Q68FS7
Gene name |
Tmem183 |
Protein name |
Transmembrane protein 183 |
Names |
|
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:289034 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q68FS7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q68FS7-F1 | Predicted | AlphaFoldDB |
1 variants for Q68FS7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs198077662 | 4 | G>V | No | EVA |
No associated diseases with Q68FS7
No regional properties for Q68FS7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q68FS7 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| SCF ubiquitin ligase complex | A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of protein stability | Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5EA86 | TMEM183 | Transmembrane protein 183 | Bos taurus (Bovine) | PR |
| Q8IXX5 | TMEM183A | Transmembrane protein 183A | Homo sapiens (Human) | PR |
| Q1AE95 | TMEM183BP | Putative transmembrane protein 183BP | Homo sapiens (Human) | PR |
| Q9JJB9 | Tmem183 | Transmembrane protein 183 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MARGPGQLSG | PRPDTVTMPK | RGKRLKFRAH | DACSGRVTVA | DYANSDPAVV | RSGRVKKAVA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NAVQQEVKSL | CGLEASQVPA | EEALSGVGEP | SDILDSSDEM | DAQEESTQER | SVSRKKKSKR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HKEDLDGAGG | EEYPMDIWLL | LASYIRPEDI | VNFSLICKNA | WTVTCTAAFW | TRLYRRHYTL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DASLPLRLRP | ESMEKLRCLR | ACVIRSLYHM | YEPFAARISK | NPAIPESTPS | TLKNSKCLLF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| WCRKIVGNRQ | EPMWEFNFKF | KKQSPRLKSK | CMERLQPPIQ | YQDVHTNPDQ | DCCLLQVTTL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NFIFIPIVMG | MIFTLFTINV | STDMRHHRVR | LVFQDSPVRG | GQHLRSEQGV | QVVLDPVHSV |
| 370 | |||||
| RLFDWWHPQY | PFSLRA |