Q9LSQ4
Gene name |
GH3.6 (DFL1, At5g54510, F24B18.13) |
Protein name |
Indole-3-acetic acid-amido synthetase GH3.6 |
Names |
Auxin-responsive GH3-like protein 6, AtGH3-6, Protein DWARF IN LIGHT 1, DFL-1 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G54510 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q9LSQ4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 7VKA | X-ray | 240 A | A/B | 1-612 | PDB |
| AF-Q9LSQ4-F1 | Predicted | AlphaFoldDB |
32 variants for Q9LSQ4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH07417930 | 18 | A>T | No | 1000Genomes | |
| tmp_5_22133496_G_C | 23 | N>K | No | 1000Genomes | |
| ENSVATH12762261 | 34 | N>K | No | 1000Genomes | |
| ENSVATH12762260 | 35 | A>P | No | 1000Genomes | |
| ENSVATH00733829 | 35 | A>V | No | 1000Genomes | |
| ENSVATH12762259 | 36 | D>E | No | 1000Genomes | |
| tmp_5_22133459_C_A | 36 | D>Y | No | 1000Genomes | |
| tmp_5_22133455_T_C | 37 | D>G | No | 1000Genomes | |
| tmp_5_22133316_T_G | 83 | Q>H | No | 1000Genomes | |
| tmp_5_22133314_G_A | 84 | P>L | No | 1000Genomes | |
| tmp_5_22133312_C_G | 85 | E>Q | No | 1000Genomes | |
| ENSVATH12762257 | 96 | Q>E | No | 1000Genomes | |
| tmp_5_22132796_C_G | 167 | G>A | No | 1000Genomes | |
| tmp_5_22132637_C_T | 220 | C>Y | No | 1000Genomes | |
| ENSVATH07417919 | 221 | Q>H | No | 1000Genomes | |
| ENSVATH07417918 | 222 | H>Y | No | 1000Genomes | |
| tmp_5_22132517_C_T | 260 | S>N | No | 1000Genomes | |
| tmp_5_22132514_G_A | 261 | S>F | No | 1000Genomes | |
| ENSVATH07417917 | 271 | A>V | No | 1000Genomes | |
| tmp_5_22132229_C_T | 356 | S>N | No | 1000Genomes | |
| tmp_5_22132154_G_T,C | 381 | T>N | No | 1000Genomes | |
| tmp_5_22132154_G_T,C | 381 | T>S | No | 1000Genomes | |
| ENSVATH07417910 | 504 | C>Y | No | 1000Genomes | |
| ENSVATH14632393 | 507 | G>C | No | 1000Genomes | |
| ENSVATH00733823 | 509 | T>M | No | 1000Genomes | |
| ENSVATH03428257 | 510 | P>S | No | 1000Genomes | |
| tmp_5_22131575_T_A | 529 | S>C | No | 1000Genomes | |
| tmp_5_22131413_T_C | 583 | I>V | No | 1000Genomes | |
| tmp_5_22131342_G_C | 606 | H>Q | No | 1000Genomes | |
| ENSVATH12762235 | 608 | Q>E | No | 1000Genomes | |
| tmp_5_22131336_T_A | 608 | Q>H | No | 1000Genomes | |
| ENSVATH03428256 | 613 | N>Q | No | 1000Genomes |
No associated diseases with Q9LSQ4
No regional properties for Q9LSQ4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9LSQ4 | |||
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| acid-amino acid ligase activity | Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. |
| indole-3-acetic acid amido synthetase activity | Catalysis of the reaction: indole-3-acetic acid + an amino acid = an indole-3-acetic acid amide conjugate. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| auxin homeostasis | A homeostatic process that maintains an endogenous steady-state concentration of primary auxin, or constant level of auxin in a biological system, by a number of biochemical processes including transport, biosynthesis, catabolism and conjugation. |
| auxin-activated signaling pathway | The series of molecular signals generated by the binding of the plant hormone auxin to a receptor, and ending with modulation of a downstream cellular process, e.g. transcription. |
| response to auxin | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus. |
| unidimensional cell growth | The process in which a cell irreversibly increases in size in one |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O81829 | GH3.5 | Indole-3-acetic acid-amido synthetase GH3.5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O22190 | GH3.3 | Indole-3-acetic acid-amido synthetase GH3.3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LYU4 | GH3.12 | 4-substituted benzoates-glutamate ligase GH3.12 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPEAPKIAAL | EVSDESLAEK | NKNKLQFIED | VTTNADDVQR | RVLEEILSRN | ADVEYLKRHG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LEGRTDRETF | KHIMPVVTYE | DIQPEINRIA | NGDKSQVLCS | NPISEFLTSS | GTSGGERKLM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PTIEEELDRR | SLLYSLLMPV | MDQFVPGLDK | GKGMYFLFIK | SESKTPGGLP | ARPVLTSYYK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SSHFKNRPYD | PYTNYTSPNQ | TILCSDSYQS | MYSQMLCGLC | QHKEVLRVGA | VFASGFIRAI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KFLEKHWPEL | ARDIRTGTLS | SEITDSSVRE | AVGEILKPDP | KLADFVESEC | RKTSWQGIIT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RLWPNTKYVD | VIVTGTMSQY | IPTLDYYSNG | LPLVCTMYAS | SECYFGVNLR | PLCKPSEVSY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TLIPNMAYFE | FLPVHRNSGV | TSSISLPKAL | TEKEQQELVD | LVDVKLGQEY | ELVVTTYAGL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YRYRVGDVLS | VAGFKNNAPQ | FSFICRKNVV | LSIDSDKTDE | VELQNAVKNA | VTHLVPFDAS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LSEYTSYADT | SSIPGHYVLF | WELCLNGNTP | IPPSVFEDCC | LTIEESLNSV | YRQGRVSDKS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| IGPLEIKMVE | SGTFDKLMDY | AISLGASINQ | YKTPRCVKFA | PIIELLNSRV | VDSYFSPKCP |
| 610 | |||||
| KWSPGHKQWG | SN |