Q9QZK2
PR
Gene name |
Bcar3 (And34) |
Protein name |
Breast cancer anti-estrogen resistance protein 3 homolog |
Names |
p130Cas-binding protein AND-34 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:29815 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9QZK2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9QZK2-F1 | Predicted | AlphaFoldDB |
36 variants for Q9QZK2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388665601 | 11 | R>T | No | EVA | |
| rs3388650226 | 46 | S>T | No | EVA | |
| rs3388649675 | 103 | Y>N | No | EVA | |
| rs3388658962 | 105 | L>Q | No | EVA | |
| rs3388649693 | 190 | A>T | No | EVA | |
| rs3388658906 | 204 | E>D | No | EVA | |
| rs3388658588 | 212 | Q>R | No | EVA | |
| rs232781871 | 268 | R>Q | No | EVA | |
| rs3388650218 | 280 | V>L | No | EVA | |
| rs30991161 | 283 | L>Q | No | EVA | |
| rs36777945 | 293 | A>V | No | EVA | |
| rs3388658222 | 294 | R>W | No | EVA | |
| rs37128499 | 299 | P>A | No | EVA | |
| rs3388650229 | 315 | A>T | No | EVA | |
| rs233842403 | 320 | V>M | No | EVA | |
| rs45808147 | 355 | C>W | No | EVA | |
| rs218963996 | 357 | S>N | No | EVA | |
| rs231834660 | 410 | T>A | No | EVA | |
| rs3388655767 | 411 | P>S | No | EVA | |
| rs3388659043 | 424 | Y>H | No | EVA | |
| rs3388665581 | 437 | R>K | No | EVA | |
| rs244516002 | 443 | M>I | No | EVA | |
| rs37114367 | 443 | M>T | No | EVA | |
| rs3388658198 | 451 | M>I | No | EVA | |
| rs51697073 | 461 | S>W | No | EVA | |
| rs3388662830 | 467 | G>A | No | EVA | |
| rs3388654320 | 481 | H>L | No | EVA | |
| rs238898770 | 487 | V>A | No | EVA | |
| rs3388650274 | 611 | C>S | No | EVA | |
| rs3393639512 | 741 | T>S | No | EVA | |
| rs3393558707 | 743 | R>M | No | EVA | |
| rs3393695518 | 744 | F>I | No | EVA | |
| rs3393558686 | 744 | F>Y | No | EVA | |
| rs3393581794 | 745 | M>L | No | EVA | |
| rs3388664745 | 780 | R>K | No | EVA | |
| rs3388650206 | 810 | L>I | No | EVA |
No associated diseases with Q9QZK2
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| focal adhesion | A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ). |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| guanyl-nucleotide exchange factor activity | Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. |
| kinase binding | Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group. |
| phosphotyrosine residue binding | Binding to a phosphorylated tyrosine residue within a protein. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| endothelin receptor signaling pathway | A G protein-coupled receptor signaling pathway initiated by endothelin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| insulin receptor signaling pathway | The series of molecular signals generated as a consequence of the insulin receptor binding to insulin. |
| lens morphogenesis in camera-type eye | The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus. |
| positive regulation of DNA replication | Any process that activates or increases the frequency, rate or extent of DNA replication. |
| positive regulation of epidermal growth factor receptor signaling pathway | Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity. |
| positive regulation of GTPase activity | Any process that activates or increases the activity of a GTPase. |
| positive regulation of MAPK cascade | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. |
| positive regulation of peptidyl-serine phosphorylation | Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine. |
| small GTPase mediated signal transduction | The series of molecular signals in which a small monomeric GTPase relays a signal. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q58DL5 | BCAR3 | Breast cancer anti-estrogen resistance protein 3 homolog | Bos taurus (Bovine) | PR |
| Q8N5H7 | SH2D3C | SH2 domain-containing protein 3C | Homo sapiens (Human) | PR |
| Q9BRG2 | SH2D3A | SH2 domain-containing protein 3A | Homo sapiens (Human) | PR |
| O75815 | BCAR3 | Breast cancer anti-estrogen resistance protein 3 | Homo sapiens (Human) | PR |
| Q9QZS8 | Sh2d3c | SH2 domain-containing protein 3C | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAGKFASLP | RNMPVNHQFP | LASSMDLLSS | KSPLAERRTD | AYQDVSIHGT | LPRKKKGPPS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IRSCDNAGHS | KSPRQSSPLT | QDIIQENPLQ | DRKGENFIFR | DPYLLDPTLE | YVKFSKERHI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MDRTPERLKK | ELEEELLLSS | EDLRSHAWYH | GRIPRQVSEN | LVQRDGDFLV | RDSLSSPGNF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VLTCQWKNLA | QHFKINRTVL | RLSEAYSRVQ | YQFEMESFDS | IPGLVRCYVG | NRRPISQQSG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AIIFQPINRT | VPLWCLEERY | GTSPGRGREG | SLAEGRPDVV | KRLSLTTGSS | IQAREHSLPR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GNLLRNKEKS | GSQPACLDHV | QDRKALTLKA | HQSESHLPIG | CKLPPQSPSM | DTSPCPSSPV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FRTGSEPTLS | PALVRRFSSD | ARTGEALRGS | DSQLCPKPPP | KPCKVPFLKT | PPSPSPWLTS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EANYCELNPA | FAVGCDRGAK | LPMQAHDSHE | MLLTAKQNGP | SGPRNSGINY | MILDGDDQAR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| HWDPLAVQTD | EGQEDKTKFV | PPLMETVSSF | RPNDFESKLL | PPENKPLETA | MLKHAKELFT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| NHDARVIAQH | MLSVDCKVAR | ILEVSEDRKR | SMGVSSGLEL | ITLPHGRQLR | LDIIERHNTM |
| 610 | 620 | 630 | 640 | 650 | 660 |
| AIGIAVDILG | CTGTLENRAG | TLNKIIQVAV | ELKDAMGDLY | AFSAIMKALE | MPQITRLEKT |
| 670 | 680 | 690 | 700 | 710 | 720 |
| WTALRHHYTQ | TAILYEKQLK | PFSKILHEGR | ESTYVPASNV | SVPLLMPLVT | LMERQAVTFE |
| 730 | 740 | 750 | 760 | 770 | 780 |
| GTDMWENNDE | SCEILLNHLA | TARFMAEASE | SYRMNAERIL | ADFQPDEEMT | EILRTEFQMR |
| 790 | 800 | 810 | |||
| LLWGSKGAEV | NQNERYDKFN | QILTALSRKL | EPPSGKQAEL |