AiPD: Autoinhibited Protein Database

O75815

Gene name	BCAR3 (NSP2, SH2D3B, UNQ271/PRO308)
Protein name	Breast cancer anti-estrogen resistance protein 3
Names	Novel SH2-containing protein 2, SH2 domain-containing protein 3B
Species	Homo sapiens (Human)
KEGG Pathway	hsa:8412
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

3-116 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

3-116 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for O75815

Entry ID	Method	Resolution	Chain	Position	Source
3T6A	X-ray	240 A	A/B/C/D	502-825	PDB
AF-O75815-F1	Predicted				AlphaFoldDB

701 variants for O75815

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1455153382 CA341361729	2	A>V		No	ClinGen gnomAD
rs201541851 CA956007	3	A>G		No	ClinGen ExAC gnomAD
rs746582573 CA27164323	3	A>T		No	ClinGen Ensembl
rs972946363 CA27164320	5	K>I		No	ClinGen TOPMed
rs1227969371 CA341361705	6	F>L		No	ClinGen gnomAD
rs151322895 CA956006	6	F>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA956005 rs779717505	8	S>N		No	ClinGen ExAC TOPMed gnomAD
rs1435872626 CA341361680	10	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1365929176 CA341361677	11	R>K		No	ClinGen gnomAD
rs755722083 CA956004	12	N>K		No	ClinGen ExAC gnomAD
rs745540392 CA956003	13	M>V		No	ClinGen ExAC gnomAD
CA956002 rs772621684	14	P>L		No	ClinGen ExAC TOPMed gnomAD
rs756756546 CA341361631 CA341361632	17	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA341361630 rs1170005444	18	Q>K		No	ClinGen gnomAD
rs751128356 CA955999	19	F>L		No	ClinGen ExAC gnomAD
CA341361621 rs751128356	19	F>V		No	ClinGen ExAC gnomAD
TCGA novel	22	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA955997 rs371020036	24	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs758838087 CA955996	25	M>T		No	ClinGen ExAC gnomAD
CA341361587 rs1480531993	25	M>V		No	ClinGen TOPMed gnomAD
rs988166056 CA27164318	27	L>I		No	ClinGen Ensembl
CA955995 rs367834080	28	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA27164317 rs867162991	31	R>G		No	ClinGen TOPMed
CA955991 rs766770453	35	A>S		No	ClinGen ExAC TOPMed gnomAD
CA341361522 rs766770453	35	A>T		No	ClinGen ExAC TOPMed gnomAD
CA341361511 rs1217440680	36	E>D		No	ClinGen gnomAD
CA27164315 rs974770735	36	E>K		No	ClinGen TOPMed
rs144928860 CA955990	37	H>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs144928860 CA341361506	37	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA955989 rs111346378	38	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA955988 COSM913415 rs202034375	38	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs1368389547 CA341361490	40	D>G		No	ClinGen gnomAD
rs1571033426 CA341361492	40	D>H		No	ClinGen Ensembl
rs775304793 CA955986	41	A>G		No	ClinGen ExAC TOPMed gnomAD
CA341361485 rs1309479901	41	A>T		No	ClinGen TOPMed gnomAD
rs775304793 CA955987	41	A>V		No	ClinGen ExAC TOPMed gnomAD
rs769547395 CA341361447	46	S>C		No	ClinGen ExAC gnomAD
CA955984 rs769547395	46	S>F		No	ClinGen ExAC gnomAD
CA955982 rs780810028	47	I>V		No	ClinGen ExAC TOPMed gnomAD
rs770584562 CA955980	48	H>R		No	ClinGen ExAC gnomAD
CA341361430 rs1206172281 COSM198554	49	G>D	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA341361427 rs1571033349	50	T>P		No	ClinGen Ensembl
CA341361421 rs1483027319	51	L>I		No	ClinGen gnomAD
CA341361407 rs777183149	53	R>L		No	ClinGen ExAC gnomAD
rs777183149 CA955978	53	R>Q		No	ClinGen ExAC gnomAD
rs746465101 CA955979	53	R>W		No	ClinGen ExAC gnomAD
CA341361399 COSM1667714 rs1218493045	54	K>N	ovary Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA341361394 rs1227639691	55	K>R		No	ClinGen gnomAD
CA955977 rs758891472	57	G>D		No	ClinGen ExAC gnomAD
CA341361374 rs1203867650	58	P>L		No	ClinGen TOPMed
CA341361367 rs1456108184	59	P>L		No	ClinGen TOPMed
CA955976 rs753125244	59	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs755388139 CA955974	60	P>A		No	ClinGen ExAC TOPMed gnomAD
CA955973 rs754308137	60	P>R		No	ClinGen ExAC gnomAD
CA955972 rs766647597	61	I>V		No	ClinGen ExAC TOPMed gnomAD
rs760982104 CA341361350	62	R>S		No	ClinGen ExAC TOPMed gnomAD
rs534916474 CA27164312	63	S>F		No	ClinGen gnomAD
rs139529955 CA341361344	64	C>R		No	ClinGen ESP TOPMed gnomAD
CA27164311 rs139529955	64	C>S		No	ClinGen ESP TOPMed gnomAD
CA955970 rs750476398	64	C>Y		No	ClinGen ExAC gnomAD
rs767514429 CA955969	68	S>R		No	ClinGen ExAC
CA341361290 rs1470442522	71	G>S		No	ClinGen TOPMed
CA341361276 rs1467283654	73	L>F		No	ClinGen TOPMed
CA955968 rs762001108	73	L>H		No	ClinGen ExAC TOPMed gnomAD
rs141721897 CA955964	75	H>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs141721897 CA955966	75	H>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA955965 rs141721897	75	H>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA955963 rs563397599	77	K>R		No	ClinGen 1000Genomes ExAC gnomAD
CA27164308 rs749596481	80	R>Q		No	ClinGen TOPMed gnomAD
rs771455481 CA955960 COSM1184540	80	R>W	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA341361232 rs1315683385	81	Q>*		No	ClinGen TOPMed
CA341361230 rs1557649986	81	Q>R		No	ClinGen Ensembl
rs370836321 CA955959	83	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1397361066 CA341361213	84	P>T		No	ClinGen gnomAD
rs755552707 CA955957	87	Q>P		No	ClinGen ExAC TOPMed gnomAD
CA341361178 rs1319259420	89	G>C		No	ClinGen gnomAD
CA955956 rs754187653	90	I>L		No	ClinGen ExAC gnomAD
rs1035610378 CA27164306	90	I>T		No	ClinGen TOPMed gnomAD
CA955955 rs780596160	91	Q>P		No	ClinGen ExAC gnomAD
rs756308329 COSM913414 CA955954	94	P>L	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA955953 rs750587834	95	W>R		No	ClinGen ExAC gnomAD
rs112584760 CA955952	96	Q>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1247526337 CA341361123	97	D>A		No	ClinGen TOPMed gnomAD
rs1247526337 CA341361122	97	D>G		No	ClinGen TOPMed gnomAD
TCGA novel	97	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs113071736 CA955950	98	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs138811422 CA955951	98	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs776366339 CA341361105	100	G>D		No	ClinGen ExAC gnomAD
CA955948 rs201873210	100	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs776366339 CA955947	100	G>V		No	ClinGen ExAC gnomAD
CA955945 COSM1344976 rs370899092	101	E>K	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA955944 rs772732357	104	T>N		No	ClinGen ExAC TOPMed gnomAD
CA341360850 rs1375850965	108	P>R		No	ClinGen gnomAD
CA955922 rs773949793	108	P>S		No	ClinGen ExAC gnomAD
CA955921 rs149161122	109	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs150434867 CA955920	111	L>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA341360818 rs1250727188	113	P>L		No	ClinGen gnomAD
rs1482429086 CA341360821	113	P>S		No	ClinGen Ensembl
rs1190871196 CA341360816	114	T>A		No	ClinGen TOPMed
rs1483808231 CA341360785	118	V>A		No	ClinGen gnomAD
CA341360783 rs1273145590	119	K>Q		No	ClinGen gnomAD
CA341360780 rs1266024909	119	K>T		No	ClinGen TOPMed
rs1216288045 CA341359767	126	I>L		No	ClinGen TOPMed gnomAD
CA955878 rs759011238	126	I>T		No	ClinGen ExAC gnomAD
rs1216288045 CA341359768	126	I>V		No	ClinGen TOPMed gnomAD
CA27155536 rs879059951	127	M>L		No	ClinGen TOPMed
rs777194461 CA955877	127	M>T		No	ClinGen ExAC gnomAD
CA341359749 rs1367133941	128	D>E		No	ClinGen gnomAD
CA27155535 rs941343350	130	T>I		No	ClinGen gnomAD
rs1570944412 CA341359740	130	T>P		No	ClinGen Ensembl
CA955874 rs200280259	132	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA27155534 rs1047131934	136	K>E		No	ClinGen Ensembl
CA955872 rs748421416	137	E>K		No	ClinGen ExAC
CA955871 rs779051725	141	E>*		No	ClinGen ExAC gnomAD
CA341359666 rs779051725	141	E>K		No	ClinGen ExAC gnomAD
rs768748770 CA955870	141	E>V		No	ClinGen ExAC gnomAD
rs749394399 CA955869	142	L>R		No	ClinGen ExAC gnomAD
CA341359650 rs1188622769	144	L>V		No	ClinGen TOPMed
CA341359643 rs1482173419	145	S>N		No	ClinGen gnomAD
rs757265824 CA955867	146	S>G		No	ClinGen ExAC gnomAD
rs1308077174 CA341359631	147	E>K		No	ClinGen TOPMed gnomAD
CA955865 rs777735238	149	L>P		No	ClinGen ExAC TOPMed gnomAD
rs758318530 CA955864	150	R>C		No	ClinGen ExAC TOPMed gnomAD
CA955862 rs768094406	150	R>H		No	ClinGen ExAC TOPMed gnomAD
CA955863 rs768094406	150	R>P		No	ClinGen ExAC TOPMed gnomAD
rs754501424 CA955861	151	S>R		No	ClinGen ExAC gnomAD
TCGA novel	153	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA955857 rs368469194	156	H>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs368839525 CA955855	157	G>S		No	ClinGen ExAC TOPMed gnomAD
rs374784683 CA955854	158	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA955853 rs147932660	158	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs768817148 CA341359547	159	I>M		No	ClinGen ExAC TOPMed gnomAD
CA955850 rs375150823	161	R>*		No	ClinGen ESP ExAC gnomAD
TCGA novel	161	R>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA341359539 rs1252925845	161	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA341359443 rs1363598025	163	V>L		No	ClinGen TOPMed
rs763106218 CA955832	164	S>A		No	ClinGen ExAC gnomAD
CA341359417 rs1382802813	167	L>V		No	ClinGen gnomAD
CA341359410 rs1311732508	168	V>L		No	ClinGen TOPMed
TCGA novel	169	Q>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1320491741 CA341359397	170	R>*	Variant assessed as Somatic; 5.004e-05 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA955831 rs775906391	170	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1387636759 CA341359383	172	G>D		No	ClinGen gnomAD
rs1289790834 CA341359379	173	D>H		No	ClinGen TOPMed gnomAD
CA27155226 rs999870732	176	V>D		No	ClinGen gnomAD
rs769965474 CA955830	177	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA955829 rs142666440	177	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA341359317 rs1445317270	178	D>E		No	ClinGen gnomAD
rs1300664764 CA341359305	179	S>F		No	ClinGen gnomAD
CA955828 rs773271415	181	S>C		No	ClinGen ExAC TOPMed gnomAD
CA27155225 rs773271415	181	S>F		No	ClinGen ExAC TOPMed gnomAD
CA955826 rs558886347	182	S>R		No	ClinGen 1000Genomes ExAC gnomAD
rs778600216 CA955825	183	P>S		No	ClinGen ExAC gnomAD
rs768301429 CA955824	184	G>A		No	ClinGen ExAC gnomAD
rs1205479873 CA341359252	184	G>R		No	ClinGen gnomAD
CA955823 rs748914550	185	N>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	188	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA27155224 rs1018397481	188	L>V		No	ClinGen TOPMed gnomAD
CA341359174 rs1296176516	189	T>I		No	ClinGen gnomAD
rs1225932897 CA341359163	190	C>Y		No	ClinGen gnomAD
CA955821 rs755613955	191	Q>L		No	ClinGen ExAC gnomAD
CA341359088 rs1422446849	195	L>F		No	ClinGen TOPMed
rs200436960 CA341359074	196	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs200436960 CA955820	196	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs202125199 CA955819	196	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA341359061 rs1305200266	197	Q>R		No	ClinGen TOPMed gnomAD
CA341358995 rs1370058718	201	I>L		No	ClinGen gnomAD
rs375478012 CA955816	203	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs751903716 CA955817	203	R>W		No	ClinGen ExAC gnomAD
rs1247935069 CA341358955	205	V>F		No	ClinGen TOPMed
TCGA novel	206	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1430666938 CA341358948	206	L>R		No	ClinGen gnomAD
rs142078116 CA955815	207	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
RCV000966756 rs113172289 CA955812	210	E>K		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs113172289 CA955813	210	E>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA955811 rs776858691	211	A>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	212	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA341358876 rs1448817125	213	S>G		No	ClinGen TOPMed
rs772002067 CA955810	214	R>C		No	ClinGen ExAC TOPMed gnomAD
rs769831657 CA955809	214	R>H		No	ClinGen ExAC TOPMed gnomAD
CA27155222 rs769831657	214	R>L		No	ClinGen ExAC TOPMed gnomAD
rs139298422 CA27155221	215	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs139298422 CA955807	215	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA955806 rs749146552	216	Q>R		No	ClinGen ExAC gnomAD
CA341358806 rs1233087675	218	Q>H		No	ClinGen TOPMed gnomAD
CA955804 rs769449600	219	F>I		No	ClinGen ExAC gnomAD
CA955803 rs376886380	219	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA955802 rs190069670	220	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA955801 rs756840770	221	M>R		No	ClinGen ExAC TOPMed gnomAD
rs778412538 CA955799	222	E>D		No	ClinGen ExAC TOPMed gnomAD
CA955800 rs751980713	222	E>K		No	ClinGen ExAC TOPMed gnomAD
CA341358760 rs751980713	222	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA341358704 rs1570939470	225	D>A		No	ClinGen Ensembl
rs61752468 CA955798	225	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA341358709 rs61752468	225	D>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1281224597 CA341358660	228	P>L		No	ClinGen TOPMed
rs148087483 CA955795	229	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA341358640 rs1201293984	230	L>R		No	ClinGen gnomAD
rs1480594961 CA341358635 CA341358636	231	V>L		No	ClinGen gnomAD
CA27155219 rs925862406	232	R>C		No	ClinGen gnomAD
CA955792 rs201705203	232	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs774148679 CA341358616	233	C>G		No	ClinGen ExAC gnomAD
rs774148679 CA955791	233	C>R		No	ClinGen ExAC gnomAD
rs35588942 CA955790	233	C>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA27155218 rs986897156	234	Y>C		No	ClinGen TOPMed
rs376976363 CA955788	235	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs769388241 CA955787	236	G>D		No	ClinGen ExAC gnomAD
rs75635406 CA27155217	237	N>T		No	ClinGen Ensembl
CA955786 rs201358526	238	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA341358561 rs201358526	238	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA955785 rs137969427	238	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA955783 rs371841836	239	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs770345633 CA955784	239	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1178412716 CA341358528	241	I>M		No	ClinGen gnomAD
CA341358530 rs1403803649	241	I>S		No	ClinGen gnomAD
rs1451888176 CA341358538	241	I>V		No	ClinGen gnomAD
CA341358524 rs1470130604	242	S>A		No	ClinGen gnomAD
rs778087104 CA955782	243	Q>K		No	ClinGen ExAC gnomAD
rs758983074 CA955781	243	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA341358471 rs1363914670	246	G>D		No	ClinGen gnomAD
CA955778 rs150484354	247	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs753973727 CA955777	248	I>V		No	ClinGen ExAC gnomAD
rs1012322279 CA27155215	249	I>T		No	ClinGen TOPMed
CA955775 rs756132846	256	T>M		No	ClinGen ExAC TOPMed gnomAD
rs374296101 CA27155213	257	V>M		No	ClinGen ESP
CA341358338 rs1283735442	258	P>R		No	ClinGen gnomAD
rs763870383 CA955773	258	P>S		No	ClinGen ExAC gnomAD
CA955770 rs139230782	260	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs775455387 CA955771	260	R>W		No	ClinGen ExAC TOPMed gnomAD
CA341358325 rs1453221779	261	C>Y		No	ClinGen gnomAD
CA955769 rs759394550	265	H>R		No	ClinGen ExAC
CA955768 rs776136824	267	G>S		No	ClinGen ExAC TOPMed gnomAD
rs746439935 CA955766	268	T>P		No	ClinGen ExAC gnomAD
CA955765 rs747331253	269	S>F		No	ClinGen ExAC TOPMed gnomAD
rs1194402535 CA341358264	270	P>L		No	ClinGen TOPMed
CA341358262 rs1442243031	271	G>S		No	ClinGen gnomAD
rs748639520 CA955763	272	Q>E		No	ClinGen ExAC gnomAD
rs1184785807 CA341358250	273	A>T		No	ClinGen gnomAD
rs139249000 CA341358242	274	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA955761 rs139249000	274	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs62001028 CA955762	274	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs749717638 CA955760	275	E>D		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	276	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA955759 rs2137623	279	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA27155210 rs910941559	281	G>R		No	ClinGen TOPMed
rs756361530 CA955758	283	P>L		No	ClinGen ExAC gnomAD
CA341358187 rs1220465171	283	P>S		No	ClinGen gnomAD
CA955754 rs752627611	288	R>K		No	ClinGen ExAC TOPMed gnomAD
CA27155209 rs890551701	288	R>S		No	ClinGen Ensembl
CA955753 rs765219365	290	S>G		No	ClinGen ExAC gnomAD
rs1345497031 CA341358142	290	S>R		No	ClinGen gnomAD
CA955752 rs143405033	290	S>T		No	ClinGen 1000Genomes ExAC gnomAD
rs200443024 CA955751	291	L>F		No	ClinGen 1000Genomes ExAC gnomAD
rs765911755 CA955750	292	T>I		No	ClinGen ExAC gnomAD
CA341358121 rs1366941246	294	G>S		No	ClinGen gnomAD
CA341358112 rs1163643323	295	G>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs115932818 CA955748	296	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA341358100 rs1570938913	297	Q>R		No	ClinGen Ensembl
CA341358089 rs1188738667	299	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA955747 rs367652107	299	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA27155208 rs925831275	300	E>K		No	ClinGen Ensembl
rs761473184 CA341358058	303	L>F		No	ClinGen ExAC TOPMed gnomAD
rs372046471 CA955743	306	G>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA955742 rs780497082	307	N>D		No	ClinGen ExAC TOPMed gnomAD
rs368488209 CA955741	307	N>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs746072280 CA955740	308	L>H		No	ClinGen ExAC TOPMed gnomAD
CA341274969 rs1291857084	313	E>G		No	ClinGen gnomAD
rs1350307820 CA341274955	315	S>T		No	ClinGen TOPMed
rs1405974333 CA341274946	316	G>D		No	ClinGen gnomAD
rs777856449 CA955715	318	Q>K		No	ClinGen ExAC gnomAD
rs1235363247 CA341274924	319	P>L		No	ClinGen TOPMed
CA955713 rs144882670	320	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	320	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs779919718 CA955712	321	C>Y		No	ClinGen ExAC gnomAD
rs767210703 CA955710	322	L>V		No	ClinGen ExAC gnomAD
TCGA novel	323	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA341274905 rs1458212435	323	D>Y		No	ClinGen gnomAD
CA955708 rs761587439	324	H>R		No	ClinGen ExAC gnomAD
rs751064191 CA955707	325	M>T		No	ClinGen ExAC gnomAD
rs763637477 CA955706	327	D>G		No	ClinGen ExAC TOPMed gnomAD
CA341274866 rs1468429424	328	R>T		No	ClinGen TOPMed
CA955705 rs762437239	329	R>K		No	ClinGen ExAC gnomAD
CA955704 rs776052693	332	S>F		No	ClinGen ExAC gnomAD
rs765677379 CA955703	333	L>F		No	ClinGen ExAC gnomAD
rs1240232898 CA341274835	333	L>P		No	ClinGen gnomAD
rs765677379 CA341274838	333	L>V		No	ClinGen ExAC gnomAD
rs1286165813 CA341274820	335	A>V		No	ClinGen TOPMed gnomAD
CA341274816 rs1381317048	336	H>P		No	ClinGen gnomAD
CA955702 rs371110361	338	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA26831700 rs965755739	340	S>C		No	ClinGen TOPMed gnomAD
rs777014697 CA955701	340	S>N		No	ClinGen ExAC gnomAD
CA341274788 rs777014697	340	S>T		No	ClinGen ExAC gnomAD
rs1288632251 CA341274781	341	Y>S		No	ClinGen gnomAD
rs773458842 CA955698	343	P>L		No	ClinGen ExAC TOPMed gnomAD
rs747213509 CA955699	343	P>S		No	ClinGen ExAC gnomAD
CA955697 rs772192196	344	I>T		No	ClinGen ExAC gnomAD
rs781319547 CA955673	345	G>D		No	ClinGen ExAC gnomAD
rs1034222794 CA26830968	346	C>R		No	ClinGen TOPMed gnomAD
CA26830937 rs1002786487	346	C>W		No	ClinGen TOPMed
rs201005104 CA955672	346	C>Y		No	ClinGen 1000Genomes ExAC gnomAD
CA341274462 rs1570931037	347	K>E		No	ClinGen Ensembl
CA341274460 rs1234418599	347	K>R		No	ClinGen TOPMed
rs1251165337 CA341274454	348	L>V		No	ClinGen TOPMed
rs546279583 CA955671	349	P>S		No	ClinGen ExAC TOPMed gnomAD
rs183057886 CA955669	350	P>S		No	ClinGen 1000Genomes ExAC gnomAD
CA955668 rs752199717	353	S>L		No	ClinGen ExAC gnomAD
rs143458770 CA955665	354	G>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1305103844 CA341274414	355	V>M		No	ClinGen gnomAD
CA26830897 rs945781350	356	D>A		No	ClinGen Ensembl
rs142961077 CA955664 RCV001812396	358	S>N		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1395788779 CA341274392	358	S>R		No	ClinGen gnomAD
CA26830895 rs988245328	359	P>S		No	ClinGen Ensembl
rs760974846 CA955663	360	C>G		No	ClinGen ExAC TOPMed gnomAD
rs767740925 CA955661	361	P>R		No	ClinGen ExAC TOPMed gnomAD
rs1266337338 CA341274356	364	P>H		No	ClinGen gnomAD
CA341274359 rs1479944849	364	P>T		No	ClinGen gnomAD
CA341274337 rs1451700311	367	R>K		No	ClinGen gnomAD
CA341274330 rs763193150	368	T>K		No	ClinGen ExAC TOPMed gnomAD
CA955657 rs763193150	368	T>M		No	ClinGen ExAC TOPMed gnomAD
rs768825761 CA955658	368	T>S		No	ClinGen ExAC TOPMed gnomAD
rs140733181 CA955654	371	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA955653 rs777448396	372	P>A		No	ClinGen ExAC TOPMed gnomAD
rs969789871 CA341274301	373	A>S		No	ClinGen TOPMed gnomAD
rs969789871 CA26830786	373	A>T		No	ClinGen TOPMed gnomAD
rs910922440 CA26830776	374	L>V		No	ClinGen TOPMed
CA341274286 rs1437280962	375	S>R		No	ClinGen gnomAD
CA341274285 rs1220868201	376	P>S		No	ClinGen TOPMed
CA955652 rs771948696	380	R>Q		No	ClinGen ExAC gnomAD
CA26830774 rs779491839	380	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA341274255 rs1389652235	381	R>T		No	ClinGen gnomAD
CA341274249 rs1331877984	382	V>F		No	ClinGen TOPMed gnomAD
rs1331877984 CA341274250	382	V>I		No	ClinGen TOPMed gnomAD
CA955647 rs780475040	386	A>S		No	ClinGen ExAC gnomAD
COSM913411 CA955648 rs780475040	386	A>T	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA341274215 rs1174002822	387	R>S		No	ClinGen gnomAD
CA341274211 rs1362765321	388	A>G		No	ClinGen gnomAD
CA955646 rs756648236	388	A>P		No	ClinGen ExAC gnomAD
CA955645 CA341274209 rs375645584	389	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA26830696 rs934253399	390	E>G		No	ClinGen TOPMed
rs767751704 CA955644	391	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1410207386 CA341274185	393	R>K		No	ClinGen Ensembl
rs1570930663 CA341274168	396	D>N		No	ClinGen Ensembl
CA955643 rs762278739	397	S>G		No	ClinGen ExAC gnomAD
rs751726491 CA955642	397	S>N		No	ClinGen ExAC gnomAD
TCGA novel	399	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	400	C>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA341274114 rs1201285560	403	P>L		No	ClinGen gnomAD
rs1265341111 CA341274117	403	P>S		No	ClinGen TOPMed gnomAD
rs1265341111 CA341274119	403	P>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA955641 rs372966690	404	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs763058568 CA955640	405	P>S		No	ClinGen ExAC gnomAD
rs1377668912 CA341274098	406	K>R		No	ClinGen gnomAD
CA955639 rs775742791	407	P>L		No	ClinGen ExAC gnomAD
rs28446112 CA26830660	408	C>R		No	ClinGen Ensembl
CA341274061 rs1015042958	410	V>L		No	ClinGen gnomAD
CA26830654 rs1015042958	410	V>M		No	ClinGen gnomAD
rs141567715 CA955636	411	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA341274047 rs141567715	411	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs200778656 CA955637	411	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA955634 rs771756224	414	K>Q		No	ClinGen ExAC TOPMed gnomAD
rs748029100 CA955633	415	V>F		No	ClinGen ExAC gnomAD
rs148367926 CA955632	417	S>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA341273905 rs1443287375	422	W>*		No	ClinGen gnomAD
CA341273899 rs1239630194	423	L>F		No	ClinGen gnomAD
CA955630 rs748759310	423	L>P		No	ClinGen ExAC gnomAD
CA955628 rs140209686	424	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA955627 rs140209686	424	N>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA341273844 rs1557843987	427	A>S		No	ClinGen Ensembl
rs1380479060 CA341273813	429	Y>*		No	ClinGen gnomAD
CA341273791 rs1448480679	431	E>A		No	ClinGen TOPMed gnomAD
CA341273797 rs1285809494	431	E>K		No	ClinGen gnomAD
rs1484630696 CA341273753	434	P>A		No	ClinGen TOPMed
CA26830561 rs867634610	434	P>L		No	ClinGen Ensembl
CA341273744 rs1360650285	434	P>L		No	ClinGen gnomAD
CA341273740 rs1162350558	435	A>P		No	ClinGen gnomAD
CA955621 rs374393884	435	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs758714430 CA955620	438	T>A		No	ClinGen ExAC gnomAD
CA341273685 rs1475305257	439	G>V		No	ClinGen gnomAD
rs1424417728 CA341273673	440	C>F		No	ClinGen TOPMed
rs368993972 CA955618	441	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA955617 rs759724227	443	G>E		No	ClinGen ExAC gnomAD
CA341273635 rs1488725535	443	G>R		No	ClinGen gnomAD
rs767507738 CA955615	444	A>T		No	ClinGen ExAC gnomAD
CA341273613 rs761451887	445	K>E		No	ClinGen ExAC TOPMed gnomAD
CA955614 rs761451887	445	K>Q		No	ClinGen ExAC TOPMed gnomAD
CA26830480 rs928174348	446	L>P		No	ClinGen Ensembl
rs768251210 CA955612	448	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA341273545 rs775164598	450	A>S		No	ClinGen ExAC TOPMed gnomAD
rs775164598 CA955610	450	A>T		No	ClinGen ExAC TOPMed gnomAD
CA955609 rs547694353	451	Q>R		No	ClinGen 1000Genomes ExAC gnomAD
CA341273502 rs1302061646	453	S>R		No	ClinGen gnomAD
CA341273491 rs1402573815	454	H>R		No	ClinGen gnomAD
rs781484698 CA955608	455	T>K		No	ClinGen ExAC gnomAD
rs781484698 CA955607	455	T>R		No	ClinGen ExAC gnomAD
TCGA novel	456	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs753999386 CA955606	456	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA341273463 rs1390308622	457	L>R		No	ClinGen TOPMed
CA26830421 rs766452742	459	T>I		No	ClinGen Ensembl
CA955605 rs140309627	463	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA955604 VAR_050689 rs12062278	464	E>G		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs758871826 CA955603	465	A>V		No	ClinGen ExAC gnomAD
CA341273373 rs1268446489	466	P>A		No	ClinGen gnomAD
rs1197472599 CA341273365	466	P>L		No	ClinGen gnomAD
CA341273359 rs1489520972	467	G>D		No	ClinGen gnomAD
rs1309473454 CA341273363	467	G>S		No	ClinGen gnomAD
rs1211984033 CA341273352	468	P>S		No	ClinGen TOPMed
rs138527879 CA955600	469	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA955599 rs138527879	469	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs765608888 CA955601	469	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1437142951 CA341273339	470	N>H		No	ClinGen gnomAD
rs1255984468 CA341273311	472	G>C		No	ClinGen gnomAD
rs1220233961 CA341273306	472	G>V		No	ClinGen gnomAD
CA955598 rs144741377	473	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA955597 rs762737725	475	Y>C		No	ClinGen ExAC gnomAD
CA341273283 rs1176100499	475	Y>H		No	ClinGen gnomAD
rs1353262395 CA341273233	479	D>V		No	ClinGen gnomAD
rs774324851 CA955596	480	D>N		No	ClinGen ExAC gnomAD
CA955595 rs149396478	480	D>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA955594 rs550240881	482	D>N		No	ClinGen 1000Genomes ExAC gnomAD
CA341273180 rs1178774267	484	E>K		No	ClinGen TOPMed
CA341273165 rs1360237433	485	R>K		No	ClinGen TOPMed
rs769501013 CA955592	486	P>S		No	ClinGen ExAC TOPMed gnomAD
CA341273147 rs1328647919	487	W>R		No	ClinGen TOPMed
rs745328827 CA955591	488	E>D		No	ClinGen ExAC TOPMed gnomAD
CA955590 rs776226561	490	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA955588 rs747484719	492	A>V		No	ClinGen ExAC gnomAD
CA341273070 rs1557843569	494	M>I		No	ClinGen Ensembl
CA955587 rs778488596	494	M>V		No	ClinGen ExAC gnomAD
rs1365063005 CA341273063	495	E>Q		No	ClinGen TOPMed
CA341273027 rs772548512 CA955586	497	G>R		No	ClinGen ExAC gnomAD
rs1301436929 CA341272945	501	K>R		No	ClinGen gnomAD
CA341272935 rs1222706772	502	G>R		No	ClinGen gnomAD
CA26830293 rs769691162	504	F>S		No	ClinGen TOPMed gnomAD
rs1570929695 CA341272906	504	F>V		No	ClinGen Ensembl
rs1448121249 CA341272895	505	V>M		No	ClinGen gnomAD
rs375604944 CA955583	506	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA341272869 rs1467827689	507	P>S		No	ClinGen TOPMed gnomAD
rs968639421 CA26830275	509	L>V		No	ClinGen TOPMed gnomAD
CA955580 rs751496023	512	V>I		No	ClinGen ExAC TOPMed gnomAD
CA955579 rs751496023	512	V>L		No	ClinGen ExAC TOPMed gnomAD
rs561393483 CA26830254	513	S>F		No	ClinGen 1000Genomes gnomAD
CA341272775 rs1193262953	514	S>A		No	ClinGen TOPMed
CA955578 rs138525821	514	S>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA955577 rs762678929	515	F>L		No	ClinGen ExAC gnomAD
rs1179896048 CA341272757	515	F>L		No	ClinGen gnomAD
rs752519228 CA955576	517	P>R		No	ClinGen ExAC gnomAD
rs764747428 CA955575	518	N>D		No	ClinGen ExAC TOPMed gnomAD
CA955574 rs759203304	518	N>S		No	ClinGen ExAC gnomAD
CA955572 rs200907769	519	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA341272717 rs1210857171	520	F>L		No	ClinGen gnomAD
rs1241570587 CA341272714	520	F>S		No	ClinGen gnomAD
rs1020163496 CA26830208	522	S>P		No	ClinGen TOPMed
CA955571 rs776565886	527	P>A		No	ClinGen ExAC TOPMed gnomAD
CA26830179 rs776565886	527	P>S		No	ClinGen ExAC TOPMed gnomAD
CA955570 rs367828594	528	E>D		No	ClinGen ESP ExAC gnomAD
CA955569 rs147997848	529	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1288533987 CA341272614	531	P>S		No	ClinGen gnomAD
rs748486479 CA955568	534	T>I		No	ClinGen ExAC gnomAD
rs905626282 CA26830172	534	T>S		No	ClinGen Ensembl
CA955566 rs768953701	536	M>L		No	ClinGen ExAC TOPMed gnomAD
rs200616305 CA26830149	536	M>T		No	ClinGen 1000Genomes
rs768953701 CA341272565	536	M>V		No	ClinGen ExAC TOPMed gnomAD
rs199987558 CA955565	539	R>C		No	ClinGen ExAC TOPMed gnomAD
rs143508660 CA26830148	539	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA TOPMed gnomAD
rs199987558 CA341272530	539	R>S		No	ClinGen ExAC TOPMed gnomAD
CA955564 rs780208352	540	A>T		No	ClinGen ExAC gnomAD
rs1185616705 CA341272513	541	K>E		No	ClinGen gnomAD
rs777621474 CA955561	544	F>V		No	ClinGen ExAC gnomAD
rs1264219096 CA341272446	546	N>D		No	ClinGen gnomAD
CA955560 rs758352871	547	N>H		No	ClinGen ExAC TOPMed gnomAD
rs765048777 CA955558	548	D>A		No	ClinGen ExAC gnomAD
COSM913409 CA341272409 rs1557843298	548	D>N	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA955556 rs753513831	549	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA955553 rs772883889	550	K>R		No	ClinGen ExAC gnomAD
rs772662965 CA955552	551	V>I		No	ClinGen ExAC gnomAD
rs1459354785 CA341272332	552	I>V		No	ClinGen gnomAD
CA955551 rs762390483	553	A>T		No	ClinGen ExAC gnomAD
CA955550 rs774763104	554	Q>*		No	ClinGen ExAC gnomAD
rs1425332341 CA341272294	554	Q>R		No	ClinGen gnomAD
rs749674466 CA955549 CA341272255	555	H>Q		No	ClinGen ExAC gnomAD
CA955547 rs575587868	556	V>I		No	ClinGen ExAC TOPMed gnomAD
rs781225763 CA955544	557	L>P		No	ClinGen ExAC gnomAD
TCGA novel	557	L>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs745898120 CA955545	557	L>V		No	ClinGen ExAC gnomAD
CA955543 rs757365063	558	S>N		No	ClinGen ExAC gnomAD
CA955541 rs778771461	559	M>I		No	ClinGen ExAC TOPMed gnomAD
rs1217184422 CA341272173	559	M>L		No	ClinGen gnomAD
CA955542 rs748110712	559	M>T		No	ClinGen ExAC TOPMed gnomAD
rs116545384 CA955540	561	C>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1329463591 CA341272092	561	C>W		No	ClinGen gnomAD
CA955527 rs776904312	567	L>F		No	ClinGen ExAC TOPMed gnomAD
CA26825902 rs150839082	567	L>P		No	ClinGen ESP TOPMed gnomAD
CA341271402 rs1335187874	572	E>*		No	ClinGen TOPMed gnomAD
CA341271403 rs1335187874	572	E>Q		No	ClinGen TOPMed gnomAD
CA341271389 CA955526 rs770983286	573	M>I		No	ClinGen ExAC gnomAD
CA955525 rs747069441	574	R>G		No	ClinGen ExAC TOPMed gnomAD
CA955524 rs778839573	574	R>S		No	ClinGen ExAC TOPMed gnomAD
rs754900116 CA955523	575	R>K		No	ClinGen ExAC TOPMed gnomAD
rs764367470	575	R>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs756016235 CA955519	577	M>I		No	ClinGen ExAC TOPMed gnomAD
rs779976382 CA955520	577	M>L		No	ClinGen ExAC TOPMed gnomAD
CA26825884 rs1045069031	577	M>T		No	ClinGen Ensembl
rs779976382 CA955521	577	M>V		No	ClinGen ExAC TOPMed gnomAD
rs767337640 CA955518	578	G>A		No	ClinGen ExAC gnomAD
rs767337640 CA955517	578	G>E		No	ClinGen ExAC gnomAD
CA955515 rs751035398	580	S>N		No	ClinGen ExAC gnomAD
rs1239236197 CA341271305	587	T>N		No	ClinGen gnomAD
rs1570918810 CA341271308	587	T>P		No	ClinGen Ensembl
rs200246434 CA955513	589	P>R		No	ClinGen ExAC gnomAD
TCGA novel	589	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs765579769 CA955511	591	G>A		No	ClinGen ExAC TOPMed gnomAD
rs765579769 CA341271280	591	G>E		No	ClinGen ExAC TOPMed gnomAD
rs776017261 CA955512	591	G>R		No	ClinGen ExAC TOPMed gnomAD
rs759950494 CA955510	592	H>P		No	ClinGen ExAC gnomAD
rs17110107 CA26825848 VAR_050690	593	Q>H		No	ClinGen UniProt TOPMed dbSNP
CA955509 rs776773073	595	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA341271237 rs1457195095	595	R>H		No	ClinGen TOPMed gnomAD
rs1457195095 CA341271234	595	R>L		No	ClinGen TOPMed gnomAD
CA955506 rs536719438	599	I>T		No	ClinGen 1000Genomes ExAC gnomAD
CA955507 rs760765672	599	I>V		No	ClinGen ExAC gnomAD
CA955505 rs772245403	601	R>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs146397531 CA955482	602	H>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA955481 rs137906211	603	N>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA341270169 rs1291848166	604	T>A		No	ClinGen gnomAD
CA341270170 rs1291848166	604	T>P		No	ClinGen gnomAD
rs777540480 CA955479	605	M>I		No	ClinGen ExAC gnomAD
rs746635877 CA955480	605	M>L		No	ClinGen ExAC gnomAD
CA955477 rs779348233	607	I>M		No	ClinGen ExAC gnomAD
rs369665872 CA955478	607	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs755495708 CA955475	608	G>S		No	ClinGen ExAC gnomAD
TCGA novel	609	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA341270122 rs1375835945	612	D>H		No	ClinGen TOPMed
rs1410751012 CA341270112	613	I>V		No	ClinGen TOPMed
CA26822788 rs754388397	617	T>K		No	ClinGen ExAC TOPMed gnomAD
rs754388397 CA955473	617	T>M		No	ClinGen ExAC TOPMed gnomAD
CA341270082 rs1173139089	618	G>D		No	ClinGen gnomAD
CA26822762 rs529105962	618	G>S		No	ClinGen 1000Genomes
CA341270070 rs1189546810	620	L>S		No	ClinGen gnomAD
CA341270057 rs1278680477	622	D>N		No	ClinGen TOPMed
rs1557836909 CA341270050	623	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs146027367 CA955469	623	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
RCV000883008 CA955468 rs147633962	624	A>V		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA341270019 rs1385494560	628	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs759525792 CA955464	634	A>V		No	ClinGen ExAC gnomAD
CA341269942 CA955462 rs139804620	639	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1275994277 CA341269944	639	D>G		No	ClinGen gnomAD
CA341269948 rs1481357243	639	D>N		No	ClinGen TOPMed
CA341269929 rs1375203849	641	M>I		No	ClinGen gnomAD
rs1409408993 CA341269935	641	M>V		No	ClinGen TOPMed
rs1459671189 CA341269910	644	L>F		No	ClinGen gnomAD
RCV000950609 CA955461 rs146602562	645	Y>C		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA341269904 rs1168429762	645	Y>H		No	ClinGen TOPMed
rs1466395168 CA341269897	646	S>A		No	ClinGen gnomAD
rs1358809609 CA341269880	648	S>L		No	ClinGen gnomAD
CA341269876 rs1174152760	649	A>G		No	ClinGen TOPMed gnomAD
CA341269874 rs1174152760	649	A>V		No	ClinGen TOPMed gnomAD
CA955460 rs372252150	650	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA955459 rs575537040	651	M>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs747604227 CA955458	654	L>M		No	ClinGen ExAC gnomAD
CA955457 rs368481630	654	L>P		No	ClinGen ESP ExAC gnomAD
TCGA novel	655	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	655	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA341269816 rs1407276647	658	Q>P		No	ClinGen TOPMed
CA341268608 rs1342503689	663	E>D		No	ClinGen gnomAD
rs1296365221 CA341268603	664	K>E		No	ClinGen TOPMed gnomAD
rs1382771517 CA341268601	664	K>R		No	ClinGen gnomAD
rs760635585 CA955418	665	T>M		No	ClinGen ExAC TOPMed gnomAD
rs761657137 CA955415	668	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1169575759 CA341268557	668	A>V		No	ClinGen TOPMed gnomAD
rs762330740 CA341268541	670	R>P		No	ClinGen ExAC gnomAD
CA955412 rs762330740	670	R>Q		No	ClinGen ExAC gnomAD
rs139715406 CA955413	670	R>W		No	ClinGen ESP ExAC
CA955411 rs775087565	671	H>Y		No	ClinGen ExAC gnomAD
CA955410 rs769238156	673	Y>N		No	ClinGen ExAC TOPMed gnomAD
CA341268502 rs1570903124	674	T>P		No	ClinGen Ensembl
rs374978077 CA955409	675	Q>R		No	ClinGen ESP ExAC gnomAD
CA341268480 rs1204326953	676	T>A		No	ClinGen TOPMed
CA955407 rs771362553	678	I>V		No	ClinGen ExAC TOPMed gnomAD
rs925263186 CA26819814	680	Y>C		No	ClinGen TOPMed
CA955406 rs747382431	681	E>Q		No	ClinGen ExAC
rs1232637474 CA341268376	685	K>R		No	ClinGen gnomAD
CA341268378 rs1232637474	685	K>T		No	ClinGen gnomAD
rs1329369080 CA341268341	688	S>G		No	ClinGen gnomAD
TCGA novel	692	H>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1420291396 CA341268302	693	E>K		No	ClinGen TOPMed
CA341268294 rs1299150564	694	G>S		No	ClinGen gnomAD
CA955391 rs758980462	697	S>F		No	ClinGen ExAC TOPMed gnomAD
rs148402464 CA955390	698	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA341268248 rs1433250601	699	C>Y		No	ClinGen TOPMed
TCGA novel	705	V>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA955389 rs771595802	705	V>G		No	ClinGen ExAC gnomAD
CA341268202 rs1360301540	706	S>A		No	ClinGen TOPMed
CA955387 rs763985526	707	V>F		No	ClinGen ExAC TOPMed gnomAD
COSM228268 CA955385 rs748394785	708	P>L	skin [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA955384 rs779059824	711	M>K		No	ClinGen ExAC gnomAD
rs1487971464 CA341268166	712	P>L		No	ClinGen TOPMed gnomAD
CA341268168 rs1211692402	712	P>S		No	ClinGen gnomAD
rs1237828290 CA341268163	713	L>F		No	ClinGen gnomAD
CA955382 rs753923301	714	V>M		No	ClinGen ExAC gnomAD
CA341268152 rs1279907617	715	T>A		No	ClinGen gnomAD
CA341268149 rs145893320	715	T>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA955381 rs145893320	715	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs145893320 CA341268150	715	T>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs143581051 CA26819510	718	E>D		No	ClinGen ESP gnomAD
CA955379 COSM1238292 rs751548960	719	R>C	oesophagus [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA26819491 rs763920350	719	R>H		No	ClinGen ExAC TOPMed gnomAD
CA955378 rs763920350 COSM1246012	719	R>L	oesophagus [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1249750305 CA341268115	720	Q>H		No	ClinGen TOPMed
rs1452940862 CA341268070	727	T>S		No	ClinGen TOPMed
CA955374 rs759045700 COSM3401095 COSM3401096	728	D>N	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA955372 rs766032359	729	M>R		No	ClinGen ExAC TOPMed gnomAD
rs377698383 CA955373	729	M>V		No	ClinGen ESP ExAC gnomAD
CA955370 rs761229587	731	E>G		No	ClinGen ExAC TOPMed gnomAD
rs1188864980 COSM1344970 CA341268044	731	E>K	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA955369 RCV000961292 rs78349214	733	N>S		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA26819431 rs957157828	734	D>N		No	ClinGen Ensembl
CA955366 rs748477671	737	C>Y		No	ClinGen ExAC gnomAD
CA955365 rs774570055	738	E>K		No	ClinGen ExAC gnomAD
rs1353929747 CA341267972	740	M>I		No	ClinGen TOPMed gnomAD
TCGA novel	740	M>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA955363 rs768794679	742	N>D		No	ClinGen ExAC TOPMed gnomAD
CA26819408 rs200578746	745	A>T		No	ClinGen 1000Genomes gnomAD
rs749322059 CA955362	745	A>V		No	ClinGen ExAC gnomAD
rs532034172 CA955361	747	A>G		No	ClinGen 1000Genomes ExAC gnomAD
CA341267930 rs1361168549	747	A>T		No	ClinGen TOPMed
CA341267928 rs532034172	747	A>V		No	ClinGen 1000Genomes ExAC gnomAD
CA341267926 rs1182583496	748	R>*		No	ClinGen gnomAD
CA341267925 rs1275748004	748	R>P		No	ClinGen TOPMed gnomAD
CA341267924 rs1275748004	748	R>Q		No	ClinGen TOPMed gnomAD
CA955360 rs756227345	749	F>V		No	ClinGen ExAC gnomAD
CA341267908 rs1346312478	750	M>I		No	ClinGen gnomAD
rs746946088 CA955359	750	M>T		No	ClinGen ExAC
CA955358 rs777631950	751	A>T		No	ClinGen ExAC TOPMed gnomAD
rs185411561 CA26819382	751	A>V		No	ClinGen 1000Genomes
rs201785778 CA955355	752	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
COSM3952739 rs201785778 CA955356 COSM3952738	752	E>Q	ovary [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs754655432 CA955354	754	A>T		No	ClinGen ExAC gnomAD
rs919712226 CA26819369	755	D>A		No	ClinGen TOPMed
CA955353 rs753581756	756	S>N		No	ClinGen ExAC gnomAD
CA955351 rs140641625 RCV001812916	758	R>Q		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs765980154 CA955352	758	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1242655091 CA341267861	759	M>L		No	ClinGen gnomAD
rs773794690 CA955350	760	N>Y		No	ClinGen ExAC gnomAD
CA341267840 rs1213998119	761	A>V		No	ClinGen gnomAD
CA955348 rs762201005	762	E>K		No	ClinGen ExAC gnomAD
rs774605474 CA26819344	764	I>M		No	ClinGen ExAC TOPMed gnomAD
CA341267816 rs1361981931	765	L>P		No	ClinGen gnomAD
TCGA novel	766	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs149846383 CA955324	770	P>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1336194393 CA341267272	770	P>S		No	ClinGen TOPMed gnomAD
rs1416659361 CA341267262	771	D>E		No	ClinGen TOPMed
COSM913406 rs1375093904 CA341267269	771	D>N	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs759562164 CA955323	772	E>K		No	ClinGen ExAC gnomAD
TCGA novel	773	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA26815740 rs965616097	774	M>I		No	ClinGen TOPMed
CA341267235 rs1358716358	775	N>S		No	ClinGen gnomAD
rs150697615 CA955322	775	N>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs147155903 CA955321	776	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA341267230 rs1332271481	776	E>K		No	ClinGen TOPMed gnomAD
CA26815701 rs748027776	777	I>M		No	ClinGen ExAC TOPMed gnomAD
rs778964260 CA955319	778	C>G		No	ClinGen ExAC gnomAD
CA341267216 rs1438891972	778	C>S		No	ClinGen gnomAD
rs768510746 CA955318	779	K>R		No	ClinGen ExAC gnomAD
TCGA novel	779	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1480750965 CA341267199	780	T>I		No	ClinGen gnomAD
rs1236462674 CA341267197	781	E>K		No	ClinGen gnomAD
CA955316 rs749096646	785	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA955315 rs779816516	785	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs143568257 CA955311	789	G>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA341267134 rs1291606634	790	S>C		No	ClinGen TOPMed gnomAD
rs764599323 CA955309	790	S>N		No	ClinGen ExAC gnomAD
TCGA novel	791	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA341267118 rs1313454335	792	G>D		No	ClinGen gnomAD
TCGA novel	794	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA955307 rs763261459	796	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1343281668 CA341267081	797	Q>H		No	ClinGen gnomAD
rs1419388121 CA341267066	800	R>G		No	ClinGen TOPMed gnomAD
rs753081234 CA955306	801	Y>D		No	ClinGen ExAC TOPMed
CA341267055 rs1412643042	801	Y>F		No	ClinGen gnomAD
CA955305 rs144562250	802	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs759641595 CA955304	804	F>C		No	ClinGen ExAC gnomAD
rs1475925155 CA341267035	804	F>L		No	ClinGen gnomAD
CA955303 rs776977845	805	N>S		No	ClinGen ExAC gnomAD
rs769329876 CA26815602	806	Q>H		No	ClinGen Ensembl
CA341267019 rs1485177013	806	Q>R		No	ClinGen gnomAD
rs770901795 CA955302	811	L>F		No	ClinGen ExAC gnomAD
rs369490013 CA955301	812	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
COSM1627259 CA955298 rs367823753	813	R>C	liver [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA955297 COSM913405 rs373868471	813	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1404406823 CA341266969	814	K>N		No	ClinGen TOPMed
rs997152293 CA26815543	815	L>V		No	ClinGen Ensembl
rs769751257 CA955296	816	E>D		No	ClinGen ExAC TOPMed gnomAD
rs547841302 CA955295	817	P>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA341266952 rs1454144973	817	P>L		No	ClinGen gnomAD
rs1319878260 CA341266942	819	P>R		No	ClinGen TOPMed
CA955294 rs780958961	819	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1462679652 CA341266937	820	V>A		No	ClinGen gnomAD
CA955292 rs900177332	820	V>I		No	ClinGen gnomAD
CA26815510 rs900177332	820	V>L		No	ClinGen gnomAD
CA341266902 rs1192308751	825	L>P		No	ClinGen gnomAD
CA955291 rs756667714	825	L>V		No	ClinGen ExAC gnomAD

No associated diseases with O75815

No regional properties for O75815

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for O75815

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Cell junction, focal adhesion	Localization to focal adhesions depends on interaction with PTPRA
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
focal adhesion	A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

3 GO annotations of molecular function

Name	Definition
guanyl-nucleotide exchange factor activity	Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
kinase binding	Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group.
phosphotyrosine residue binding	Binding to a phosphorylated tyrosine residue within a protein.

11 GO annotations of biological process

Name	Definition
endothelin receptor signaling pathway	A G protein-coupled receptor signaling pathway initiated by endothelin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
insulin receptor signaling pathway	The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
lens morphogenesis in camera-type eye	The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.
positive regulation of DNA replication	Any process that activates or increases the frequency, rate or extent of DNA replication.
positive regulation of epidermal growth factor receptor signaling pathway	Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
positive regulation of GTPase activity	Any process that activates or increases the activity of a GTPase.
positive regulation of MAPK cascade	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
positive regulation of peptidyl-serine phosphorylation	Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.
response to xenobiotic stimulus	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
small GTPase mediated signal transduction	The series of molecular signals in which a small monomeric GTPase relays a signal.

5 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q58DL5	BCAR3	Breast cancer anti-estrogen resistance protein 3 homolog	Bos taurus (Bovine)	PR
Q8N5H7	SH2D3C	SH2 domain-containing protein 3C	Homo sapiens (Human)	PR
Q9BRG2	SH2D3A	SH2 domain-containing protein 3A	Homo sapiens (Human)	PR
Q9QZS8	Sh2d3c	SH2 domain-containing protein 3C	Mus musculus (Mouse)	PR
Q9QZK2	Bcar3	Breast cancer anti-estrogen resistance protein 3 homolog	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MAAGKFASLP	RNMPVNHQFP	LASSMDLLSS	RSPLAEHRPD	AYQDVSIHGT	LPRKKKGPPP
70	80	90	100	110	120
IRSCDDFSHM	GTLPHSKSPR	QNSPVTQDGI	QESPWQDRHG	ETFTFRDPHL	LDPTVEYVKF
130	140	150	160	170	180
SKERHIMDRT	PEKLKKELEE	ELLLSSEDLR	SHAWYHGRIP	RQVSENLVQR	DGDFLVRDSL
190	200	210	220	230	240
SSPGNFVLTC	QWKNLAQHFK	INRTVLRLSE	AYSRVQYQFE	MESFDSIPGL	VRCYVGNRRP
250	260	270	280	290	300
ISQQSGAIIF	QPINRTVPLR	CLEEHYGTSP	GQAREGSLTK	GRPDVAKRLS	LTMGGVQARE
310	320	330	340	350	360
QNLPRGNLLR	NKEKSGSQPA	CLDHMQDRRA	LSLKAHQSES	YLPIGCKLPP	QSSGVDTSPC
370	380	390	400	410	420
PNSPVFRTGS	EPALSPAVVR	RVSSDARAGE	ALRGSDSQLC	PKPPPKPCKV	PFLKVPSSPS
430	440	450	460	470	480
AWLNSEANYC	ELNPAFATGC	GRGAKLPSCA	QGSHTELLTA	KQNEAPGPRN	SGVNYLILDD
490	500	510	520	530	540
DDRERPWEPA	AAQMEKGQWD	KGEFVTPLLE	TVSSFRPNEF	ESKFLPPENK	PLETAMLKRA
550	560	570	580	590	600
KELFTNNDPK	VIAQHVLSMD	CRVARILGVS	EEMRRNMGVS	SGLELITLPH	GHQLRLDIIE
610	620	630	640	650	660
RHNTMAIGIA	VDILGCTGTL	EDRAATLSKI	IQVAVELKDS	MGDLYSFSAL	MKALEMPQIT
670	680	690	700	710	720
RLEKTWTALR	HQYTQTAILY	EKQLKPFSKL	LHEGRESTCV	PPNNVSVPLL	MPLVTLMERQ
730	740	750	760	770	780
AVTFEGTDMW	EKNDQSCEIM	LNHLATARFM	AEAADSYRMN	AERILAGFQP	DEEMNEICKT
790	800	810	820
EFQMRLLWGS	KGAQVNQTER	YEKFNQILTA	LSRKLEPPPV	KQAEL