Q1AE95

PR
Gene name
TMEM183BP
Protein name
Putative transmembrane protein 183BP
Names
Transmembrane protein 183B pseudogene
Species
Homo sapiens (Human)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-156 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q1AE95

Entry ID Method Resolution Chain Position Source
AF-Q1AE95-F1 Predicted AlphaFoldDB

1 variants for Q1AE95

Variant ID(s) Position Change Description Diseaes Association Provenance
rs7630407
VAR_030867
 193 M>V No UniProt
dbSNP

No associated diseases with Q1AE95

2 regional properties for Q1AE95

Type Name Position InterPro Accession
binding_site Cytochrome c oxidase, subunit I, copper-binding site 275 - 329 IPR023615
domain Cytochrome c oxidase-like, subunit I domain 38 - 556 IPR023616

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
SCF ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
regulation of protein stability Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5EA86 TMEM183 Transmembrane protein 183 Bos taurus (Bovine) PR
Q8IXX5 TMEM183A Transmembrane protein 183A Homo sapiens (Human) PR
Q9JJB9 Tmem183 Transmembrane protein 183 Mus musculus (Mouse) PR
Q68FS7 Tmem183 Transmembrane protein 183 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MARGPGPLGR PRPDTVAMPK RGKRLKFRAH DACSGRVTVA DYADSDLAVV RSGRVKKAVA
70 80 90 100 110 120
NAVRQEVKSL CGLEASQVPA EEALSGAGEP YDIIDSSDEM DAQEENIHER TVSRKKKSKR
130 140 150 160 170 180
HKEELDGAGG EEYPMDIWLL LASYIRPEDI VNFSLICKNA WTVTCTAAFW TRLYRRHYTL
190 200 210 220 230 240
DASLPLRLRP ESMEKLHCLR ACVIRSLYHM YEPFAARISK NPAIPESTPS TLKNSKCLLF
250 260 270 280 290 300
WCRKIVGNRQ EPMWEFNFKF KKQSPRLKSK CTGGLQPPVQ YEDVHTNPDQ DCCLLQVTTL
310 320 330 340 350 360
NFIFIPIVMG MIFTLFTINV STDMRHHRVR LVFQDSPVHG GRKLRSEQGV QVILDPVHSV
370
RLFDWWHPQY PFSLRA