Q803R5
Gene name |
cmtr1 (ftsjd2, zgc:55336) |
Protein name |
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 |
Names |
Cap methyltransferase 1, Cap1 2'O-ribose methyltransferase 1, MTr1, FtsJ methyltransferase domain-containing protein 2 |
Species |
Danio rerio (Zebrafish) (Brachydanio rerio) |
KEGG Pathway |
dre:393102 |
EC number |
2.1.1.57: Methyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q803R5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q803R5-F1 | Predicted | AlphaFoldDB |
No variants for Q803R5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q803R5 | |||||
No associated diseases with Q803R5
5 regional properties for Q803R5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | C2 domain | 1 - 115 | IPR000008-1 |
| domain | C2 domain | 124 - 247 | IPR000008-2 |
| domain | von Willebrand factor, type A | 289 - 491 | IPR002035 |
| domain | Copine, C-terminal | 263 - 524 | IPR010734 |
| domain | Copine, C2B domain | 139 - 251 | IPR037768 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.57 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| mRNA (nucleoside-2'-O-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine. |
| nucleic acid binding | Binding to a nucleic acid. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| 7-methylguanosine mRNA capping | Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript. |
| cap1 mRNA methylation | Methylation of the ribose of the first nucleotide of a 5'-capped mRNA. |
| mRNA methylation | The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A2VE39 | CMTR1 | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 | Bos taurus (Bovine) | PR |
| D2HRF1 | CMTR1 | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 | Ailuropoda melanoleuca (Giant panda) | PR |
| Q8N1G2 | CMTR1 | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 | Homo sapiens (Human) | PR |
| Q9DBC3 | Cmtr1 | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 | Mus musculus (Mouse) | PR |
| Q5U2Z5 | Cmtr1 | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 | Rattus norvegicus (Rat) | PR |
| Q9NAA5 | Y53F4B.13 | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKRAAQASDE | PLKKRKTARE | ESSDEDEESS | QRTTSQDSSQ | SESLSDVEDH | KPSFSRPSDS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QNSQGSMAHN | EASNKFAMYN | NVSQKLMAKM | GFREGEGLGK | YGQGRKEIVE | ASTQRGRRGL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GLMLKGFQGD | LNVDWEDEPE | PSAIEQVSWF | PESSPEIPDS | DELRDWMTIG | EKKLKIDDEI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EFCSENLLHL | LLRCKTVFDD | LEGEEMRRAR | TRSNPYETIR | GAFFLNRAAM | KMANMDHVFD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YMFTNPKDSQ | GKVLTRDKEG | ELLYFGDVCA | GPGGFSEYVL | WRRRWHAKGF | GMTLKGANDF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KLEDFYAAPS | ELFEAYYGEG | GIDGDGDITR | PENISAFRNF | VLDSTEGRGL | HFLMADGGFS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VEGQENLQEI | LSKQLLLCQF | LTALSVVRPG | GHFLCKTFDL | FTPFSVGLIY | LLYLCFERVS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LFKPVTSRPA | NSERYVVCKG | LKPGTDAVRE | YMFTINLKLN | QFRHSDRDVI | EVVPLDIIKG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DTDFFQYMIG | SNESYCAVQI | KALAKIHAYV | RDTTLFEARQ | ADIRKECLKL | WGIPDKARVT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PSTSDPKNKF | YELVKGSEMD | SFNSRPTALN | SVNLEKLQHV | LDYRCIVGGG | EQLFLLALGR |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SQIYTWDGKA | PSRWKKLENF | KMELPRDTLL | SVEIVQELKG | EGKAQRRINA | VHVLDALVLN |
| 670 | 680 | 690 | 700 | 710 | 720 |
| GTDVRDQHFN | QRIQMVEKFV | KAVSKPSRPD | MNPIRVKEVY | RLEEMEKIFV | RLEMKITKSS |
| 730 | 740 | 750 | 760 | 770 | 780 |
| GGMPRLSYTG | RDDRHFLPTG | LYIIKTVNDP | WTMAFSKSSK | RKFFYNKQTK | ESTYDLPATS |
| 790 | 800 | 810 | 820 | ||
| VAPFYVCHQD | RLFWAWEEGV | RVHDSQTRIN | PDKLSKDDVV | SFIHKHYQQ |