O81829
Gene name |
GH3.5 (At4g27260, M4I22.70) |
Protein name |
Indole-3-acetic acid-amido synthetase GH3.5 |
Names |
Auxin-responsive GH3-like protein 5, AtGH3-5 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G27260 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for O81829
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 5KOD | X-ray | 220 A | A/B/C/D | 1-612 | PDB |
| AF-O81829-F1 | Predicted | AlphaFoldDB |
21 variants for O81829
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_4_13653708_C_G | 2 | P>R | No | 1000Genomes | |
| tmp_4_13653809_G_T | 36 | D>Y | No | 1000Genomes | |
| tmp_4_13653849_G_T,A | 49 | R>H | No | 1000Genomes | |
| tmp_4_13653849_G_T,A | 49 | R>L | No | 1000Genomes | |
| tmp_4_13653974_A_G | 91 | N>D | No | 1000Genomes | |
| ENSVATH06784104 | 182 | S>P | No | 1000Genomes | |
| ENSVATH12256770 | 218 | G>A | No | 1000Genomes | |
| tmp_4_13654717_C_G | 252 | R>G | No | 1000Genomes | |
| ENSVATH06784106 | 280 | P>S | No | 1000Genomes | |
| tmp_4_13654861_A_T | 300 | T>S | No | 1000Genomes | |
| ENSVATH14301624 | 353 | C>Y | No | 1000Genomes | |
| ENSVATH14301635 | 366 | M>R | No | 1000Genomes | |
| tmp_4_13655134_A_T | 391 | T>S | No | 1000Genomes | |
| tmp_4_13655364_A_T | 437 | K>N | No | 1000Genomes | |
| ENSVATH14301636 | 477 | F>L | No | 1000Genomes | |
| tmp_4_13655563_T_C | 504 | C>R | No | 1000Genomes | |
| ENSVATH02930254 | 508 | N>I | No | 1000Genomes | |
| tmp_4_13655579_C_T | 509 | T>I | No | 1000Genomes | |
| tmp_4_13655596_G_A | 515 | V>I | No | 1000Genomes | |
| ENSVATH06784113 | 592 | D>G | No | 1000Genomes | |
| ENSVATH06784114 | 611 | S>R | No | 1000Genomes |
No associated diseases with O81829
No regional properties for O81829
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for O81829 | |||
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| acid-amino acid ligase activity | Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. |
| indole-3-acetic acid amido synthetase activity | Catalysis of the reaction: indole-3-acetic acid + an amino acid = an indole-3-acetic acid amide conjugate. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| auxin homeostasis | A homeostatic process that maintains an endogenous steady-state concentration of primary auxin, or constant level of auxin in a biological system, by a number of biochemical processes including transport, biosynthesis, catabolism and conjugation. |
| camalexin biosynthetic process | The chemical reactions and pathways resulting in the formation of camalexin, an indole phytoalexin. |
| positive regulation of camalexin biosynthetic process | Any process that activates or increases the frequency, rate or extent of camalexin biosynthetic process. |
| response to auxin | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9LSQ4 | GH3.6 | Indole-3-acetic acid-amido synthetase GH3.6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O22190 | GH3.3 | Indole-3-acetic acid-amido synthetase GH3.3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LYU4 | GH3.12 | 4-substituted benzoates-glutamate ligase GH3.12 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPEAPKKESL | EVFDLTLDQK | NKQKLQLIEE | LTSNADQVQR | QVLEEILTRN | ADVEYLRRHD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LNGRTDRETF | KNIMPVITYE | DIEPEINRIA | NGDKSPILSS | KPISEFLTSS | GTSGGERKLM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PTIEEELDRR | SLLYSLLMPV | MSQFVPGLEN | GKGMYFLFIK | SESKTPGGLP | ARPVLTSYYK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SSHFKERPYD | PYTNYTSPNE | TILCSDSYQS | MYSQMLCGLC | QHQEVLRVGA | VFASGFIRAI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KFLEKHWIEL | VRDIRTGTLS | SLITDPSVRE | AVAKILKPSP | KLADFVEFEC | KKSSWQGIIT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RLWPNTKYVD | VIVTGTMSQY | IPTLDYYSNG | LPLVCTMYAS | SECYFGVNLR | PLCKPSEVSY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TLIPSMAYFE | FLPVHRNNGV | TNSINLPKAL | TEKEQQELVD | LVDVKLGQEY | ELVVTTYAGL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| CRYRVGDLLR | VTGFKNKAPQ | FSFICRKNVV | LSIDSDKTDE | VELQNAVKNA | VTHLVPFDAS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LSEYTSYADT | SSIPGHYVLF | WELCLDGNTP | IPPSVFEDCC | LAVEESFNTV | YRQGRVSDKS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| IGPLEIKIVE | PGTFDKLMDY | AISLGASINQ | YKTPRCVKFA | PIIELLNSRV | VDSYFSPKCP |
| 610 | |||||
| KWVPGHKQWG | SN |