Q86BS6

PR
Gene name
metl (CG13929)
Protein name
Methyltransferase-like protein
Names
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG13929
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

42-112 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q86BS6

Entry ID Method Resolution Chain Position Source
AF-Q86BS6-F1 Predicted AlphaFoldDB

No variants for Q86BS6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q86BS6

No associated diseases with Q86BS6

1 regional properties for Q86BS6

Type Name Position InterPro Accession
domain Methyltransferase domain 25 136 - 238 IPR041698

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
tRNA (cytosine) methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylcytosine.
tRNA (cytosine-3-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 3-methylcytosine.

1 GO annotations of biological process

Name Definition
tRNA methylation The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9H825 METTL8 tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial Homo sapiens (Human) PR
Q6P1Q9 METTL2B tRNA N(3)-methylcytidine methyltransferase METTL2B Homo sapiens (Human) PR
Q96IZ6 METTL2A tRNA N(3)-methylcytidine methyltransferase METTL2A Homo sapiens (Human) PR
Q8BMK1 Mettl2 tRNA N(3)-methylcytidine methyltransferase METTL2 Mus musculus (Mouse) PR
10 20 30 40 50 60
MLTTSSSTML GKYGWQILRR LASKSWEHTR QRKKPSGAGS RVLTDAREVF EFNAWDHVQW
70 80 90 100 110 120
DEEQELAAKA AVAKNSTSKM EAEQKERFQT DAPKFWDSFY GIHDNRFFKD RHWLFTEFPE
130 140 150 160 170 180
LAPLAADSAV LQPRSIFELG CGVGNTILPL LQYSSEPQLK VFGCDFSARA IEILRSQRQF
190 200 210 220 230 240
DEKRCEVFVM DATLDHWQVP FEENSQDIIV MIFVLSAIEP KKMQRVLDNC YRYLRPGGLL
250 260 270 280 290 300
LFRDYGRYDL AQLRFKSGKC MEDNFYVRGD GTMVYFFTEE ELRGMMTQAG LQEEQLIVDR
310 320
RLQVNRCRGL KMYRVWIQTK FRKPL