Q5EA86
Gene name |
TMEM183 |
Protein name |
Transmembrane protein 183 |
Names |
|
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:534797 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5EA86
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5EA86-F1 | Predicted | AlphaFoldDB |
76 variants for Q5EA86
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs475056980 | 2 | A>P | No | EVA | |
| rs477735206 | 5 | P>A | No | EVA | |
| rs483029273 | 7 | P>T | No | EVA | |
| rs468664560 | 8 | L>Q | No | EVA | |
| rs436215830 | 9 | T>P | No | EVA | |
| rs466918337 | 10 | R>P | No | EVA | |
| rs475415790 | 12 | R>P | No | EVA | |
| rs474494847 | 14 | D>H | No | EVA | |
| rs440592485 | 15 | T>P | No | EVA | |
| rs471174067 | 16 | V>A | No | EVA | |
| rs463217354 | 18 | M>I | No | EVA | |
| rs439903645 | 18 | M>V | No | EVA | |
| rs483138580 | 19 | P>A | No | EVA | |
| rs462273963 | 20 | K>N | No | EVA | |
| rs442030219 | 20 | K>T | No | EVA | |
| rs479081000 | 21 | R>K | No | EVA | |
| rs466744581 | 22 | G>R | No | EVA | |
| rs477197399 | 23 | K>E | No | EVA | |
| rs445897239 | 25 | L>H | No | EVA | |
| rs454355632 | 31 | D>A | No | EVA | |
| rs433671093 | 36 | R>S | No | EVA | |
| rs455394298 | 69 | S>F | No | EVA | |
| rs441792342 | 69 | S>P | No | EVA | |
| rs472343311 | 71 | C>F | No | EVA | |
| rs441101689 | 72 | G>C | No | EVA | |
| rs457918728 | 73 | L>F | No | EVA | |
| rs443187905 | 75 | A>G | No | EVA | |
| rs477888982 | 75 | A>T | No | EVA | |
| rs443187905 | 75 | A>V | No | EVA | |
| rs463478522 | 77 | Q>P | No | EVA | |
| rs448965607 | 78 | V>G | No | EVA | |
| rs466377718 | 80 | A>P | No | EVA | |
| rs480025150 | 81 | V>G | No | EVA | |
| rs445574982 | 83 | A>G | No | EVA | |
| rs465617311 | 88 | G>C | No | EVA | |
| rs457148973 | 90 | P>A | No | EVA | |
| rs467574365 | 91 | C>R | No | EVA | |
| rs436467734 | 91 | C>S | No | EVA | |
| rs472431858 | 92 | D>E | No | EVA | |
| rs453241179 | 92 | D>V | No | EVA | |
| rs525014435 | 95 | D>N | No | EVA | |
| rs471657835 | 96 | S>I | No | EVA | |
| rs471657835 | 96 | S>N | No | EVA | |
| rs451621844 | 96 | S>R | No | EVA | |
| rs463367305 | 97 | S>I | No | EVA | |
| rs463367305 | 97 | S>N | No | EVA | |
| rs443518103 | 97 | S>R | No | EVA | |
| rs480172707 | 97 | S>R | No | EVA | |
| rs459377804 | 99 | E>G | No | EVA | |
| rs445377829 | 103 | Q>P | No | EVA | |
| rs465708743 | 107 | I>T | No | EVA | |
| rs482604970 | 109 | E>Q | No | EVA | |
| rs451060351 | 112 | I>T | No | EVA | |
| rs467611363 | 115 | K>* | No | EVA | |
| rs436302558 | 117 | K>T | No | EVA | |
| rs453329358 | 119 | K>Q | No | EVA | |
| rs435128707 | 153 | F>C | No | EVA | |
| rs477131351 | 233 | K>N | No | EVA | |
| rs455622136 | 237 | C>F | No | EVA | |
| rs472229855 | 237 | C>W | No | EVA | |
| rs455622136 | 237 | C>Y | No | EVA | |
| rs457860854 | 239 | L>R | No | EVA | |
| rs443279101 | 242 | C>F | No | EVA | |
| rs471515480 | 242 | C>G | No | EVA | |
| rs463932657 | 254 | W>C | No | EVA | |
| rs480847877 | 255 | E>K | No | EVA | |
| rs449541957 | 262 | K>T | No | EVA | |
| rs471353489 | 265 | P>T | No | EVA | |
| rs457011824 | 272 | M>I | No | EVA | |
| rs443343561 | 272 | M>R | No | EVA | |
| rs474447492 | 283 | D>E | No | EVA | |
| rs442990380 | 285 | H>Y | No | EVA | |
| rs459749331 | 287 | N>K | No | EVA | |
| rs479931715 | 301 | N>H | No | EVA | |
| rs439019405 | 312 | I>M | No | EVA | |
| rs458777917 | 314 | T>P | No | EVA |
No associated diseases with Q5EA86
1 regional properties for Q5EA86
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Phosphoribosyltransferase domain | 7 - 149 | IPR000836 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| SCF ubiquitin ligase complex | A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of protein stability | Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8IXX5 | TMEM183A | Transmembrane protein 183A | Homo sapiens (Human) | PR |
| Q1AE95 | TMEM183BP | Putative transmembrane protein 183BP | Homo sapiens (Human) | PR |
| Q9JJB9 | Tmem183 | Transmembrane protein 183 | Mus musculus (Mouse) | PR |
| Q68FS7 | Tmem183 | Transmembrane protein 183 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MARGPGPLTR | PRPDTVAMPK | RGKRLKFRAQ | DACSGRVTVA | DYANSDPAVV | RSGRVKKAVA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NAVQQEVKSL | CGLEASQVPA | VEALSGAGEP | CDIIDSSGET | DAQEESIHER | TISRKKKSKR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HREDLNGTGG | EEYPMDIWLL | LASYIRPEDI | VNFSLICKNA | WTVTCTAAFW | TRLYRRHYTL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DASLPLRLRP | ESMEKLHCLR | ACVIRSLYHM | YEPFAARISK | NPAIPESTPS | TLKNSKCLLF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| WCRKIVGNRQ | EPMWEFNFKF | KKQSPRLKSK | CMGGLQPPIQ | YEDVHTNPDQ | DCCLLQVTTL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NFIFIPIVMG | MIFTLFTISV | STDMRHHRVR | LVFQDYPVHG | GQKLRSEQGV | QVILDPVHSV |
| 370 | |||||
| RLFDWWHPQY | PFSLRA |