P34666

PR
Gene name
coq-5
Protein name
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
Names
Ubiquinone biosynthesis methyltransferase COQ5
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_ZK652.9
EC number
2.1.1.201: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-85 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P34666

Entry ID Method Resolution Chain Position Source
AF-P34666-F1 Predicted AlphaFoldDB

No variants for P34666

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P34666

No associated diseases with P34666

2 regional properties for P34666

Type Name Position InterPro Accession
conserved_site UbiE/COQ5 methyltransferase, conserved site 68 - 83 IPR023576-1
conserved_site UbiE/COQ5 methyltransferase, conserved site 191 - 205 IPR023576-2

Functions

Description
EC Number 2.1.1.201 Methyltransferases
Subcellular Localization
  • Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extrinsic component of mitochondrial inner membrane The component of mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.

2 GO annotations of molecular function

Name Definition
2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity Catalysis of the reaction: 2-octaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine.
methyltransferase activity Catalysis of the transfer of a methyl group to an acceptor molecule.

2 GO annotations of biological process

Name Definition
methylation The process in which a methyl group is covalently attached to a molecule.
ubiquinone biosynthetic process The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q0P5A2 COQ5 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial Bos taurus (Bovine) PR
Q5ZLL5 COQ5 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial Gallus gallus (Chicken) PR
Q4G064 Coq5 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial Rattus norvegicus (Rat) PR
Q9LVC8 COQ5 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MKGATNLFKS MRKPTNVGNF RQFSVNQVNS DNKRSEPGKK THFGFTDVDE AEKEQKVHHV
70 80 90 100 110 120
FANVAKKYDL MNDAMSMGVH RLWKDYYVGG LQVPYNAKCL DMAGGTGDIA FRILRHSPTA
130 140 150 160 170 180
KVTVSDINQP MLDVGKKRAE KERDIQPSRA EWVCANAEQM PFESNTYDLF TMSFGIRNCT
190 200 210 220 230 240
HPEKVVREAF RVLKPGGQLA ILEFSEVNSA LKPIYDAYSF NVIPVLGEIL ASDRASYQYL
250 260 270 280
VESIRKFPNQ DEFARIIREE GFSNVRYENL TFGVCSIHKG MKPRK