A2VE39

PR
Gene name
CMTR1 (FTSJD2)
Protein name
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Names
Cap methyltransferase 1, Cap1 2'O-ribose methyltransferase 1, MTr1, FtsJ methyltransferase domain-containing protein 2
Species
Bos taurus (Bovine)
KEGG Pathway
bta:509620
EC number
2.1.1.57: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-162 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A2VE39

Entry ID Method Resolution Chain Position Source
AF-A2VE39-F1 Predicted AlphaFoldDB

114 variants for A2VE39

Variant ID(s) Position Change Description Diseaes Association Provenance
rs473458855 16 Q>H No EVA
rs444734412 34 E>D No EVA
rs463223637 39 V>G No EVA
rs481678636 40 N>H No EVA
rs442150212 40 N>K No EVA
rs468375604 101 K>N No EVA
rs435338358 102 E>D No EVA
rs433386381 156 S>P No EVA
rs475424985 181 K>T No EVA
rs383513612 182 M>I No EVA
rs460958405 183 I>L No EVA
rs474344162 187 E>Q No EVA
rs441288351 187 E>V No EVA
rs721047679 197 R>C No EVA
rs473034820 247 F>L No EVA
rs482019965 320 L>P No EVA
rs448916630 323 P>A No EVA
rs467348584 323 P>L No EVA
rs434338826 324 Y>H No EVA
rs452809808 325 Y>* No EVA
rs433710359 326 G>C No EVA
rs472213277 412 F>L No EVA
rs450322943 433 I>L No EVA
rs446380542 446 C>G No EVA
rs447940084 469 Q>K No EVA
rs800220343 490 H>R No EVA
rs475775228 527 R>W No EVA
rs436072046 528 Q>H No EVA
rs472891532 529 A>G No EVA
rs454504740 529 A>T No EVA
rs472891532 529 A>V No EVA
rs440031392 531 I>M No EVA
rs458544801 533 K>E No EVA
rs470872831 534 E>G No EVA
rs462766588 535 C>* No EVA
rs444277430 535 C>S No EVA
rs481188044 536 L>F No EVA
rs481188044 536 L>I No EVA
rs480368663 542 P>Q No EVA
rs452052446 565 T>P No EVA
rs476889490 567 I>L No EVA
rs462294497 568 D>G No EVA
rs443889849 568 D>N No EVA
rs480355765 569 I>V No EVA
rs459366513 572 Y>* No EVA
rs440857190 572 Y>N No EVA
rs477882454 574 P>T No EVA
rs469954117 578 T>I No EVA
rs481922545 583 E>D No EVA
rs467362152 585 I>S No EVA
rs876239191 591 Y>F No EVA
rs435700694 594 M>K No EVA
rs454114910 597 G>R No EVA
rs466262951 606 L>R No EVA
rs456536809 610 Q>E No EVA
rs474982735 613 T>R No EVA
rs441987906 615 D>H No EVA
rs441987906 615 D>N No EVA
rs454380394 616 G>V No EVA
rs472880866 631 L>V No EVA
rs439880329 634 D>G No EVA
rs458285008 639 V>L No EVA
rs482726555 647 G>R No EVA
rs456791443 653 R>G No EVA
rs475417545 656 S>R No EVA
rs477458580 681 Q>* No EVA
rs451083243 682 L>F No EVA
rs481182814 699 N>T No EVA
rs134127084 710 E>G No EVA
rs437363439 711 E>G No EVA
rs445621996 719 L>V No EVA
rs457970050 726 G>A No EVA
rs482929538 729 G>R No EVA
rs449820033 732 K>E No EVA
rs468179353 732 K>T No EVA
rs435336796 733 L>I No EVA
rs448530057 735 Y>S No EVA
rs466897516 742 H>Y No EVA
rs433973477 744 V>G No EVA
rs471285684 754 V>E No EVA
rs456806135 755 N>K No EVA
rs473036627 756 E>* No EVA
rs110585037 763 S>I No EVA
rs470236418 768 R>G No EVA
rs437341761 788 I>V No EVA
rs471165242 793 I>L No EVA
rs460444120 801 W>* No EVA
rs448083756 801 W>S No EVA
rs478940590 802 E>* No EVA
rs445821679 802 E>A No EVA
rs464384591 802 E>D No EVA
rs478940590 802 E>K No EVA
rs445821679 802 E>V No EVA
rs437720181 803 W>G No EVA
rs437720181 803 W>R No EVA
rs450905971 806 G>A No EVA
rs436398354 810 H>D No EVA
rs436398354 810 H>Y No EVA
rs473732348 813 Q>H No EVA
rs434299769 814 K>T No EVA
rs452692113 815 P>A No EVA
rs471202094 816 Q>L No EVA
rs444600905 817 D>V No EVA
rs456278015 818 P>A No EVA
rs456278015 818 P>T No EVA
rs441626640 819 D>A No EVA
rs460130545 820 K>N No EVA
rs478618021 821 L>V No EVA
rs439500546 822 S>P No EVA
rs482626214 824 E>K No EVA
rs482626214 824 E>Q No EVA
rs449788029 825 D>E No EVA
rs481303897 833 H>Q No EVA
rs448410555 836 A>W No EVA

No associated diseases with A2VE39

4 regional properties for A2VE39

Type Name Position InterPro Accession
domain G-patch domain 85 - 133 IPR000467
domain WW domain 752 - 786 IPR001202
domain Ribosomal RNA methyltransferase, FtsJ domain 233 - 448 IPR002877
domain RrmJ-type ribose 2-O-methyltransferase domain 231 - 450 IPR025816

Functions

Description
EC Number 2.1.1.57 Methyltransferases
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
mRNA (nucleoside-2'-O-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine.
nucleic acid binding Binding to a nucleic acid.

3 GO annotations of biological process

Name Definition
7-methylguanosine mRNA capping Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript.
cap1 mRNA methylation Methylation of the ribose of the first nucleotide of a 5'-capped mRNA.
mRNA methylation The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
D2HRF1 CMTR1 Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 Ailuropoda melanoleuca (Giant panda) PR
Q8N1G2 CMTR1 Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 Homo sapiens (Human) PR
Q9DBC3 Cmtr1 Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 Mus musculus (Mouse) PR
Q5U2Z5 Cmtr1 Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 Rattus norvegicus (Rat) PR
Q9NAA5 Y53F4B.13 Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 Caenorhabditis elegans PR
Q803R5 cmtr1 Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MKRRNDSECT APLKKQKKRV AELALSLSST SDDEPPSSVN HAAKASATSL SGSDSETEGK
70 80 90 100 110 120
QRSSDSFDDA FKADSLVEGT SSRYSMYNSV SQKLMAKMGF KEGEGLGKYS QGRKDIVEAS
130 140 150 160 170 180
NQKGRRGLGL TLQGFDQELN VNWRDEPEPS ACEQVSWFPE CTTEIPDTQE MSDWMVVGKR
190 200 210 220 230 240
KMIIEDETEF CGEGLLRSVL KCKSVFDVLD GEEMRRARTR ANPYEMIRGV FFLNRAAMKM
250 260 270 280 290 300
ANMDFVFDRM FTNPRDSYGK PLVKDREAEL LYFADVCAGP GGFSEYVLWR KRWHAKGFGL
310 320 330 340 350 360
TLKGPHDFKL EDFYSASSEL FEPYYGEGGI DGDGDITRPE NINAFRNFVL DNTDHKGVHF
370 380 390 400 410 420
LMADGGFSVE GQENLQEILS KQLLLCQFLM ALSVVRTGGH FICKTFDLFT PFSVGLIYLL
430 440 450 460 470 480
YCCFERVCLF KPITSRPANS ERYVVCKGLK VGIDEVRDYL FSVNIKLNQL RNTDSDVNLV
490 500 510 520 530 540
VPLEVIKGDH EFTDYMIRSN EGHCSLQIKA LAKIRAFVQD TTLIEPRQAE IRKECLRLWG
550 560 570 580 590 600
IPDQARVAPS STDPKSKFFE LIQGTEIDIF SYKPTPLTAK TLEKIRPVLD YRCMVSGSEQ
610 620 630 640 650 660
KFLIGLGKSQ IYTWDGRQSD RWVKLDLKTE LPRDTLLSVE IVHELKGEGK AQRKISAIHI
670 680 690 700 710 720
LDVLVLNGSD VREQHFNQRI QLAEKFVKAV SKPSRPDMNP IRVKEVYRLE EMEKIFVRLE
730 740 750 760 770 780
MKIIKGSSGT PKLSYTGRDD RHFVPTGLYI VRTVNEPWTM GFSKSFKRKF FYNKKTKNST
790 800 810 820 830
FDLPADAIAP FHICYYGRLF WEWGDGIRVH ESQKPQDPDK LSKEDVLSFI QTHSA