHGIIQ | MGLAENQLCL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DLIKDWVKEN | PEASICTLEG | IHQFSDIANF | QDYHGLKKFR | QAIAHFMGKA | RGGRVTFDPE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RVVMSGGATG | ANETIMFCLA | DPGDVFLIPS | PYYAAFDRDL | RWRTGVEIIP | VPCSSSDNFK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LTVDAAEWAY | KKAQESNKKV | KGLILTNPSN | PLGTMLDKDT | LTNLVRFVTR | KNIHLVVDEI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YAATVFAGGD | FVSVAEVVND | VDISEVNVDL | IHIVYSLSKD | MGLPGFRVGI | VYSFNDSVVS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| CARKMSSFGL | VSSQTQLMLA | SMLSDDQFVD | NFLMESSRRL | GIRHKVFTTG | IKKADIACLT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SNAGLFAWMD | LRHLLRDRNS | FESEIELWHI | IIDRVKLNVS | PGSSFRCTEP | GWFRICFANM |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DDDTLHVALG | RIQDFVSKNK | NKIVEKASEN | DQVIQNKSAK | KLKWTQTNLR | LSFRRLYEDG |
| 490 | |||||
| LSSPGIMSPH | SPLLRA |