Q58DL5

PR
Gene name
BCAR3
Protein name
Breast cancer anti-estrogen resistance protein 3 homolog
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:506231
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

270-439 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q58DL5

Entry ID Method Resolution Chain Position Source
AF-Q58DL5-F1 Predicted AlphaFoldDB

No variants for Q58DL5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q58DL5

No associated diseases with Q58DL5

3 regional properties for Q58DL5

Type Name Position InterPro Accession
domain SH2 domain 152 - 253 IPR000980
domain Ras guanine-nucleotide exchange factors catalytic domain 545 - 820 IPR001895
domain SHEP1/BCAR3/NSP1, SH2 domain 148 - 282 IPR044102

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cell junction, focal adhesion
  • Localization to focal adhesions depends on interaction with PTPRA
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
focal adhesion A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

2 GO annotations of molecular function

Name Definition
guanyl-nucleotide exchange factor activity Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
phosphotyrosine residue binding Binding to a phosphorylated tyrosine residue within a protein.

8 GO annotations of biological process

Name Definition
endothelin receptor signaling pathway A G protein-coupled receptor signaling pathway initiated by endothelin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
insulin receptor signaling pathway The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
positive regulation of DNA replication Any process that activates or increases the frequency, rate or extent of DNA replication.
positive regulation of epidermal growth factor receptor signaling pathway Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
positive regulation of GTPase activity Any process that activates or increases the activity of a GTPase.
positive regulation of MAPK cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
positive regulation of peptidyl-serine phosphorylation Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.
small GTPase mediated signal transduction The series of molecular signals in which a small monomeric GTPase relays a signal.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8N5H7 SH2D3C SH2 domain-containing protein 3C Homo sapiens (Human) PR
O75815 BCAR3 Breast cancer anti-estrogen resistance protein 3 Homo sapiens (Human) PR
Q9QZS8 Sh2d3c SH2 domain-containing protein 3C Mus musculus (Mouse) PR
Q9QZK2 Bcar3 Breast cancer anti-estrogen resistance protein 3 homolog Mus musculus (Mouse) PR
10 20 30 40 50 60
MAAGKFASLP RNMPVNHQFP LASSMDLLSS KSPLVERRAD AYQDVSIHGT LPRKKKGPPP
70 80 90 100 110 120
IRSCDNFSHV GTLPHSRSPR HHSPLIQDVI QEQPLQDWKG EAFTFRDQHL LDPTLEYVKF
130 140 150 160 170 180
SKERHVMDRT PERLKKELEE ELLLSSEDLR SHAWYHGRIP RQVSENLMQR DGDFLVRDSL
190 200 210 220 230 240
SSPGDFVLTC QWKNLPQHFK IRRTVVRLSE AYSRVQYQFE MESFDSIPGL VRCYVGNRRP
250 260 270 280 290 300
ISQQSGAIIF QPVNRTVPLR CLEERYGASS PDRAHEGSLT EGRPDAAKRL SLTVGGTQAR
310 320 330 340 350 360
EQGLPRGNLL RNKEKSGSQP ACLDHMQDRR ALSLKAHQSE SYLPIGGKLT PQSPSVGTSP
370 380 390 400 410 420
CPNSPVFRTG SEPTLSPAVV RRVSSDARPG EALRGSDSQL CPKPPPKPCK APLLKAPPSP
430 440 450 460 470 480
SIWLNSEANY CELNPALAAS YDGASRLPFC AQDSYVELLT AKQNGGLGTR NSDTSYLILD
490 500 510 520 530 540
DDDRTRPWKP PPAPGDTVGE DQDTFVMPLL ETTSSFKPND FESKLLPPEN KPLETSMLKR
550 560 570 580 590 600
AKELFTNSDP KVIAQHLLSV DCKVARILEV SEEMRKNMGV NSGLELITLP YGHQLRLDII
610 620 630 640 650 660
ERHNTMAIGI AVDILGCTGS LEDRAATLNK IIQVAVELKD SMGDLYSFSA IMKALEMPQI
670 680 690 700 710 720
TRLEKTWTAL RHQYTQTAIL YEKQLKPFSK VLHEGRESTC VPPNNVSVPL LMPLVTLMER
730 740 750 760 770 780
EAVTFEGTDM WEKNDESCEI MLNHLATARL MAEAADSYRM NAERILAGFQ PDEEMSEVFK
790 800 810 820
TEFQMRLLWG SKGAQVNQTE RYEKFNQILT ALSRKLEPPP VKQMEF