Q0P5A2

PR
Gene name
COQ5
Protein name
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
Names
Ubiquinone biosynthesis methyltransferase COQ5
Species
Bos taurus (Bovine)
KEGG Pathway
bta:533208
EC number
2.1.1.201: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-94 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q0P5A2

Entry ID Method Resolution Chain Position Source
AF-Q0P5A2-F1 Predicted AlphaFoldDB

51 variants for Q0P5A2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs481899177 6 S>R No EVA
rs444736734 7 W>* No EVA
rs463345837 7 W>R No EVA
rs471099088 8 A>S No EVA
rs452636712 9 L>Q No EVA
rs473588255 11 S>G No EVA
rs436462889 12 F>S No EVA
rs454959487 12 F>V No EVA
rs469384257 13 C>G No EVA
rs457311165 15 C>F No EVA
rs133436703 15 C>W No EVA
rs432284529 16 G>V No EVA
rs446714254 17 W>C No EVA
rs465258601 17 W>G No EVA
rs467564993 19 R>G No EVA
rs481956139 21 V>G No EVA
rs463228986 22 S>W No EVA
rs459093820 26 L>I No EVA
rs440653888 28 G>R No EVA
rs455097001 29 L>H No EVA
rs473617668 29 L>V No EVA
rs457372403 31 S>R No EVA
rs432347868 31 S>T No EVA
rs471750341 32 S>C No EVA
rs467581543 33 S>L No EVA
rs434660228 33 S>P No EVA
rs434660228 33 S>T No EVA
rs444858857 37 P>H No EVA
rs480132967 41 R>L No EVA
rs443006870 42 L>F No EVA
rs475951402 47 K>E No EVA
rs463860725 48 E>G No EVA
rs438887355 49 A>G No EVA
rs453267234 51 E>G No EVA
rs471822356 51 E>Q No EVA
rs453267234 51 E>V No EVA
rs434722416 52 T>A No EVA
rs455504821 66 G>R No EVA
rs465221231 94 W>* No EVA
rs460278628 113 V>G No EVA
rs472450032 113 V>I No EVA
rs441748527 117 T>A No EVA
rs435791511 121 A>S No EVA
rs468567660 129 Q>P No EVA
rs450115152 130 A>T No EVA
rs723905992 135 K>T No EVA
rs43104626 191 A>D No EVA
rs454166633 322 H>Q No EVA
rs446054389 325 F>C No EVA
rs435696076 328 Y>* No EVA
rs468510367 331 R>E No EVA

No associated diseases with Q0P5A2

2 regional properties for Q0P5A2

Type Name Position InterPro Accession
conserved_site UbiE/COQ5 methyltransferase, conserved site 79 - 94 IPR023576-1
conserved_site UbiE/COQ5 methyltransferase, conserved site 234 - 248 IPR023576-2

Functions

Description
EC Number 2.1.1.201 Methyltransferases
Subcellular Localization
  • Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
extrinsic component of mitochondrial inner membrane The component of mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
ubiquinone biosynthesis complex The cytosolic ubiquinone biosynthesis complex is composed of enzymes and accessory factors of the ubiquinone biosynthesis pathway and enables synthesis of the extremely hydrophobic molecule ubiquinone. In E. coli, the complex is composed of seven proteins: UbiE, F, G, H, I, J and K.

2 GO annotations of molecular function

Name Definition
2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity Catalysis of the reaction: 2-octaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine.
methyltransferase activity Catalysis of the transfer of a methyl group to an acceptor molecule.

2 GO annotations of biological process

Name Definition
methylation The process in which a methyl group is covalently attached to a molecule.
ubiquinone biosynthetic process The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5ZLL5 COQ5 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial Gallus gallus (Chicken) PR
Q4G064 Coq5 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial Rattus norvegicus (Rat) PR
P34666 coq-5 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial Caenorhabditis elegans PR
Q9LVC8 COQ5 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAAPRSWALW SFCGCGWSRA VSGCRLPGLR SSSPRGPLGA RLLSQEKEAT ETHFGFETVS
70 80 90 100 110 120
EEEKGGKVYQ VFESVAKKYD VMNDMMSLGI HRVWKDLLLW KMRPFPGTQL LDVAGGTGDI
130 140 150 160 170 180
AFRFLNYVQA QHQRKQKRQL RAQQNLSWEE IARKYQNEED SLGGSHVMVC DINKEMLKIG
190 200 210 220 230 240
KQKARAQGYK AGLAWILGDA EELPFDDNKF DVYTIAFGIR NVTHIDQALQ EAHRVLKPGG
250 260 270 280 290 300
RFLCLEFSQV NNPLLSRLYD VYSFQVIPVL GEVIAGDWKS YQYLVESIRQ FPSQEEFKEM
310 320
IEDAGFQKVT YENLTSGIVA IHSGFKLYLR