AiPD: Autoinhibited Protein Database

Q6P1Q9

Gene name	METTL2B
Protein name	tRNA N(3)-methylcytidine methyltransferase METTL2B
Names	Methyltransferase-like protein 2B
Species	Homo sapiens (Human)
KEGG Pathway	hsa:55798
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

20-93 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

20-93 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q6P1Q9

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q6P1Q9-F1	Predicted				AlphaFoldDB

328 variants for Q6P1Q9

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs754003835 CA4471381	2	A>G		No	ClinGen ExAC TOPMed gnomAD
rs754003835 CA369165911	2	A>V		No	ClinGen ExAC TOPMed gnomAD
rs755214059 CA4471382	3	G>C		No	ClinGen ExAC TOPMed gnomAD
CA4471383 rs755214059	3	G>R		No	ClinGen ExAC TOPMed gnomAD
rs755214059 CA369165923	3	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1293788812 CA369165947	3	G>V		No	ClinGen TOPMed
CA369165998 rs1310043389	5	Y>C		No	ClinGen gnomAD
TCGA novel	6	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs144880655 CA4471385	6	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA4471386 rs199977243	7	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4471387 rs747552289	9	A>E		No	ClinGen ExAC gnomAD
rs747552289 CA4471388	9	A>V		No	ClinGen ExAC gnomAD
rs550317475 CA4471391	10	P>L		No	ClinGen 1000Genomes ExAC gnomAD
rs1394754844 CA369166144	11	A>T		No	ClinGen gnomAD
CA369166163 rs1412966256	11	A>V		No	ClinGen gnomAD
rs996729949 CA166137651	12	I>S		No	ClinGen TOPMed gnomAD
CA166137640 rs751924382	12	I>V		No	ClinGen Ensembl
CA369166274 rs888039767	15	D>A		No	ClinGen TOPMed
rs888039767 CA166137672	15	D>G		No	ClinGen TOPMed
rs760621027 CA4471396	15	D>N		No	ClinGen ExAC gnomAD
CA4471397 rs766150434	16	K>R		No	ClinGen ExAC gnomAD
CA369166368 rs1442153563	17	R>W		No	ClinGen gnomAD
CA4471399 rs368817993	18	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA4471401 rs765429745	19	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA369166468 rs1368465293	20	F>S		No	ClinGen TOPMed
rs1315756716 CA369166483	21	G>E		No	ClinGen gnomAD
rs752988826 CA4471402	21	G>R		No	ClinGen ExAC gnomAD
CA369166533 rs1421788567	23	R>Q		No	ClinGen gnomAD
rs143388299 CA4471404	25	L>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4471405 rs764272437	25	L>P		No	ClinGen ExAC gnomAD
rs1208379883 CA369166610	26	S>N		No	ClinGen TOPMed
CA4471406 rs752051606	26	S>R		No	ClinGen ExAC TOPMed gnomAD
CA369166597 rs1246366047	26	S>R		No	ClinGen TOPMed
rs1244765041 CA369166635	27	D>H		No	ClinGen gnomAD
CA4471408 rs781683949	28	P>L		No	ClinGen ExAC TOPMed gnomAD
CA4471409 rs746258006	29	A>S		No	ClinGen ExAC gnomAD
CA4471410 rs754635858	29	A>V		No	ClinGen ExAC TOPMed gnomAD
rs969939104 CA166137818	30	R>G		No	ClinGen TOPMed gnomAD
CA4471411 rs778379366	30	R>L		No	ClinGen ExAC gnomAD
CA369166763 rs969939104	30	R>S		No	ClinGen TOPMed gnomAD
CA369166880 rs1325655959	34	H>R		No	ClinGen TOPMed gnomAD
CA4471414 rs772768554	36	A>G		No	ClinGen ExAC TOPMed gnomAD
CA369166940 rs771514640	36	A>S		No	ClinGen ExAC TOPMed gnomAD
CA4471413 rs771514640	36	A>T		No	ClinGen ExAC TOPMed gnomAD
CA4471415 rs772768554	36	A>V		No	ClinGen ExAC TOPMed gnomAD
CA4471416 rs770895217	37	W>R		No	ClinGen ExAC gnomAD
rs1409074735 CA369167137	38	D>G		No	ClinGen TOPMed
CA4471438 rs763259775	38	D>H		No	ClinGen ExAC gnomAD
rs764446464 CA369167151	39	N>I		No	ClinGen ExAC TOPMed gnomAD
rs764446464 CA4471439	39	N>S		No	ClinGen ExAC TOPMed gnomAD
CA369167182 rs1467841190	40	V>M		No	ClinGen gnomAD
rs201840388 CA166138109	41	E>Q		No	ClinGen 1000Genomes
CA369167238 rs1584787303	42	W>G		No	ClinGen Ensembl
rs747240198 CA4471441	42	W>V		No	ClinGen ExAC
rs1409602134 CA369167312	43	S>L		No	ClinGen TOPMed
rs1483559110 CA369167404	46	Q>E		No	ClinGen TOPMed
CA4471443 rs774550663	47	A>T		No	ClinGen ExAC gnomAD
CA369167508 rs1168918849	48	A>V		No	ClinGen gnomAD
CA4471444 rs761934718	50	A>G		No	ClinGen ExAC gnomAD
CA369167598 rs1244045658	52	R>G		No	ClinGen TOPMed gnomAD
rs1427441452 CA369167616	52	R>S		No	ClinGen gnomAD
CA166138157 rs542693830	53	K>R		No	ClinGen 1000Genomes
rs1175079536 CA369167652	55	Q>*		No	ClinGen gnomAD
rs767735930 CA4471445	55	Q>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA4471446 rs750826327	56	E>*		No	ClinGen ExAC gnomAD
CA369167688 rs750826327	56	E>K		No	ClinGen ExAC gnomAD
rs761304206 CA4471447	58	S>N		No	ClinGen ExAC gnomAD
rs1563025675 CA369167831	59	I>N		No	ClinGen Ensembl
CA369167908 rs1339747271	61	R>P		No	ClinGen TOPMed gnomAD
rs1269384472 CA369167885	61	R>W		No	ClinGen gnomAD
CA4471449 rs754270290	62	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1282784635 CA369168010	64	Q>P		No	ClinGen gnomAD
rs758023816 CA4471450	65	E>K		No	ClinGen ExAC gnomAD
rs777360306 CA4471451	66	K>E		No	ClinGen ExAC gnomAD
rs1449236159 CA369168118	67	Q>*		No	ClinGen gnomAD
VAR_059465 CA4471452 rs2288557	68	V>I		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA4471453 rs2288557	68	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA369169759 rs1307505150	69	D>V		No	ClinGen gnomAD
CA4471480 rs772380517	70	Y>F		No	ClinGen ExAC TOPMed gnomAD
CA369169867 rs1584788301	71	E>Q		No	ClinGen Ensembl
CA4471481 rs773144378	72	I>N		No	ClinGen ExAC gnomAD
CA4471482 rs558538474	73	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4471483 rs770950888	74	A>G		No	ClinGen ExAC gnomAD
CA369170064 rs1264450413	77	Y>C		No	ClinGen TOPMed
CA4471485 rs760052603	78	W>*		No	ClinGen ExAC gnomAD
rs1480755207 CA369170137	80	D>N		No	ClinGen gnomAD
rs1480755207 CA369170139	80	D>Y		No	ClinGen gnomAD
rs1203919311 CA369170168	81	F>C		No	ClinGen gnomAD
CA4471486 rs577815271	82	Y>*		No	ClinGen 1000Genomes ExAC gnomAD
CA4471488 rs761337639	84	I>N		No	ClinGen ExAC TOPMed gnomAD
CA4471489 rs761337639	84	I>T		No	ClinGen ExAC TOPMed gnomAD
rs775896759 CA4471487	84	I>V		No	ClinGen ExAC TOPMed gnomAD
rs750061884 CA4471490	85	H>L		No	ClinGen ExAC TOPMed gnomAD
rs750061884 CA369170278	85	H>R		No	ClinGen ExAC TOPMed gnomAD
CA4471492 rs765990831	86	E>K		No	ClinGen ExAC TOPMed gnomAD
rs545309739 CA4471493	88	G>E		No	ClinGen 1000Genomes ExAC gnomAD
CA4471494 rs755022379	90	F>I		No	ClinGen ExAC TOPMed gnomAD
rs778821569 CA4471495	91	K>E		No	ClinGen ExAC gnomAD
CA4471496 rs748007739	92	D>G		No	ClinGen ExAC gnomAD
TCGA novel	92	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	92	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs758149529 CA4471497	93	R>G		No	ClinGen ExAC
rs1452036402 CA369170739	94	H>R		No	ClinGen TOPMed
TCGA novel	94	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs747204364 CA4471499	95	W>*		No	ClinGen ExAC gnomAD
CA4471498 rs778016179	95	W>R		No	ClinGen ExAC gnomAD
CA166139340 rs909946449	96	L>F		No	ClinGen TOPMed
rs1159707216 CA369170826	97	F>L		No	ClinGen TOPMed
CA4471502 rs776752874	99	E>*		No	ClinGen ExAC TOPMed gnomAD
CA4471501 rs776752874	99	E>K	Variant assessed as Somatic; 4.62e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1227251220 CA369170984	100	F>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	101	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs770322966 CA4471503	101	P>S		No	ClinGen ExAC gnomAD
rs370934585 CA4471506	104	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA4471507 rs772854007	105	P>S		No	ClinGen ExAC TOPMed gnomAD
rs760256690 CA4471508	106	S>G		No	ClinGen ExAC
rs372947759 CA166139444	107	Q>E		No	ClinGen ESP TOPMed gnomAD
CA166139451 rs765973988	107	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs1448606188 CA369171424	109	Q>P		No	ClinGen gnomAD
rs1563026260 CA369171447	110	N>T		No	ClinGen Ensembl
CA369171488 rs1218532117	111	H>N		No	ClinGen TOPMed
rs754946655 CA4471511	112	L>S		No	ClinGen ExAC TOPMed gnomAD
rs147091233 CA4471513	115	W>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1465000373 CA369171637	116	F>L		No	ClinGen gnomAD
CA369171650 rs1291101702	116	F>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA4471514 rs758149729	117	L>S		No	ClinGen ExAC gnomAD
COSM345898 rs777446288 CA4471515	118	E>K	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA369171702 rs1563026281	119	N>Y		No	ClinGen Ensembl
CA369171779 rs1295847185	121	S>N		No	ClinGen gnomAD
CA4471516 rs2896399 COSM1131716 VAR_042547	124	C>R	prostate [Cosmic]	No	ClinGen cosmic curated UniProt ExAC TOPMed dbSNP gnomAD
rs1053120 CA4471517 COSM3662914	124	C>S	liver [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA4471518 rs781215137	126	C>F		No	ClinGen ExAC gnomAD
rs1217904465 CA369172099	128	N>K		No	ClinGen TOPMed gnomAD
rs2023329 CA369172103	129	N>D		No	ClinGen gnomAD
rs2023329 VAR_042548 CA166139564	129	N>H		No	ClinGen UniProt dbSNP gnomAD
TCGA novel	130	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4471520 rs769881145	133	P>L		No	ClinGen ExAC gnomAD
CA369172279 rs1206659231	133	P>S		No	ClinGen gnomAD
CA4471522 rs749762340	134	G>A		No	ClinGen ExAC gnomAD
CA369172302 rs749762340	134	G>D		No	ClinGen ExAC gnomAD
TCGA novel	134	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA369172341 rs1424585878	135	L>F		No	ClinGen gnomAD
rs138655370 CA4471523	136	I>L		No	ClinGen 1000Genomes ExAC gnomAD
CA4471524 rs774634239	136	I>T		No	ClinGen ExAC gnomAD
rs1317297850 CA369172548	141	H>Y		No	ClinGen TOPMed
CA4471525 rs542722736	142	K>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs138363960 CA4471527	143	C>Y		No	ClinGen ESP ExAC TOPMed
COSM1085244 rs199814237 CA4471528	145	S>L	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs370330757 CA4471533	149	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA369172908 rs1365015595	150	H>D		No	ClinGen gnomAD
CA4471534 rs757446547	150	H>R		No	ClinGen ExAC gnomAD
CA369172909 rs1365015595	150	H>Y		No	ClinGen gnomAD
CA369172994 rs1242070922	152	T>A		No	ClinGen TOPMed
rs781338814 CA4471535	152	T>I		No	ClinGen ExAC gnomAD
CA4471536 rs750671733	153	Q>*		No	ClinGen ExAC gnomAD
CA4471537 rs750671733	153	Q>E		No	ClinGen ExAC gnomAD
rs780011703 CA4471538	153	Q>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA369173016 rs1223636203	153	Q>R		No	ClinGen TOPMed
rs71376910 CA166139747	155	P>L		No	ClinGen Ensembl
rs543399916 CA4471542	159	E>D		No	ClinGen 1000Genomes ExAC gnomAD
rs531322856 CA4471541	159	E>K		No	ClinGen 1000Genomes ExAC gnomAD
rs200760710 CA4471543	162	T>I		No	ClinGen ExAC TOPMed gnomAD
CA369173278 rs200760710	162	T>S		No	ClinGen ExAC TOPMed gnomAD
CA369173283 rs1184525986	163	Q>*		No	ClinGen TOPMed gnomAD
rs759278722 CA4471545 COSM1447893	166	S>G	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1212891370 CA369173388	167	D>G		No	ClinGen TOPMed
rs1065267 CA4471546 VAR_042549	169	E>K		No	ClinGen UniProt 1000Genomes TOPMed dbSNP gnomAD
rs1269551545 CA369173522	174	E>*		No	ClinGen TOPMed
CA4471548 rs374382100	174	E>V		No	ClinGen ESP ExAC gnomAD
rs376032047 CA4471549	176	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs376032047 CA4471550	176	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs937655357 CA166139773	176	P>S		No	ClinGen TOPMed gnomAD
rs1443838938 CA369173581	177	G>R		No	ClinGen gnomAD
rs1349278312 CA369173640 COSM1312658	179	S>L	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1226525990 CA369173659	180	A>G		No	ClinGen gnomAD
TCGA novel	182	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4471552 rs564898982	183	R>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs564898982 CA4471553	183	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs767300402 CA4471554	183	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1054909731 CA166139788	186	E>A		No	ClinGen TOPMed
rs1171845417 CA369173758	186	E>Q		No	ClinGen TOPMed
CA4471568 rs748694427	187	V>I		No	ClinGen ExAC TOPMed gnomAD
rs374470199 CA4471569	189	C>Y		No	ClinGen ESP ExAC gnomAD
rs1203188545 CA369173887	190	G>C		No	ClinGen gnomAD
CA4471571 rs761751374	191	V>A		No	ClinGen ExAC gnomAD
rs368420732 CA4471570	191	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs570735134 CA4471574	193	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA369173926 rs570735134	193	N>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1451758127 CA369173939	194	T>A		No	ClinGen gnomAD
rs1346963830 CA369173944	194	T>I		No	ClinGen TOPMed
TCGA novel	195	V>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1238049186 CA369173974	196	F>L		No	ClinGen gnomAD
CA166140312 rs933745096	198	I>T		No	ClinGen TOPMed gnomAD
rs535064523 CA4471575	198	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4471576 rs766464173	201	T>M		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	202	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs547363955 CA4471579	203	N>S		No	ClinGen 1000Genomes ExAC gnomAD
rs1390822237 CA369176283	204	D>G		No	ClinGen TOPMed gnomAD
rs1173833068 CA369176314	206	G>A		No	ClinGen gnomAD
rs1319658735 CA369176318	207	L>V		No	ClinGen gnomAD
CA369176557 rs1383720205	213	D>G		No	ClinGen TOPMed
CA369176829 rs1331872957	221	L>V		No	ClinGen gnomAD
CA4471600 rs143926368	222	V>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4471601 rs143926368	222	V>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4471599 rs752867018	222	V>L		No	ClinGen ExAC gnomAD
rs532613589 CA4471640	228	Y>C		No	ClinGen 1000Genomes ExAC gnomAD
CA4471641 rs184377510	229	D>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA369179033 rs1296412142	229	D>N		No	ClinGen gnomAD
TCGA novel	231	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4471642 rs201069711	232	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA4471643 rs201069711	232	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1003182800 CA166145844	232	R>W		No	ClinGen TOPMed gnomAD
rs140437785 COSM110182 CA166145859	233	C>G	skin [Cosmic]	No	ClinGen cosmic curated Ensembl
rs1275149315 CA369179190	234	F>L		No	ClinGen gnomAD
rs1230094773 CA369179177	234	F>S		No	ClinGen gnomAD
rs150648939 CA4471645	239	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1240633988 CA369179444	241	C>F		No	ClinGen gnomAD
rs991406855 CA166145877	244	E>*		No	ClinGen TOPMed
rs1247592921 CA369179537	245	K>E		No	ClinGen TOPMed
rs756743733 CA4471647	246	S>G		No	ClinGen ExAC TOPMed gnomAD
CA4471650 rs755911877	247	Y>*		No	ClinGen ExAC gnomAD
rs745794267 CA4471649	247	Y>H		No	ClinGen ExAC gnomAD
CA4471654 rs139684664	252	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs769038355 CA4471653	252	G>S		No	ClinGen ExAC gnomAD
CA4471655 rs748209056	253	S>G		No	ClinGen ExAC gnomAD
rs1343043459 CA369179872	256	I>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA369179934 rs1288961374	259	L>V		No	ClinGen gnomAD
rs924164768 CA166145933	260	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs773711845 CA4471657	261	F>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	263	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	263	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs761229854 CA4471658	264	S>L		No	ClinGen ExAC TOPMed gnomAD
rs1291674579 CA369180055	265	A>T		No	ClinGen TOPMed gnomAD
CA4471659 VAR_042550 rs2562741	266	V>I		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA4471661 rs762574753	268	P>L		No	ClinGen ExAC gnomAD
rs751206752 CA4471663	269	D>E		No	ClinGen ExAC gnomAD
rs763756064 CA4471662	269	D>G		No	ClinGen ExAC gnomAD
rs1268307356 CA369180154	269	D>N		No	ClinGen gnomAD
rs756723202 CA4471664	270	K>T		No	ClinGen ExAC TOPMed gnomAD
CA4471688 rs753857299	271	M>T		No	ClinGen ExAC gnomAD
CA4471690 rs778630920	273	K>E		No	ClinGen ExAC TOPMed gnomAD
rs752960141 CA4471691	274	A>P		No	ClinGen ExAC gnomAD
rs752960141 CA4471692	274	A>S		No	ClinGen ExAC gnomAD
rs369463525 CA166147397	275	I>V		No	ClinGen ESP TOPMed gnomAD
rs372796185 CA4471693	276	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA369182109 rs1230818152	276	N>S		No	ClinGen gnomAD
CA369182172 rs1338785540	279	S>N		No	ClinGen gnomAD
rs1398708341 CA369182188	280	R>G		No	ClinGen TOPMed gnomAD
rs771033957 CA4471695	282	L>V		No	ClinGen ExAC TOPMed gnomAD
CA4471696 rs202185157	283	K>E		No	ClinGen ExAC TOPMed gnomAD
CA369182296 rs1563031122	284	P>L		No	ClinGen Ensembl
CA4471699 rs551970224	285	G>E		No	ClinGen 1000Genomes ExAC gnomAD
CA4471698 rs746392126	285	G>R		No	ClinGen ExAC gnomAD
rs376427235 CA4471701	286	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	287	M>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4471703 rs773019533	288	V>A		No	ClinGen ExAC gnomAD
rs760221605 CA4471704	290	L>V		No	ClinGen ExAC TOPMed gnomAD
rs567098989 CA4471705	291	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs375503082 CA166147458	291	R>Q		No	ClinGen TOPMed gnomAD
CA369182476 rs1584797276	293	Y>S		No	ClinGen Ensembl
CA4471707 rs759459489	294	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs549497239 CA4471708	295	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs376529256 CA166147483	295	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA4471709 rs376529256	295	R>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA369182522 rs376529256	295	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA369182546 rs1346339708	296	Y>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1223380353 CA369182560	297	D>N		No	ClinGen gnomAD
CA4471711 rs758237793	300	Q>*		No	ClinGen ExAC gnomAD
rs73232665 CA4471715	302	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs73232665 CA4471714	302	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4471713 rs148691648	302	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	306	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA369184167 rs1229469212	306	G>V		No	ClinGen gnomAD
CA4471731 rs372175253	307	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1348116657 CA369184206	308	C>W		No	ClinGen gnomAD
TCGA novel	309	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs767549823 CA4471734	314	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs139332186 CA4471737	315	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs139332186 CA4471736	315	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	316	R>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA369184344 rs1180835599	317	G>R		No	ClinGen gnomAD
rs1451933725 CA369184437	322	V>I		No	ClinGen gnomAD
CA4471741 rs746630236	323	Y>H		No	ClinGen ExAC
CA369184499 rs1168686158	325	F>S		No	ClinGen TOPMed
rs1366401568 CA369184523	326	T>S		No	ClinGen gnomAD
rs1301369783 CA369184564	328	E>K		No	ClinGen TOPMed gnomAD
rs768625890 CA4471765	330	L>R		No	ClinGen ExAC gnomAD
CA4471767 rs144033501	332	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs372160652 CA4471769	333	L>F		No	ClinGen ESP ExAC TOPMed
rs1242244191 CA369184780	335	T>P		No	ClinGen gnomAD
rs761016035 CA4471771	340	E>A		No	ClinGen ExAC gnomAD
rs766337756 CA4471772	342	V>A		No	ClinGen ExAC gnomAD
CA369184882 rs759709919	343	Q>*		No	ClinGen ExAC gnomAD
rs759709919 CA4471774	343	Q>E		No	ClinGen ExAC gnomAD
CA369184895 rs1053124	344	N>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs758775623 CA4471777	348	R>C		No	ClinGen ExAC gnomAD
CA4471778 rs376554951	348	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1381225752 CA369184921	349	R>*		No	ClinGen TOPMed gnomAD
rs750035208 CA4471779	349	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA4471780 rs755834988	350	L>M		No	ClinGen ExAC TOPMed gnomAD
CA369184925 rs1223991931	350	L>Q		No	ClinGen gnomAD
rs748750939 CA4471782	351	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs768188038 CA4471783	353	N>D		No	ClinGen ExAC gnomAD
rs1584799076 CA369184943	353	N>T		No	ClinGen Ensembl
rs748092719 CA4471785	354	R>*		No	ClinGen ExAC TOPMed gnomAD
rs748092719 CA369184948	354	R>G		No	ClinGen ExAC TOPMed gnomAD
CA4471786 rs369496166	354	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA369184971 rs1163244735	357	Q>H		No	ClinGen TOPMed
rs1435452905 CA369184977	358	L>P		No	ClinGen gnomAD
CA369184991 rs1429353047	360	M>I		No	ClinGen TOPMed
CA4471787 rs773126594	360	M>T		No	ClinGen ExAC gnomAD
rs760785211 CA4471788	361	Y>H		No	ClinGen ExAC TOPMed gnomAD
rs149666702 CA4471790	362	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA4471789 rs771135202	362	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA369185002 rs759620083	363	V>I		No	ClinGen ExAC TOPMed gnomAD
rs759620083 CA4471791	363	V>L		No	ClinGen ExAC TOPMed gnomAD
CA369185012 rs1222915539	364	W>C		No	ClinGen TOPMed
CA4471792 rs765418575	364	W>R		No	ClinGen ExAC
CA4471793 rs753239204	366	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA369185031 rs1452533494	367	C>R		No	ClinGen gnomAD
CA4471794 rs373453923	367	C>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA369185032 rs1286634711	367	C>Y		No	ClinGen gnomAD
CA369185047 rs1584799110	369	Y>S		No	ClinGen Ensembl
CA369185053 rs1221197189	370	C>R		No	ClinGen TOPMed
CA4471796 rs752008206	372	P>R		No	ClinGen ExAC gnomAD
CA4471799 rs753496451	375	S>F		No	ClinGen ExAC gnomAD
CA4471800 rs754429158	376	S>T		No	ClinGen ExAC gnomAD
rs1317764509 CA369185106	378	S>T		No	ClinGen gnomAD

No associated diseases with Q6P1Q9

No regional properties for Q6P1Q9

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q6P1Q9

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name	Definition
tRNA (cytosine) methyltransferase activity	Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylcytosine.
tRNA (cytosine-3-)-methyltransferase activity	Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 3-methylcytosine.

1 GO annotations of biological process

Name	Definition
tRNA methylation	The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule.

4 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q86BS6	metl	Methyltransferase-like protein	Drosophila melanogaster (Fruit fly)	PR
Q9H825	METTL8	tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial	Homo sapiens (Human)	PR
Q96IZ6	METTL2A	tRNA N(3)-methylcytidine methyltransferase METTL2A	Homo sapiens (Human)	PR
Q8BMK1	Mettl2	tRNA N(3)-methylcytidine methyltransferase METTL2	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MAGSYPEGAP	AILADKRQQF	GSRFLSDPAR	VFHHNAWDNV	EWSEEQAAAA	ERKVQENSIQ
70	80	90	100	110	120
RVCQEKQVDY	EINAHKYWND	FYKIHENGFF	KDRHWLFTEF	PELAPSQNQN	HLKDWFLENK
130	140	150	160	170	180
SEVCECRNNE	DGPGLIMEEQ	HKCSSKSLEH	KTQTPPVEEN	VTQKISDLEI	CADEFPGSSA
190	200	210	220	230	240
TYRILEVGCG	VGNTVFPILQ	TNNDPGLFVY	CCDFSSTAIE	LVQTNSEYDP	SRCFAFVHDL
250	260	270	280	290	300
CDEEKSYPVP	KGSLDIIILI	FVLSAVVPDK	MQKAINRLSR	LLKPGGMVLL	RDYGRYDMAQ
310	320	330	340	350	360
LRFKKGQCLS	GNFYVRGDGT	RVYFFTQEEL	DTLFTTAGLE	KVQNLVDRRL	QVNRGKQLTM
370
YRVWIQCKYC	KPLLSSTS