Q9NAA5

PR
Gene name
Y53F4B.13
Protein name
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Names
Cap1 2'O-ribose methyltransferase 1, MTr1
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_Y53F4B.13
EC number
2.1.1.57: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

19-102 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9NAA5

Entry ID Method Resolution Chain Position Source
AF-Q9NAA5-F1 Predicted AlphaFoldDB

No variants for Q9NAA5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9NAA5

No associated diseases with Q9NAA5

3 regional properties for Q9NAA5

Type Name Position InterPro Accession
domain G-patch domain 84 - 132 IPR000467
domain Ribosomal RNA methyltransferase, FtsJ domain 237 - 463 IPR002877
domain RrmJ-type ribose 2-O-methyltransferase domain 236 - 465 IPR025816

Functions

Description
EC Number 2.1.1.57 Methyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
mRNA (nucleoside-2'-O-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine.
nucleic acid binding Binding to a nucleic acid.

3 GO annotations of biological process

Name Definition
7-methylguanosine mRNA capping Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript.
cap1 mRNA methylation Methylation of the ribose of the first nucleotide of a 5'-capped mRNA.
mRNA methylation The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A2VE39 CMTR1 Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 Bos taurus (Bovine) PR
D2HRF1 CMTR1 Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 Ailuropoda melanoleuca (Giant panda) PR
Q8N1G2 CMTR1 Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 Homo sapiens (Human) PR
Q9DBC3 Cmtr1 Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 Mus musculus (Mouse) PR
Q5U2Z5 Cmtr1 Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 Rattus norvegicus (Rat) PR
Q803R5 cmtr1 Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MADRKSDEGE DEYQHKEQMV TNRTSSFQPK STEDSISKLA KMRAADRREE FMEERASFSA
70 80 90 100 110 120
VKRGYQAGDD EEDDFTAEEE PPAKKPLTVA ERLMAAMGHK AGEGLGKHGQ GISEPIASST
130 140 150 160 170 180
QRGRTGLGHN AGKATARDFN EVWDETTEEK TVVERVEWMT DIEEEKRAEI CEQLKDDKWM
190 200 210 220 230 240
VIGKEKRTID DETKFCSQQS ITEMIEAKNV FDLMSDKDLR EARTRANPYE TIGSAFFQNR
250 260 270 280 290 300
AAMKTANMDK IYDWILSREN TENDRFLLKN PLQESQTAEN VDRSEDLFYF ADVCAGPGGF
310 320 330 340 350 360
SEYMLWRKGF YNAKGFGFTL AGKDDFKLFK FTASSQYFFE TFYGTKDNGD VMDPVNIDSL
370 380 390 400 410 420
EAHISRGTSG LGVHLMMADG GFSVEGQENI QEILSKRLYL CQLLVSLCIV REGGNFFCKL
430 440 450 460 470 480
FDIFTPFSVG LIYLMRVCYQ SVSLHKPHTS RPANSERYIT CKGLRKEFAN VVKEYLKRVN
490 500 510 520 530 540
RKLDELKNKK SHDDVTDLMP LDVIEADQIF MDEIIRHNEF LANRQTLYLR KYQSFAKNQG
550 560 570 580 590 600
QFDKDQGNLR DECLKYWQVP NKQRPRGGDR GNRHDNMQRL NPLQVYGKYC KKVCGESEIG
610 620 630 640 650 660
NTFPDFSLNC LDAPLPNIPY EEYRFVPLAS SGSPNLLIAA GDSAFIFRSG RFESISADHI
670 680 690 700 710 720
RIPENTILLV DWAEEVVRGD GNRIKISSEP QVVRIIDAAV LFGDDVSNLP YEERMKAAEK
730 740 750 760 770 780
FVAALKQTNR KVKKGWGHRA EMIKPHLKIC AKTYSLAELD EFRSNLEKLE HNRELAVLFT
790 800 810 820 830 840
EGEFTFRCQA LRFTRIIKQE WRMGWSKSQQ KPYAHSQEHQ NAGSIPVELW AEKSIYSSFW
850 860 870 880 890 900
DSVICLNKDK KKLMEAMEHT KGKCPIPSSI WSWKACIRTP YGPEKILNYP EPFEGKPTIA
910
ALKAQIENTD LIVKRVRN