AiPD: Autoinhibited Protein Database

Gene name	ACS2 (ACC2, PCVV4A)
Protein name	1-aminocyclopropane-1-carboxylate synthase 2
Names	ACC synthase 2, Le-ACS2, ACS-2, S-adenosyl-L-methionine methylthioadenosine-lyase 2
Species	Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
KEGG Pathway	sly:606304
EC number	4.4.1.14: Carbon-sulfur lyases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-52 (Predicted disordered autoinhibitory region) PR

1-52 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
1IAX	X-ray	280 A	A/B	11-438	PDB
1IAY	X-ray	270 A	A	11-438	PDB
AF-P18485-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
vcZ113YTL	6	A>T	No	Ensembl
vcZ113YTJ	8	T>N	No	Ensembl
vcZ113YTF	22	G>S	No	Ensembl
vcZ113YSQ	60	L>F	No	Ensembl
vcZ113YSO	72	K>I	No	Ensembl
vcZ113YSL	100	K>R	No	Ensembl
vcZ113YSA	115	R>S	No	Ensembl
vcZ113YP0	166	Q>K	No	Ensembl
vcZ113YOY	176	N>D	No	Ensembl
vcZ113YOX	186	K>T	No	Ensembl
vcZ113YOU	192	A>T	No	Ensembl
vcZ113YOT	194	K>E	No	Ensembl
vcZ113YOS	196	N>K	No	Ensembl
vcZ113YOR	200	K>R	No	Ensembl
vcZ113YOO	223	V>L	No	Ensembl
vcZ113YON	248	P>L	No	Ensembl
vcZ113YOL	253	I>V	No	Ensembl
vcZ113YOJ	259	E>A	No	Ensembl
vcZ113YOI	260	Q>K	No	Ensembl
vcZ113YOB	290	I>V	No	Ensembl
vcZ113YO9	295	D>N	No	Ensembl
vcZ113YO0	336	A>S	No	Ensembl
vcZ113YNZ	340	G>A	No	Ensembl
vcZ113YNY	344	K>E	No	Ensembl
vcZ113YNW	352	V>E	No	Ensembl
vcZ113YNS	381	S>C	No	Ensembl
vcZ113YNR	381	S>N	No	Ensembl
vcZ113YNI	421	G>E	No	Ensembl
vcZ113YNB	445	S>A	No	Ensembl
vcZ113YNB	445	S>T	No	Ensembl
vcZ113YN7	467	D>E	No	Ensembl
vcZ113YN6	469	S>N	No	Ensembl

Type	Name	Position	InterPro Accession
conserved_site	Aminoacyl-tRNA synthetase, class I, conserved site	39 - 49	IPR001412
domain	RNA-binding S4 domain	353 - 414	IPR002942

		Description
EC Number	4.4.1.14	Carbon-sulfur lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
No GO annotations for cellular component

Name	Definition
1-aminocyclopropane-1-carboxylate synthase activity	Catalysis of the reaction: S-adenosyl-L-methionine(1+) = 1-aminocyclopropane-1-carboxylate + S-methyl-5'-thioadenosine + H(+).
pyridoxal phosphate binding	Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
transaminase activity	Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid.

Name	Definition
cellular amino acid metabolic process	The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells.
ethylene biosynthetic process	The chemical reactions and pathways resulting in the formation of ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator.
fruit ripening	An developmental maturation process that has as participant a fruit. Ripening causes changes in one or more characteristics of a fruit (color, aroma, flavor, texture, hardness, cell wall structure) and may make it more attractive to animals and aid in seed dispersal.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P31531	ACS1	1-aminocyclopropane-1-carboxylate synthase	Glycine max (Soybean) (Glycine hispida)	PR
Q9SAR0	ACS6	1-aminocyclopropane-1-carboxylate synthase 6	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9STR4	ACS7	1-aminocyclopropane-1-carboxylate synthase 7	Arabidopsis thaliana (Mouse-ear cress)	PR
Q06402	ACS2	1-aminocyclopropane-1-carboxylate synthase 2	Arabidopsis thaliana (Mouse-ear cress)	PR