Q9M274
Gene name |
NAC066 (NST2, At3g61910, F21F14.80) |
Protein name |
NAC domain-containing protein 66 |
Names |
ANAC066, Protein NAC SECONDARY WALL THICKENING PROMOTING FACTOR 2 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G61910 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9M274
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9M274-F1 | Predicted | AlphaFoldDB |
43 variants for Q9M274
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH00431616 | 9 | S>L | No | 1000Genomes | |
| ENSVATH14467862 | 13 | P>T | No | 1000Genomes | |
| ENSVATH12877578 | 30 | R>H | No | 1000Genomes | |
| tmp_3_22930259_T_A | 50 | K>M | No | 1000Genomes | |
| tmp_3_22930024_C_A | 58 | E>D | No | 1000Genomes | |
| tmp_3_22930007_G_A | 64 | T>M | No | 1000Genomes | |
| ENSVATH06358237 | 66 | P>A | No | 1000Genomes | |
| tmp_3_22930001_G_A | 66 | P>L | No | 1000Genomes | |
| ENSVATH06358237 | 66 | P>S | No | 1000Genomes | |
| ENSVATH12877575 | 69 | D>N | No | 1000Genomes | |
| ENSVATH12877575 | 69 | D>Y | No | 1000Genomes | |
| ENSVATH02535771 | 73 | Y>F | No | 1000Genomes | |
| tmp_3_22929930_T_A | 90 | T>S | No | 1000Genomes | |
| ENSVATH06358235 | 103 | T>I | No | 1000Genomes | |
| ENSVATH00431613 | 104 | I>V | No | 1000Genomes | |
| ENSVATH02535770 | 108 | G>D | No | 1000Genomes | |
| tmp_3_22929842_A_C | 119 | F>C | No | 1000Genomes | |
| ENSVATH06358233 | 143 | V>I | No | 1000Genomes | |
| tmp_3_22929752_C_T | 149 | G>D | No | 1000Genomes | |
| ENSVATH00431611 | 151 | H>D | No | 1000Genomes | |
| ENSVATH14467861 | 179 | C>W | No | 1000Genomes | |
| ENSVATH14467859 | 189 | S>N | No | 1000Genomes | |
| tmp_3_22929620_G_C | 193 | T>R | No | 1000Genomes | |
| ENSVATH12877533 | 210 | Q>K | No | 1000Genomes | |
| ENSVATH06358230 | 212 | C>F | No | 1000Genomes | |
| ENSVATH06358229 | 213 | K>R | No | 1000Genomes | |
| tmp_3_22929494_A_C | 235 | I>S | No | 1000Genomes | |
| ENSVATH06358228 | 236 | T>A | No | 1000Genomes | |
| tmp_3_22929479_C_T | 240 | W>* | No | 1000Genomes | |
| ENSVATH00431610 | 240 | W>R | No | 1000Genomes | |
| ENSVATH14467857 | 241 | L>F | No | 1000Genomes | |
| tmp_3_22929452_C_T | 249 | C>Y | No | 1000Genomes | |
| tmp_3_22929450_G_A | 250 | H>Y | No | 1000Genomes | |
| tmp_3_22929437_A_G | 254 | V>A | No | 1000Genomes | |
| tmp_3_22929434_A_G | 255 | M>T | No | 1000Genomes | |
| tmp_3_22929390_C_G | 270 | V>L | No | 1000Genomes | |
| ENSVATH00431609 | 282 | I>K | No | 1000Genomes | |
| ENSVATH00431608 | 286 | N>S | No | 1000Genomes | |
| ENSVATH06358226 | 299 | S>F | No | 1000Genomes | |
| ENSVATH00431607 | 302 | N>H | No | 1000Genomes | |
| tmp_3_22929279_G_C | 307 | P>A | No | 1000Genomes | |
| ENSVATH12877530 | 324 | R>I | No | 1000Genomes | |
| ENSVATH12877530 | 324 | R>K | No | 1000Genomes |
No associated diseases with Q9M274
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription factor activity | A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. |
| transcription cis-regulatory region binding | Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| plant-type secondary cell wall biogenesis | A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of inextensible cellulose- and pectin-containing cell walls that are formed between the plasma membrane and primary cell wall after cell expansion is complete. An example of this is found in Arabidopsis thaliana. |
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q84WP6 | NAC043 | NAC domain-containing protein 43 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C878 | BRN1 | Protein BEARSKIN1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FWX2 | NAC007 | NAC domain-containing protein 7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q5PP28 | NAC003 | NAC domain-containing protein 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| F4JN35 | NTL9 | Protein NTM1-like 9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNISVNGQSQ | VPPGFRFHPT | EEELLKYYLR | KKISNIKIDL | DVIPDIDLNK | LEPWDIQEMC |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KIGTTPQNDW | YFYSHKDKKY | PTGTRTNRAT | TVGFWKATGR | DKTIYTNGDR | IGMRKTLVFY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KGRAPHGQKS | DWIMHEYRLD | ESVLISSCGD | HDVNVETCDV | IGSDEGWVVC | RVFKKNNLCK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NMISSSPASS | VKTPSFNEET | IEQLLEVMGQ | SCKGEIVLDP | FLKLPNLECH | NNTTITSYQW |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LIDDQVNNCH | VSKVMDPSFI | TSWAALDRLV | ASQLNGPNSY | SIPAVNETSQ | SPYHGLNRSG |
| 310 | 320 | 330 | |||
| CNTGLTPDYY | IPEIDLWNEA | DFARTTCHLL | NGSG |