O22190
Gene name |
GH3.3 (At2g23170, T20D16.20) |
Protein name |
Indole-3-acetic acid-amido synthetase GH3.3 |
Names |
Auxin-responsive GH3-like protein 3, AtGH3-3 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT2G23170 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O22190
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O22190-F1 | Predicted | AlphaFoldDB |
40 variants for O22190
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH14536404 | 5 | S>L | No | 1000Genomes | |
| ENSVATH13344741 | 9 | S>Y | No | 1000Genomes | |
| tmp_2_9866466_G_A | 13 | H>Y | No | 1000Genomes | |
| ENSVATH05563757 | 27 | E>D | No | 1000Genomes | |
| ENSVATH01872710 | 32 | N>H | No | 1000Genomes | |
| ENSVATH05563756 | 40 | V>M | No | 1000Genomes | |
| ENSVATH01872709 | 46 | S>C | No | 1000Genomes | |
| ENSVATH01872708 | 70 | T>N | No | 1000Genomes | |
| ENSVATH00243193 | 76 | I>T | No | 1000Genomes | |
| ENSVATH05563755 | 92 | R>Q | No | 1000Genomes | |
| ENSVATH13344714 | 151 | A>S | No | 1000Genomes | |
| tmp_2_9865417_C_T | 166 | G>R | No | 1000Genomes | |
| ENSVATH01872700 | 187 | N>Y | No | 1000Genomes | |
| ENSVATH13344713 | 255 | G>A | No | 1000Genomes | |
| tmp_2_9865122_G_A | 264 | P>L | No | 1000Genomes | |
| ENSVATH05563738 | 265 | A>T | No | 1000Genomes | |
| tmp_2_9865111_C_T | 268 | E>K | No | 1000Genomes | |
| tmp_2_9865089_G_T | 275 | T>N | No | 1000Genomes | |
| ENSVATH00243191 | 279 | Q>H | No | 1000Genomes | |
| tmp_2_9865078_G_T | 279 | Q>K | No | 1000Genomes | |
| tmp_2_9865018_T_G | 299 | I>L | No | 1000Genomes | |
| tmp_2_9864960_G_C | 318 | A>G | No | 1000Genomes | |
| tmp_2_9864949_G_C | 322 | P>A | No | 1000Genomes | |
| tmp_2_9864898_C_T | 339 | A>T | No | 1000Genomes | |
| ENSVATH13344708 | 365 | N>S | No | 1000Genomes | |
| ENSVATH05563736 | 380 | E>K | No | 1000Genomes | |
| ENSVATH00243190 | 382 | S>T | No | 1000Genomes | |
| tmp_2_9864757_C_G | 386 | E>Q | No | 1000Genomes | |
| tmp_2_9864561_C_T | 451 | S>N | No | 1000Genomes | |
| ENSVATH00243189 | 453 | V>I | No | 1000Genomes | |
| ENSVATH05563735 | 482 | H>R | No | 1000Genomes | |
| ENSVATH05563733 | 498 | P>S | No | 1000Genomes | |
| tmp_2_9864399_C_T | 505 | R>Q | No | 1000Genomes | |
| ENSVATH00243187 | 510 | M>L | No | 1000Genomes | |
| ENSVATH05563731 | 512 | E>D | No | 1000Genomes | |
| ENSVATH13344706 | 523 | V>I | No | 1000Genomes | |
| tmp_2_9864302_C_A | 537 | K>N | No | 1000Genomes | |
| ENSVATH14536396 | 585 | A>T | No | 1000Genomes | |
| ENSVATH13344705 | 593 | R>C | No | 1000Genomes | |
| ENSVATH05563729 | 595 | R>H | No | 1000Genomes |
No associated diseases with O22190
No regional properties for O22190
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for O22190 | |||
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| acid-amino acid ligase activity | Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. |
| indole-3-acetic acid amido synthetase activity | Catalysis of the reaction: indole-3-acetic acid + an amino acid = an indole-3-acetic acid amide conjugate. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| auxin homeostasis | A homeostatic process that maintains an endogenous steady-state concentration of primary auxin, or constant level of auxin in a biological system, by a number of biochemical processes including transport, biosynthesis, catabolism and conjugation. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9LYU4 | GH3.12 | 4-substituted benzoates-glutamate ligase GH3.12 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O81829 | GH3.5 | Indole-3-acetic acid-amido synthetase GH3.5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LSQ4 | GH3.6 | Indole-3-acetic acid-amido synthetase GH3.6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTVDSALRSP | MMHSPSTKDV | KALRFIEEMT | RNVDFVQKKV | IREILSRNSD | TEYLKRFGLK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GFTDRKTFKT | KVPVVIYDDL | KPEIQRIANG | DRSMILSSYP | ITEFLTSSGT | SAGERKLMPT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IDEDMDRRQL | LYSLLMPVMN | LYVPGLDKGK | ALYFLFVKTE | SKTPGGLPAR | PVLTSYYKSE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QFKRRPNDPY | NVYTSPNEAI | LCPDSSQSMY | TQMLCGLLMR | HEVLRLGAVF | ASGLLRAIGF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LQTNWKELAD | DISTGTLSSR | ISDPAIKESM | SKILTKPDQE | LADFITSVCG | QDNSWEGIIT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KIWPNTKYLD | VIVTGAMAQY | IPMLEYYSGG | LPMACTMYAS | SESYFGINLK | PMCKPSEVSY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TIMPNMAYFE | FLPHHEVPTE | KSELVELADV | EVGKEYELVI | TTYAGLNRYR | VGDILQVTGF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YNSAPQFKFV | RRKNVLLSIE | SDKTDEAELQ | SAVENASLLL | GEQGTRVIEY | TSYAETKTIP |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GHYVIYWELL | VKDQTNPPND | EVMARCCLEM | EESLNSVYRQ | SRVADKSIGP | LEIRVVKNGT |
| 550 | 560 | 570 | 580 | 590 | |
| FEELMDYAIS | RGASINQYKV | PRCVSFTPIM | ELLDSRVVST | HFSPALPHWS | PERRR |