Q9LK25

PR
Gene name
PHB4 (At3g27280, K17E12.10)
Protein name
Prohibitin-4, mitochondrial
Names
Atphb4
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G27280
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

164-255 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9LK25

Entry ID Method Resolution Chain Position Source
AF-Q9LK25-F1 Predicted AlphaFoldDB

18 variants for Q9LK25

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH02218105 2 G>A No 1000Genomes
ENSVATH00354926 6 V>A No 1000Genomes
tmp_3_10076919_G_C 6 V>L No 1000Genomes
tmp_3_10076946_G_T 15 A>S No 1000Genomes
ENSVATH05934615 62 L>M No 1000Genomes
tmp_3_10077186_C_T 95 L>F No 1000Genomes
ENSVATH05934623 138 N>T No 1000Genomes
tmp_3_10077671_C_T 154 L>F No 1000Genomes
ENSVATH14030717 157 D>A No 1000Genomes
ENSVATH00354934 157 D>E No 1000Genomes
ENSVATH05934624 161 K>M No 1000Genomes
tmp_3_10077752_G_A 181 G>S No 1000Genomes
ENSVATH14030718 182 A>G No 1000Genomes
tmp_3_10077829_G_A 206 M>I No 1000Genomes
ENSVATH14030719 209 D>V No 1000Genomes
tmp_3_10077923_A_T 238 M>L No 1000Genomes
ENSVATH05934628 245 R>M No 1000Genomes
tmp_3_10077987_C_T 259 S>F No 1000Genomes

No associated diseases with Q9LK25

3 regional properties for Q9LK25

Type Name Position InterPro Accession
domain AsnC-type HTH domain 12 - 73 IPR000485
domain ArsR-like helix-turn-helix domain 13 - 60 IPR011991
domain Transcription regulator AsnC/Lrp, ligand binding domain 80 - 147 IPR019887

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion inner membrane ; Single-pass type II membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrial respiratory chain complex I A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
plant-type cell wall A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances.
plant-type vacuole A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
mitochondrion organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3T165 PHB1 Prohibitin 1 Bos taurus (Bovine) PR
P84173 PHB1 Prohibitin 1 Gallus gallus (Chicken) PR
P35232 PHB1 Prohibitin 1 Homo sapiens (Human) PR
Q9LY99 PHB5 Prohibitin-5, mitochondrial Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MGSQQVAISF LTNLAKAAFG LGVAATALNS SLYTVDGGER AVLFDRFRGV LDQTVGEGTH
70 80 90 100 110 120
FLIPYLQTPH IYDIRTKPHT FSSKSGTKDL QMVNLTLRVL FRPEVSRLPY IFQTLGLEYD
130 140 150 160 170 180
EKVLPSIGNE VLKAVVANFN ADQLLTERPQ VSALVRDALI KRAREFNIEL DDIAITHLSY
190 200 210 220 230 240
GAEFSRAVEA KQVAQQEAER SKFVVMKADQ ERRAAVIRAE GESEAAQLIS DATAKAGMGL
250 260 270
IELRRIEASR EVAATLARSP NVAYLPGGQS MLFNLNPGR