Q9LYU4
PR
Gene name |
GH3.12 (GDG1, PBS3, WIN3, At5g13320, T22N19.5, T31B5.140) |
Protein name |
4-substituted benzoates-glutamate ligase GH3.12 |
Names |
Auxin-responsive GH3-like protein 12, AtGH3-12, Protein GH3-LIKE DEFENSE GENE 1, Protein GRETCHEN HAGEN 3.12, Protein HOPW1-1-INTERACTING 3, Protein avrPPHB SUSCEPTIBLE 3 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G13320 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
23 variants for Q9LYU4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_5_4268914_T_C | 5 | F>L | No | 1000Genomes | |
| ENSVATH06962130 | 8 | N>T | No | 1000Genomes | |
| ENSVATH00620159 | 24 | S>P | No | 1000Genomes | |
| tmp_5_4268972_C_A | 24 | S>Y | No | 1000Genomes | |
| ENSVATH10729367 | 25 | I>T | No | 1000Genomes | |
| tmp_5_4269034_C_T | 45 | R>C | No | 1000Genomes | |
| ENSVATH14016094 | 54 | E>K | No | 1000Genomes | |
| ENSVATH00620160 | 87 | R>Q | No | 1000Genomes | |
| tmp_5_4269289_C_T | 102 | A>V | No | 1000Genomes | |
| ENSVATH06962140 | 129 | K>N | No | 1000Genomes | |
| tmp_5_4269467_A_G | 132 | K>R | No | 1000Genomes | |
| tmp_5_4270081_G_A | 337 | D>N | No | 1000Genomes | |
| ENSVATH10729369 | 345 | V>A | No | 1000Genomes | |
| ENSVATH10729370 | 346 | S>F | No | 1000Genomes | |
| ENSVATH10729371 | 404 | G>S | No | 1000Genomes | |
| ENSVATH06962147 | 408 | N>K | No | 1000Genomes | |
| ENSVATH06962148 | 409 | A>S | No | 1000Genomes | |
| tmp_5_4270552_T_A | 462 | S>T | No | 1000Genomes | |
| ENSVATH03053189 | 480 | E>D | No | 1000Genomes | |
| tmp_5_4270619_C_T | 484 | T>M | No | 1000Genomes | |
| ENSVATH14016156 | 518 | S>A | No | 1000Genomes | |
| tmp_5_4270756_G_A | 530 | G>R | No | 1000Genomes | |
| tmp_5_4270779_C_A | 537 | D>E | No | 1000Genomes |
No associated diseases with Q9LYU4
No regional properties for Q9LYU4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9LYU4 | |||
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| 4-aminobenzoate amino acid synthetase activity | Catalysis of the reaction: 4-aminobenzoate + ATP + amino acid = 4-aminobenzoyl amino acid conjugate + AMP + diphosphate. |
| 4-hydroxybenzoate amino acid synthetase activity | Catalysis of the reaction: 4-hydroxybenzoate + ATP + amino acid = 4-hydroxybenzoyl amino acid conjugate + AMP + diphosphate. |
| acid-amino acid ligase activity | Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. |
| benzoate amino acid synthetase activity | Catalysis of the reaction: benzoate + ATP + amino acid = benzoyl amino acid conjugate + AMP + diphosphate. |
| vanillate amino acid synthetase activity | Catalysis of the reaction: vanillate + ATP + amino acid = vanillate amino acid conjugate + AMP + diphosphate. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| benzoate metabolic process | The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid), a fungistatic compound widely used as a food preservative; it is conjugated to glycine in the liver and excreted as hippuric acid. |
| cellular response to hypoxia | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. |
| defense response | Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. |
| defense response to bacterium | Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. |
| detection of fungus | The series of events in which a stimulus from a fungus is received and converted into a molecular signal. |
| plant-type hypersensitive response | The rapid, localized death of plant cells in response to invasion by a pathogen. |
| positive regulation of plant-type hypersensitive response | Any process that activates or increases the frequency, rate or extent of the hypersensitive response in a plant. |
| regulation of systemic acquired resistance | Any process that modulates the frequency, rate or extent of systemic acquired resistance. |
| salicylic acid mediated signaling pathway | The series of molecular signals mediated by salicylic acid. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O22190 | GH3.3 | Indole-3-acetic acid-amido synthetase GH3.3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O81829 | GH3.5 | Indole-3-acetic acid-amido synthetase GH3.5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LSQ4 | GH3.6 | Indole-3-acetic acid-amido synthetase GH3.6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKPIFDINET | FEKQLKDLTS | NVKSIQDNLL | EEIITPNTKT | EYLQRFLIDR | FDKELFKKNV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PIVSYEDIKP | YLDRVVNGES | SDVISARTIT | GFLLSSGTSG | GAQKMMPWNN | KYLDNLTFIY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DLRMQVITKH | VKGVEEGKGM | MFLFTKQESM | TPSGLPARVA | TSSYFKSDYF | KNRPSNWYYS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YTSPDEVILC | PNNTESLYCH | LLCGLVQRDE | VVRTGSIFAS | VMVRAIEVLK | NSWEELCSNI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RSGHLSNWVT | DLGCQNSVSL | VLGGPRPELA | DTIEEICNQN | SWKGIVKRLW | PNTKYIETVV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TGSMGQYVPM | LNYYCNDLPL | VSTTYGSSET | TFGINLDPLC | KPEDVSYTFM | PNMSYFEFIP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| MDGGDKNDVV | DLEDVKLGCT | YEPVVTNFAG | LYRMRVGDIV | LVTGFYNNAP | QFKFVRRENV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VLSIDSDKTN | EEDLFKAVSQ | AKLVLESSGL | DLKDFTSYAD | TSTFPGHYVV | YLEVDTKEGE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EKETAQFELD | EEALSTCCLV | MEESLDNVYK | RCRFKDGSIG | PLEIRVVRQG | TFDSLMDFFI |
| 550 | 560 | 570 | |||
| SQGASTGQYK | TPRCIKSGKA | LQVLETCVVA | KFFSI |