AiPD: Autoinhibited Protein Database

Gene name	Sh2d3c (Chat, Shep1)
Protein name	SH2 domain-containing protein 3C
Names	Cas/HEF1-associated signal transducer, SH2 domain-containing Eph receptor-binding protein 1
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:27387
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-233 (Predicted disordered autoinhibitory region) PR

1-233 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9QZS8-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388548116	11	K>M	No	EVA
rs3391307570	72	D>A	No	EVA
rs3391445632	73	M>L	No	EVA
rs247000946	101	S>I	No	EVA
rs1132686343	109	R>Q	No	EVA
rs257721412	115	P>L	No	EVA
rs226828653	131	L>P	No	EVA
rs3388547545	134	T>M	No	EVA
rs244510119	135	A>V	No	EVA
rs3388545234	185	K>N	No	EVA
rs3388541160	190	S>T	No	EVA
rs3388548571	211	R>H	No	EVA
rs3388545507	216	Y>F	No	EVA
rs3388545478	242	T>I	No	EVA
rs3391412662	291	L>H	No	EVA
rs3391421959	296	V>E	No	EVA
rs3388543802	297	G>C	No	EVA
rs3388545431	312	C>S	No	EVA
rs3391454272	370	D>H	No	EVA
rs3391380627	371	G>R	No	EVA
rs3388547515	388	C>F	No	EVA
rs3388544127	426	T>I	No	EVA
rs257219827	427	P>H	No	EVA
rs27207944	451	T>A	No	EVA
rs242928396	452	P>S	No	EVA
rs213093176	461	A>G	No	EVA
rs583419050	462	P>S	No	EVA
rs583419050	462	P>T	No	EVA
rs236420539	464	A>G	No	EVA
rs3388548090	464	A>P	No	EVA
rs3388543499	476	S>*	No	EVA
rs3388545417	476	S>P	No	EVA
rs3388541098	484	D>V	No	EVA
rs3391451759	534	K>Q	No	EVA
rs220602620	537	T>I	No	EVA
rs3388545412	541	V>I	No	EVA
rs3388549127	584	L>P	No	EVA
rs3388548112	606	Q>H	No	EVA
rs3388538740	704	R>*	No	EVA
rs3388544088	708	G>D	No	EVA
rs13469758	718	P>L	No	EVA
rs3388548543	739	H>L	No	EVA
rs3388546468	748	E>D	No	EVA
rs3388544096	767	V>A	No	EVA

Type	Name	Position	InterPro Accession
domain	Rhodanese-like domain	113 - 217	IPR001763
domain	Rhodanase, C-terminal	220 - 286	IPR022111
domain	tRNA uridine(34) hydroxylase, N-terminal	3 - 94	IPR040503

		Description
EC Number
Subcellular Localization	Cytoplasm Cell membrane ; Peripheral membrane protein Cell projection, axon Cell projection, ruffle membrane	Associated with the membrane when EGF-stimulated (PubMed:10692442) Expressed at the cortical actin ring in B cells (PubMed:20956287)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
axon	The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
ruffle membrane	The portion of the plasma membrane surrounding a ruffle.

Name	Definition
guanyl-nucleotide exchange factor activity	Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
phosphotyrosine residue binding	Binding to a phosphorylated tyrosine residue within a protein.
transmembrane receptor protein tyrosine kinase adaptor activity	The binding activity of a molecule that brings together a transmembrane receptor protein tyrosine kinase and one or more other molecules, permitting them to function in a coordinated way.

Name	Definition
positive regulation of peptidyl-serine phosphorylation	Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
small GTPase mediated signal transduction	The series of molecular signals in which a small monomeric GTPase relays a signal.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q58DL5	BCAR3	Breast cancer anti-estrogen resistance protein 3 homolog	Bos taurus (Bovine)	PR
O75815	BCAR3	Breast cancer anti-estrogen resistance protein 3	Homo sapiens (Human)	PR
Q9BRG2	SH2D3A	SH2 domain-containing protein 3A	Homo sapiens (Human)	PR
Q8N5H7	SH2D3C	SH2 domain-containing protein 3C	Homo sapiens (Human)	PR
Q9QZK2	Bcar3	Breast cancer anti-estrogen resistance protein 3 homolog	Mus musculus (Mouse)	PR