AiPD: Autoinhibited Protein Database

Q9H825

Gene name	METTL8
Protein name	tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial
Names	Methyltransferase-like protein 8, mRNA N(3)-methylcytidine methyltransferase METTL8
Species	Homo sapiens (Human)
KEGG Pathway	hsa:79828
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

29-192 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

29-192 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q9H825

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9H825-F1	Predicted				AlphaFoldDB

239 variants for Q9H825

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA349582778 rs1244685269	2	N>S		No	ClinGen TOPMed
rs1274214311 CA349582705	3	M>I		No	ClinGen TOPMed
rs993961314 CA60778446	4	I>V		No	ClinGen TOPMed
rs555507350 CA1964508	9	I>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1433660509 CA349582512	10	S>P		No	ClinGen gnomAD
rs1179070244 CA349582500	10	S>Y		No	ClinGen TOPMed
TCGA novel	11	C>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1291663453 CA349582484	11	C>Y		No	ClinGen TOPMed gnomAD
CA349582426 rs1421996953	14	L>P		No	ClinGen TOPMed
CA349582361 rs1237532851	16	K>N		No	ClinGen TOPMed gnomAD
rs1476035883 CA349582347	17	V>E		No	ClinGen TOPMed
rs1458969977 CA349582315	19	H>N		No	ClinGen gnomAD
CA349582288 rs1258472192	20	R>G		No	ClinGen gnomAD
rs536965356 CA60778406	21	Y>C		No	ClinGen 1000Genomes
rs1344610770 CA349582247	22	Q>*		No	ClinGen gnomAD
rs1273114673 CA349582230	22	Q>R		No	ClinGen gnomAD
rs569917058 CA1964507	23	S>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1372341203 CA349582122	24	G>V		No	ClinGen TOPMed gnomAD
CA349582057 rs1445016838	26	H>P		No	ClinGen gnomAD
CA349582053 rs1445016838	26	H>R		No	ClinGen gnomAD
TCGA novel	29	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1413502482 CA349581922	32	G>E		No	ClinGen gnomAD
CA60778382 rs866639518	33	S>*		No	ClinGen Ensembl
CA1964505 rs763792693	35	I>F		No	ClinGen ExAC gnomAD
rs1357785882 CA349581773	39	P>S		No	ClinGen TOPMed
CA349581758 rs1454373002	40	A>D		No	ClinGen TOPMed gnomAD
rs1454373002 CA349581753	40	A>V		No	ClinGen TOPMed gnomAD
rs1176628186 CA349581728	42	V>A		No	ClinGen gnomAD
CA349581735 rs1559162913	42	V>F		No	ClinGen Ensembl
TCGA novel	43	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA349581636 rs1574105160	46	N>K		No	ClinGen Ensembl
CA349581644 rs1441481800	46	N>S		No	ClinGen TOPMed gnomAD
rs758422964 CA1964490	48	W>*		No	ClinGen ExAC gnomAD
rs545647826 CA60762594	49	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA1964489 rs750317615	50	H>P		No	ClinGen ExAC gnomAD
CA349598508 rs1329946584	51	M>R		No	ClinGen TOPMed
rs765214248 CA1964488	52	Q>L		No	ClinGen ExAC gnomAD
rs1262500851 CA349598461 CA349598477	53	W>R		No	ClinGen gnomAD
rs756772158 CA1964487	54	S>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA1964486 rs753362824	55	K>E		No	ClinGen ExAC gnomAD
rs142587727 CA1964485	55	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs370506078 CA1964484	58	E>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA349598328 rs370506078	58	E>G		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	60	A>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs144459446 CA60762569	61	A>G		No	ClinGen ESP TOPMed gnomAD
rs775858124 CA1964482	62	R>G		No	ClinGen ExAC gnomAD
CA1964480 rs760042743	64	K>*		No	ClinGen ExAC TOPMed gnomAD
rs760042743 CA1964481	64	K>E		No	ClinGen ExAC TOPMed gnomAD
rs760042743 CA349598150	64	K>Q		No	ClinGen ExAC TOPMed gnomAD
rs563180068 CA60762560 COSM1148435 COSM717743	64	K>R	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA1964479 rs553730142	65	V>I		No	ClinGen 1000Genomes ExAC
CA349598074 rs1345704211	66	K>R		No	ClinGen gnomAD
rs1227930562 CA349597986	69	S>L		No	ClinGen TOPMed gnomAD
COSM1009533 rs779685244 CA60762534 COSM1153538	72	R>*	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs779685244 CA349597937	72	R>G		No	ClinGen TOPMed gnomAD
rs773311107 CA1964475	72	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA1964472 rs779998518	74	L>I		No	ClinGen ExAC gnomAD
CA1964471 rs772057584	78	Q>L		No	ClinGen ExAC gnomAD
CA1964449 rs778725277	80	K>T		No	ClinGen ExAC gnomAD
CA349593935 rs1439641407	82	E>D		No	ClinGen gnomAD
CA349593874 rs1179347905	85	A>T		No	ClinGen gnomAD
CA1964448 rs770799744	85	A>V		No	ClinGen ExAC gnomAD
rs749194619 CA1964447	86	S>C		No	ClinGen ExAC TOPMed gnomAD
rs1181951289 CA349593813	88	Y>H		No	ClinGen TOPMed
rs1207395792 CA349593767	89	W>C		No	ClinGen TOPMed gnomAD
rs1559068701 CA349593738	90	D>E		No	ClinGen Ensembl
rs1349503807 CA349593755	90	D>N		No	ClinGen gnomAD
CA349593665 rs1239264627	95	I>M		No	ClinGen gnomAD
rs550860135 CA1964445	96	H>R		No	ClinGen 1000Genomes ExAC gnomAD
rs1308840575 CA349593628	97	K>R		No	ClinGen gnomAD
CA349593623 rs1374313559	98	N>D		No	ClinGen gnomAD
CA1964443 rs752192049	98	N>S		No	ClinGen ExAC gnomAD
rs949953821 CA60750682	99	K>T		No	ClinGen TOPMed
rs1575756299 CA349593553	100	F>V		No	ClinGen Ensembl
rs1174359216 CA349593420	103	D>A		No	ClinGen gnomAD
TCGA novel	103	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1964441 rs780873428	104	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA349593395 rs780873428	104	R>G		No	ClinGen ExAC TOPMed gnomAD
rs754629409 CA1964440	104	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA60750674 rs780873428	104	R>S		No	ClinGen ExAC TOPMed gnomAD
CA349593288 rs1161709867	108	L>V		No	ClinGen gnomAD
rs751900891 CA1964439	110	E>*		No	ClinGen ExAC gnomAD
CA1964438 rs766708496	110	E>G		No	ClinGen ExAC gnomAD
CA349593123 rs1204988019	113	E>D		No	ClinGen TOPMed gnomAD
CA60750663 rs962892244	113	E>K		No	ClinGen gnomAD
rs751004894 CA1964436	116	P>A		No	ClinGen ExAC gnomAD
rs1351387302 CA349593025	117	V>F		No	ClinGen gnomAD
rs765823702 CA1964435	117	V>G		No	ClinGen ExAC gnomAD
TCGA novel	118	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1383081092 CA349592891	121	P>L		No	ClinGen TOPMed
rs1383081092 CA349592893	121	P>R		No	ClinGen TOPMed
CA1964434 rs762030842	121	P>S		No	ClinGen ExAC gnomAD
CA349592890 rs1229764801	122	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA349592777 rs1320819831	124	K>E		No	ClinGen gnomAD
CA1964433 rs534406035	125	A>V		No	ClinGen ExAC TOPMed gnomAD
rs774034063 CA1964430	127	E>*		No	ClinGen ExAC gnomAD
rs1213088166 CA349592663	127	E>G		No	ClinGen gnomAD
rs951303060 CA60750636	130	W>C		No	ClinGen Ensembl
CA1964429 rs770695920	130	W>R		No	ClinGen ExAC gnomAD
rs201147972 CA60750635	131	D>H		No	ClinGen Ensembl
CA60750626 rs917110978	133	V>A		No	ClinGen TOPMed
CA1964427 rs773192845	133	V>I		No	ClinGen ExAC gnomAD
rs773192845 CA349592457	133	V>L		No	ClinGen ExAC gnomAD
CA60750623 rs1026282136	135	T>I		No	ClinGen gnomAD
rs1201886612 CA349592339	136	S>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs185190720 CA1964425	137	A>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	137	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA349592284 rs1475966173	138	T>A		No	ClinGen gnomAD
CA349592270 rs1486697944	138	T>R		No	ClinGen Ensembl
rs1575755601 CA349592266	139	N>D		No	ClinGen Ensembl
CA349592230 rs141169319	140	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA1964422 rs141169319	140	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA349592218 rs1428343681	140	R>H		No	ClinGen TOPMed
rs141169319 CA1964423	140	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs779567642 CA1964421	141	F>L		No	ClinGen ExAC TOPMed gnomAD
rs61731489 CA349592162	142	S>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1964420 rs61731489	142	S>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs41268697 CA1964419	143	R>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs41268697 CA1964418	143	R>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1964417 rs757795211	145	H>P		No	ClinGen ExAC gnomAD
CA349591948 rs1437271204	147	P>R		No	ClinGen Ensembl
CA1964416 rs753984709	148	T>A		No	ClinGen ExAC TOPMed gnomAD
CA349591926 rs1263411004	148	T>I		No	ClinGen TOPMed gnomAD
CA349591934 rs1263411004	148	T>N		No	ClinGen TOPMed gnomAD
rs1007622200 CA60750581	150	P>S		No	ClinGen TOPMed
TCGA novel	151	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	152	E>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1268086760	154	N>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	155	H>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1278029561 CA349591579	155	H>Y		No	ClinGen Ensembl
rs1428766029 CA349591549	156	Y>H		No	ClinGen gnomAD
TCGA novel	156	Y>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA349591505 rs1214961554	158	K>E		No	ClinGen TOPMed
rs760815681 CA1964414	159	S>R		No	ClinGen ExAC TOPMed gnomAD
rs775852144 CA1964413	161	G>V		No	ClinGen ExAC gnomAD
CA349591241 rs1559067484	163	S>L		No	ClinGen Ensembl
rs140209595 CA1964410	169	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA349590976 rs1383220013	171	S>P		No	ClinGen gnomAD
CA1964409 rs151161397	175	N>D		No	ClinGen ESP ExAC gnomAD
CA349590791 rs1324275822	175	N>I		No	ClinGen gnomAD
CA349590789 rs748029510	175	N>K		No	ClinGen ExAC gnomAD
CA349590719 rs1394755919	177	D>E		No	ClinGen gnomAD
rs1169431086 CA349590702	178	S>Y		No	ClinGen gnomAD
rs776123567 CA1964407	179	E>K		No	ClinGen ExAC gnomAD
CA60750566 rs964351529	179	E>V		No	ClinGen TOPMed
rs1193315067 CA349590637	181	H>N		No	ClinGen gnomAD
rs1265246189 COSM1153537 CA349590621	181	H>Q	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
CA1964406 rs768278807	181	H>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA60750560 rs1017260954	182	K>E		No	ClinGen TOPMed
rs1443117275 CA349590516	184	G>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
TCGA novel	184	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA349590478 rs546766547	185	P>L		No	ClinGen 1000Genomes gnomAD
CA60750552 rs546766547	185	P>R		No	ClinGen 1000Genomes gnomAD
rs987751206 CA60750548	186	M>V		No	ClinGen TOPMed gnomAD
CA349590437 rs1257197013	187	E>K		No	ClinGen gnomAD
CA60750543 rs999520544	188	T>A		No	ClinGen Ensembl
CA1964404 rs779803133	192	P>R		No	ClinGen ExAC gnomAD
rs1337723441 CA349590202	192	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA349590166 rs1228306320	193	G>D		No	ClinGen gnomAD
rs1175012667 CA349590188	193	G>S		No	ClinGen gnomAD
rs1331018888 CA349590143	194	S>G		No	ClinGen gnomAD
rs757954897 CA1964403	195	N>H		No	ClinGen ExAC gnomAD
CA349590047 rs1443753782	195	N>S		No	ClinGen gnomAD
rs746264213 CA1964402	197	T>S		No	ClinGen ExAC TOPMed gnomAD
rs779367706 CA1964401	199	R>K		No	ClinGen ExAC TOPMed gnomAD
CA1964385 rs528516496	203	V>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1964384 rs528516496	203	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA349589441 rs1346261765	204	G>A		No	ClinGen TOPMed gnomAD
rs1346261765 CA349589442	204	G>D		No	ClinGen TOPMed gnomAD
CA60749755 rs1007415697	209	N>S		No	ClinGen TOPMed
rs1192793258 CA349589244	212	F>I		No	ClinGen TOPMed
rs1429130140 CA349589170	214	I>T		No	ClinGen TOPMed
CA1964380 rs749659566	215	L>F		No	ClinGen ExAC gnomAD
rs112280566 CA60749748	216	N>D		No	ClinGen Ensembl
rs1353208198 CA349588998	219	E>G		No	ClinGen gnomAD
CA349585533 rs1345754136	220	N>T		No	ClinGen gnomAD
TCGA novel	221	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1964362 rs367859843	222	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA1964363 rs774209016	222	P>S		No	ClinGen ExAC TOPMed gnomAD
CA349585500 rs774209016	222	P>T		No	ClinGen ExAC TOPMed gnomAD
rs770356561 CA1964359	223	E>A		No	ClinGen ExAC gnomAD
CA1964360 rs777961817	223	E>Q		No	ClinGen ExAC gnomAD
rs535397478 CA349585443	224	S>A		No	ClinGen ExAC TOPMed gnomAD
rs535397478 CA1964358	224	S>P		No	ClinGen ExAC TOPMed gnomAD
rs375267741 CA1964357	226	L>V		No	ClinGen ESP ExAC gnomAD
CA349585335 rs1243249382	228	C>R		No	ClinGen gnomAD
CA1964355 rs751615013	229	C>G		No	ClinGen ExAC gnomAD
CA60745613 rs71415241	229	C>W		No	ClinGen Ensembl
CA60745614 rs1005229081	229	C>Y		No	ClinGen gnomAD
CA349585214 rs1559052940	231	F>L		No	ClinGen Ensembl
CA349585194 rs1478904525	231	F>L		No	ClinGen TOPMed
rs1270232746 CA349585035	236	V>M		No	ClinGen gnomAD
CA349584998 rs1362552013	237	E>K		No	ClinGen gnomAD
CA1964350 rs187428286	239	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs752647081 CA1964349	240	K>N		No	ClinGen ExAC gnomAD
TCGA novel	242	H>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs142842112 CA349584355	243	S>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs142842112 CA1964330	243	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs768040586 CA349584242	246	R>I		No	ClinGen TOPMed gnomAD
CA60744676 rs768040586	246	R>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA349584221 rs1314850620	247	A>T		No	ClinGen TOPMed gnomAD
rs754926663 CA1964328	248	T>I		No	ClinGen ExAC gnomAD
rs1193349670 CA349584141	249	Q>*		No	ClinGen TOPMed
CA349584104 rs1575725285 CA349584116	249	Q>H		No	ClinGen Ensembl
rs1225641226 CA349584034	251	F>V		No	ClinGen gnomAD
rs751138034 CA1964327	254	V>F		No	ClinGen ExAC gnomAD
rs148050588 CA1964326	255	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA1964325 rs762672914	256	D>E		No	ClinGen ExAC gnomAD
CA349583874 rs1413070540	256	D>H		No	ClinGen TOPMed gnomAD
CA1964324 rs772797511	257	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA349583803 rs1343756171	258	C>R		No	ClinGen gnomAD
CA60744653 rs1036735514	258	C>Y		No	ClinGen TOPMed gnomAD
rs762122402 CA1964322	259	D>E		No	ClinGen ExAC gnomAD
rs1381658180 CA349583762	259	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
TCGA novel	261	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA349583494 rs1343376361	265	P>R		No	ClinGen gnomAD
CA1964321 rs141737189	267	P>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1964320 rs769171322	267	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs143561498 CA1964318	271	L>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs569087789 CA60744625	272	D>G		No	ClinGen 1000Genomes
CA60744614 rs917952029	273	V>A		No	ClinGen TOPMed
rs1292974606 CA349583212	273	V>I		No	ClinGen gnomAD
CA349583197 rs1226723956	274	I>V		No	ClinGen TOPMed
CA349583077 rs1231688914	277	V>I		No	ClinGen gnomAD
CA1964316 rs745951471	278	F>C		No	ClinGen ExAC TOPMed gnomAD
rs1383494548 CA349582999	279	V>G		No	ClinGen gnomAD
CA349583016 rs1382119565	279	V>M		No	ClinGen gnomAD
rs1290979078 CA349582993	280	L>F		No	ClinGen gnomAD
rs866962520 CA1964313	282	S>C		No	ClinGen TOPMed
rs866962520 CA349582881	282	S>Y		No	ClinGen TOPMed
CA1964312 rs757472686	283	I>V		No	ClinGen ExAC gnomAD
CA1964310 rs781086618	286	D>E		No	ClinGen ExAC gnomAD
rs959955896 CA60744559	286	D>G		No	ClinGen TOPMed gnomAD
rs772127069 CA1964311	286	D>H		No	ClinGen ExAC gnomAD
TCGA novel	286	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1964309 rs551304962	287	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA60741614 rs894390674	288	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs995469798 CA60741593	289	L>W		No	ClinGen TOPMed
rs779849767 CA1964262	291	I>V		No	ClinGen ExAC gnomAD

No associated diseases with Q9H825

1 regional properties for Q9H825

Type	Name	Position	InterPro Accession
domain	Methyltransferase domain 25	200 - 286	IPR041698

Functions

		Description
EC Number
Subcellular Localization	Mitochondrion	Mitochondrial protein: the cytoplasmic or nuclear localization observed by some groups is either the result of an incorrect localization caused by N-terminal tagging that interferes with mitochondrial targeting, or splice isoforms that lack the N-terminal mitochondrial transit sequence
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

2 GO annotations of molecular function

Name	Definition
mRNA methyltransferase activity	Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an mRNA molecule.
tRNA (cytosine-3-)-methyltransferase activity	Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 3-methylcytosine.

3 GO annotations of biological process

Name	Definition
mRNA methylation	The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule.
positive regulation of mitochondrial translation	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion.
tRNA C3-cytosine methylation	The process whereby a cytosine in a tRNA is methylated at position 3 of the cytosine.

4 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q86BS6	metl	Methyltransferase-like protein	Drosophila melanogaster (Fruit fly)	PR
Q6P1Q9	METTL2B	tRNA N(3)-methylcytidine methyltransferase METTL2B	Homo sapiens (Human)	PR
Q96IZ6	METTL2A	tRNA N(3)-methylcytidine methyltransferase METTL2A	Homo sapiens (Human)	PR
Q8BMK1	Mettl2	tRNA N(3)-methylcytidine methyltransferase METTL2	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MNMIWRNSIS	CLRLGKVPHR	YQSGYHPVAP	LGSRILTDPA	KVFEHNMWDH	MQWSKEEEAA
70	80	90	100	110	120
ARKKVKENSA	VRVLLEEQVK	YEREASKYWD	TFYKIHKNKF	FKDRNWLLRE	FPEILPVDQK
130	140	150	160	170	180
PEEKARESSW	DHVKTSATNR	FSRMHCPTVP	DEKNHYEKSS	GSSEGQSKTE	SDFSNLDSEK
190	200	210	220	230	240
HKKGPMETGL	FPGSNATFRI	LEVGCGAGNS	VFPILNTLEN	SPESFLYCCD	FASGAVELVK
250	260	270	280	290
SHSSYRATQC	FAFVHDVCDD	GLPYPFPDGI	LDVILLVFVL	SSIHPDRTLF	I