Q9JJB9
Gene name |
Tmem183 (Tmem183a, MNCb-2755) |
Protein name |
Transmembrane protein 183 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:57439 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9JJB9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9JJB9-F1 | Predicted | AlphaFoldDB |
19 variants for Q9JJB9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3390677344 | 89 | E>D | No | EVA | |
| rs3390693100 | 96 | S>C | No | EVA | |
| rs3390508134 | 97 | S>C | No | EVA | |
| rs260042695 | 112 | V>I | No | EVA | |
| rs3388501011 | 143 | Y>C | No | EVA | |
| rs3390583720 | 151 | N>H | No | EVA | |
| rs3388503097 | 225 | E>G | No | EVA | |
| rs221032001 | 268 | S>N | No | EVA | |
| rs3388503119 | 269 | K>T | No | EVA | |
| rs251024326 | 270 | C>R | No | EVA | |
| rs251024326 | 270 | C>S | No | EVA | |
| rs3390657526 | 292 | C>S | No | EVA | |
| rs3390611638 | 294 | L>V | No | EVA | |
| rs3388499788 | 295 | Q>H | No | EVA | |
| rs1134726630 | 305 | P>T | No | EVA | |
| rs1133881146 | 308 | M>I | No | EVA | |
| rs1133309955 | 310 | M>I | No | EVA | |
| rs3390632362 | 329 | R>MPHV* | No | EVA | |
| rs3388499657 | 347 | Q>E | No | EVA |
No associated diseases with Q9JJB9
No regional properties for Q9JJB9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9JJB9 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| SCF ubiquitin ligase complex | A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of protein stability | Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5EA86 | TMEM183 | Transmembrane protein 183 | Bos taurus (Bovine) | PR |
| Q8IXX5 | TMEM183A | Transmembrane protein 183A | Homo sapiens (Human) | PR |
| Q1AE95 | TMEM183BP | Putative transmembrane protein 183BP | Homo sapiens (Human) | PR |
| Q68FS7 | Tmem183 | Transmembrane protein 183 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MARGSGQLGG | PHRDTVTMPK | RGKRLKFRAH | DACSGRVTVA | DYANSDPAVV | RSGRVKKAVA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NAIQQEVKSL | CGLEASQVPA | EEALSGVGEP | CDILDSSDEM | DAQEESTQER | SVSRKKKSKR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HKEDPDGTGE | EYPMDIWLLL | ASYIRPEDIV | NFSLICKNAW | TVTCTAAFWT | RLYRRHYTLD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ASLPLRLRPE | SMEKLRCLRA | CVIRSLYHMY | EPFAARISKN | PAIPESTPST | LKNSKCLLFW |
| 250 | 260 | 270 | 280 | 290 | 300 |
| CRKIVGNRQE | PMWEFNFKFK | KQSPRLKSKC | MERLQPPIQY | QDVHTNPDQD | CCLLQVTTLN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FIFIPIVMGM | IFTLFTINVS | TDMRHHRVRL | VFQDSPVRGG | QNLRSEQGVQ | VVLDPVHSVR |
| 370 | |||||
| LFDWWHPQYP | FSLRA |