Q5U2Z5

PR
Gene name
Cmtr1 (Ftsjd2)
Protein name
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Names
Cap methyltransferase 1, Cap1 2'O-ribose methyltransferase 1, MTr1, FtsJ methyltransferase domain-containing protein 2
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:309656
EC number
2.1.1.57: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-148 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5U2Z5

Entry ID Method Resolution Chain Position Source
AF-Q5U2Z5-F1 Predicted AlphaFoldDB

No variants for Q5U2Z5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5U2Z5

No associated diseases with Q5U2Z5

3 regional properties for Q5U2Z5

Type Name Position InterPro Accession
conserved_site Terpene synthase, conserved site 611 - 625 IPR002365
domain Squalene cyclase, C-terminal 421 - 758 IPR032696
domain Squalene cyclase, N-terminal 106 - 409 IPR032697

Functions

Description
EC Number 2.1.1.57 Methyltransferases
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
mRNA (nucleoside-2'-O-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine.
nucleic acid binding Binding to a nucleic acid.

3 GO annotations of biological process

Name Definition
7-methylguanosine mRNA capping Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript.
cap1 mRNA methylation Methylation of the ribose of the first nucleotide of a 5'-capped mRNA.
mRNA methylation The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A2VE39 CMTR1 Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 Bos taurus (Bovine) PR
D2HRF1 CMTR1 Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 Ailuropoda melanoleuca (Giant panda) PR
Q8N1G2 CMTR1 Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 Homo sapiens (Human) PR
Q9DBC3 Cmtr1 Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 Mus musculus (Mouse) PR
Q9NAA5 Y53F4B.13 Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 Caenorhabditis elegans PR
Q803R5 cmtr1 Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MKRRTDPECT APLKKQKRIG ELARHLSSTS DDEPLSSVSH AAKASTTSLS GSDSETEGKQ
70 80 90 100 110 120
PCSDGFKDAF KADSLVEGTS SRYSMYNSVS QKLMAKMGFR EGEGLGKYSQ GRKDIVETSN
130 140 150 160 170 180
QKGRRGLGLT LQGFDQELNV DWRDEPEPNA CEQVSWFPEC TTEIPDSREM SDWMVVGKRK
190 200 210 220 230 240
MVIEDETEFC GEELLHSMLK CKSVFDILDG EEMRRARTRA NPYEMIRGVF FLNRAAMKMA
250 260 270 280 290 300
NMDFVFDRMF TNPLDSSGKP LLKESDIDLL YFADVCAGPG GFSEYVLWRR KWHAKGFGMT
310 320 330 340 350 360
LKGPNDFKLE DFYSASSELF EPYYGEGGVD GDGDITRPEN INAFRNFVLD NTDRKGVHFV
370 380 390 400 410 420
MADGGFSVEG QENLQEILSK QLLLCQFLMA LSVVRTGGHF VCKTFDLFTP FSVGLIYLLY
430 440 450 460 470 480
CCFERVCLFK PVTSRPANSE RYVVCKGLKV GIDDVREYLF SVNIQLNQLR NTDSDVNLVV
490 500 510 520 530 540
PLSVIKGDHE FNDYMIRSNE SYCSLQIKAL AKIHAFVQDT TLSEPRQAEI RKECLQLWEI
550 560 570 580 590 600
PDRARVAPSP SDPKFKFFEL IKDTDINIFS YKPTLLTAKT LEKIRPVLEY RCMVSGSEQK
610 620 630 640 650 660
FLLGLGKSQI YTWDGRQSDR WVKLDLKTEL PRDTLLCVEI VHELKGEGKA QRKISAIHIL
670 680 690 700 710 720
DVLVLNGSDV REQHFNQRIQ LAEKFVKAVS KPSRPDMNPI RVKEVYRLEE MEKIFVRLEM
730 740 750 760 770 780
KLIKGSGGTP KLSYTGRDDR HFVPTGVYIV RTVTEPWTMA FSKGWKKKFF YNKKTGESFF
790 800 810 820 830
TLPPESIAPF HTCYYTRLFW EWGDGFHMRD SQKPQDPDKL SKEDVLSFIQ SHNPLGP