Q8BMK1

PR
Gene name
Mettl2
Protein name
tRNA N(3)-methylcytidine methyltransferase METTL2
Names
Methyltransferase-like protein 2
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:52686
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-95 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8BMK1

Entry ID Method Resolution Chain Position Source
AF-Q8BMK1-F1 Predicted AlphaFoldDB

29 variants for Q8BMK1

Variant ID(s) Position Change Description Diseaes Association Provenance
rs27005379 10 P>R No EVA
rs3402912373 85 H>L No EVA
rs3402719860 91 K>M No EVA
rs223448114 112 G>D No EVA
rs256281393 112 G>S No EVA
rs249808192 119 R>G No EVA
rs3402719845 133 Q>R No EVA
rs265890222 159 G>S No EVA
rs3389203245 180 V>I No EVA
rs3389179301 181 G>R No EVA
rs3389212060 204 C>R No EVA
rs3389220306 211 A>D No EVA
rs253056470 218 N>D No EVA
rs215007734 219 S>P No EVA
rs3389218924 235 D>E No EVA
rs3389220332 242 V>M No EVA
rs3389210195 266 K>* No EVA
rs3402838602 270 K>* No EVA
rs3403042498 272 S>C No EVA
rs3402859134 276 K>N No EVA
rs3402859096 276 K>Q No EVA
rs3389203216 298 K>I No EVA
rs3389179262 300 Q>H No EVA
rs232205864 329 A>T No EVA
rs3389207796 342 R>P No EVA
rs3389179290 343 L>* No EVA
rs3389203198 377 P>L No EVA
rs3389183579 377 P>S No EVA
rs3389210163 380 T>S No EVA

No associated diseases with Q8BMK1

1 regional properties for Q8BMK1

Type Name Position InterPro Accession
domain Methyltransferase type 12 178 - 280 IPR013217

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
tRNA (cytosine) methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylcytosine.
tRNA (cytosine-3-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 3-methylcytosine.

1 GO annotations of biological process

Name Definition
tRNA methylation The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q86BS6 metl Methyltransferase-like protein Drosophila melanogaster (Fruit fly) PR
Q9H825 METTL8 tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial Homo sapiens (Human) PR
Q6P1Q9 METTL2B tRNA N(3)-methylcytidine methyltransferase METTL2B Homo sapiens (Human) PR
Q96IZ6 METTL2A tRNA N(3)-methylcytidine methyltransferase METTL2A Homo sapiens (Human) PR
10 20 30 40 50 60
MAASFPEGVP ETEDGKRPQF GHRFLSDPAR VFHHNAWDNV KWSEEQAAAA ERKVQENSSP
70 80 90 100 110 120
LVCPEKQVDY EVNAHKYWDD FYRIHENGFF KDRHWLFTEF PELAPSHSHL TGVPLEKQRS
130 140 150 160 170 180
DVCEDGPGLT AEQHKCSCAS PGCETQVPPL EEPVTQKLGH LEISGEEFPG SSATYRILEV
190 200 210 220 230 240
GCGVGNTVFP ILQTNNNPNL FVYCCDFSAT AIELLKTNSQ YDPSRCYAFV HDLCDEDQSY
250 260 270 280 290 300
PVPEDSLDVI VLIFVLSAIV PDKMQKAISK LSRLLKPGGV MLLRDYGRYD MAQLRFKKGQ
310 320 330 340 350 360
CLSGNFYVRG DGTRVYFFTQ GELDTLFTAA GLEKVQNLVD RRLQVNRGKQ LTMYRVWIQC
370 380
KYSKPLALRS SQHVPIPHAT ESSSHSGLL