Q4G064
Gene name |
Coq5 |
Protein name |
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial |
Names |
Ubiquinone biosynthesis methyltransferase COQ5 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:304542 |
EC number |
2.1.1.201: Methyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q4G064
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q4G064-F1 | Predicted | AlphaFoldDB |
No variants for Q4G064
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q4G064 | |||||
No associated diseases with Q4G064
2 regional properties for Q4G064
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | UbiE/COQ5 methyltransferase, conserved site | 79 - 94 | IPR023576-1 |
| conserved_site | UbiE/COQ5 methyltransferase, conserved site | 234 - 248 | IPR023576-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.201 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| extrinsic component of mitochondrial inner membrane | The component of mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. |
| mitochondrial inner membrane | The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. |
| mitochondrial matrix | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
| ubiquinone biosynthesis complex | The cytosolic ubiquinone biosynthesis complex is composed of enzymes and accessory factors of the ubiquinone biosynthesis pathway and enables synthesis of the extremely hydrophobic molecule ubiquinone. In E. coli, the complex is composed of seven proteins: UbiE, F, G, H, I, J and K. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity | Catalysis of the reaction: 2-octaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine. |
| methyltransferase activity | Catalysis of the transfer of a methyl group to an acceptor molecule. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| methylation | The process in which a methyl group is covalently attached to a molecule. |
| ubiquinone biosynthetic process | The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q0P5A2 | COQ5 | 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial | Bos taurus (Bovine) | PR |
| Q5ZLL5 | COQ5 | 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial | Gallus gallus (Chicken) | PR |
| P34666 | coq-5 | 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial | Caenorhabditis elegans | PR |
| Q9LVC8 | COQ5 | 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAPRSCVLW | SYCGHGWSRL | AGDCRLPGFR | RSWLGATLSA | RSLSQEKRAA | ETHFGFETVS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EKEKGGKVYQ | VFQSVARKYD | LMNDMMSLGI | HRAWKDLLIR | KMHPLPGTQL | LDVAGGTGDI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AFRFLSYVQT | QHERKQRRQL | RTRQNLSWEE | IARKYQSKED | PLGGSLVMVC | DINREMLKVG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KQKALARGHT | AGLAWVLGDA | EELPFDDDRF | DVYTIAFGIR | NVTHIDRALQ | EAHRVLKPGG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RFLCLEFSQV | NDPLISRLYD | LYSFQVIPVI | GEVIAGDWKS | YQYLVESIRK | FPNQEEFKDM |
| 310 | 320 | ||||
| IEDAGFQKVT | YESLTSGIVA | IHSGFKL |