Q9LVC8
Gene name |
COQ5 |
Protein name |
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial |
Names |
Ubiquinone biosynthesis methyltransferase COQ5 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G57300 |
EC number |
2.1.1.201: Methyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9LVC8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9LVC8-F1 | Predicted | AlphaFoldDB |
24 variants for Q9LVC8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_5_23210598_G_A | 5 | S>L | No | 1000Genomes | |
| ENSVATH07439227 | 12 | S>T | No | 1000Genomes | |
| ENSVATH07439226 | 17 | Q>H | No | 1000Genomes | |
| ENSVATH00739049 | 28 | A>V | No | 1000Genomes | |
| ENSVATH14637361 | 47 | N>T | No | 1000Genomes | |
| tmp_5_23210142_C_T | 84 | G>E | No | 1000Genomes | |
| tmp_5_23209968_C_T | 104 | A>T | No | 1000Genomes | |
| ENSVATH12825347 | 107 | S>R | No | 1000Genomes | |
| ENSVATH07439214 | 119 | A>V | No | 1000Genomes | |
| ENSVATH07439213 | 137 | N>D | No | 1000Genomes | |
| tmp_5_23209842_T_C | 146 | R>G | No | 1000Genomes | |
| ENSVATH14637359 | 151 | N>D | No | 1000Genomes | |
| ENSVATH07439210 | 155 | V>I | No | 1000Genomes | |
| ENSVATH07439209 | 165 | S>I | No | 1000Genomes | |
| ENSVATH00739045 | 187 | E>K | No | 1000Genomes | |
| tmp_5_23209585_C_T | 195 | R>K | No | 1000Genomes | |
| ENSVATH03443778 | 197 | L>I | No | 1000Genomes | |
| ENSVATH07439202 | 216 | F>L | No | 1000Genomes | |
| tmp_5_23209304_C_A | 226 | Q>H | No | 1000Genomes | |
| ENSVATH00739043 | 250 | R>C | No | 1000Genomes | |
| ENSVATH14637355 | 259 | A>S | No | 1000Genomes | |
| ENSVATH12825302 | 269 | K>E | No | 1000Genomes | |
| ENSVATH12825301 | 269 | K>M | No | 1000Genomes | |
| tmp_5_23208745_A_G | 276 | V>A | No | 1000Genomes |
No associated diseases with Q9LVC8
2 regional properties for Q9LVC8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | UbiE/COQ5 methyltransferase, conserved site | 56 - 71 | IPR023576-1 |
| conserved_site | UbiE/COQ5 methyltransferase, conserved site | 195 - 209 | IPR023576-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.201 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| extrinsic component of mitochondrial inner membrane | The component of mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| 2-nonaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity | Catalysis of the reaction: 2-nonaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine. |
| 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity | Catalysis of the reaction: 2-octaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine. |
| methyltransferase activity | Catalysis of the transfer of a methyl group to an acceptor molecule. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| methylation | The process in which a methyl group is covalently attached to a molecule. |
| ubiquinone biosynthetic process | The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q0P5A2 | COQ5 | 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial | Bos taurus (Bovine) | PR |
| Q5ZLL5 | COQ5 | 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial | Gallus gallus (Chicken) | PR |
| Q4G064 | Coq5 | 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial | Rattus norvegicus (Rat) | PR |
| P34666 | coq-5 | 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALRSVSRRL | GSRILNQRSF | VASLHSHATS | FGFQEVKEEE | KSKLVGNVFT | NVASSYDIMN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DVMSGGLHRL | WKERLVGKLS | PFAGMKHLDV | AGGTGDVAFR | IYDAVYSVKR | RALQKVDEAS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LEETQIYVCD | INPNMLNVGK | QRAAERGLRD | NKSLVWVEGD | AEALSFDDNS | MDGYTIAFGI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RNVTHIEKAL | AEAYRVLKRG | GRFLCLELSH | VEIPVFKNLY | DLYSFQVIPN | LGELIAGDRE |
| 250 | 260 | 270 | 280 | ||
| SYQYLVESVR | RFPPQERFAS | MIADAGFEKV | EYENLVGGVV | AIHSAIKL |