Q9H467
PR
Gene name |
CUEDC2 (C10orf66, HOYS6) |
Protein name |
CUE domain-containing protein 2 |
Names |
|
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:79004 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9H467
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9H467-F1 | Predicted | AlphaFoldDB |
189 variants for Q9H467
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| TCGA novel | 2 | E>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA377895645 rs759596094 |
3 | L>M | No |
ClinGen ExAC gnomAD |
|
|
rs776855352 CA5666514 |
5 | R>G | No |
ClinGen ExAC gnomAD |
|
|
rs771132275 CA5666513 |
7 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1337608179 CA377895604 |
9 | A>T | No |
ClinGen gnomAD |
|
|
rs1471019718 CA377895601 |
9 | A>V | No |
ClinGen gnomAD |
|
| TCGA novel | 11 | L>P | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA377895586 rs1565236954 |
12 | L>F | No |
ClinGen Ensembl |
|
|
CA377895564 rs1171984613 |
15 | V>A | No |
ClinGen gnomAD |
|
|
CA377895546 rs1374658234 |
18 | H>Y | No |
ClinGen gnomAD |
|
|
CA377895537 rs1589907223 |
19 | L>H | No |
ClinGen Ensembl |
|
|
rs562865002 CA5666510 |
20 | P>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA377895509 rs1589907211 |
23 | D>E | No |
ClinGen Ensembl |
|
|
CA5666506 rs532839181 |
23 | D>N | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA5666480 rs556077135 |
26 | G>D | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA5666479 rs779358967 |
27 | L>F | No |
ClinGen ExAC gnomAD |
|
|
rs1403337970 CA377895198 |
29 | E>K | No |
ClinGen gnomAD |
|
|
rs1412678621 CA377895182 |
30 | V>L | No |
ClinGen gnomAD |
|
|
CA377895173 rs1158754396 |
31 | I>L | No |
ClinGen TOPMed gnomAD |
|
|
rs1379906944 CA377895139 |
33 | S>F | No |
ClinGen gnomAD |
|
|
CA377895128 rs1177735968 |
34 | Y>* | No |
ClinGen gnomAD |
|
|
CA377895137 rs1308546068 |
34 | Y>H | No |
ClinGen TOPMed |
|
|
rs1009621265 CA212227377 |
37 | G>V | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 43 | G>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs201349133 CA5666475 |
45 | S>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs201349133 CA212227366 |
45 | S>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA212227342 rs917018551 |
49 | E>Q | No |
ClinGen Ensembl |
|
|
rs1331387636 CA377894960 |
50 | E>D | No |
ClinGen gnomAD |
|
|
rs1224539667 CA377894963 |
50 | E>G | No |
ClinGen gnomAD |
|
|
CA377894934 rs767718515 |
53 | D>H | No |
ClinGen ExAC gnomAD |
|
|
COSM122428 rs767718515 CA5666473 |
53 | D>N | upper_aerodigestive_tract Variant assessed as Somatic; 0.0 impact. large_intestine [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
CA5666472 rs373065366 CA212227337 |
54 | M>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1349083065 CA377894911 |
55 | E>Q | No |
ClinGen gnomAD |
|
|
CA5666471 rs774191179 |
56 | A>G | No |
ClinGen ExAC TOPMed |
|
| TCGA novel | 56 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA377894838 rs1168244291 |
61 | M>L | No |
ClinGen TOPMed |
|
|
rs768512209 CA5666470 |
62 | E>G | No |
ClinGen ExAC gnomAD |
|
|
CA5666469 rs543918496 |
65 | V>A | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs769457340 CA5666467 |
66 | P>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5666466 rs745317739 |
67 | G>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA212227325 rs978998158 |
69 | A>T | No |
ClinGen TOPMed gnomAD |
|
|
rs1216883456 CA377894739 |
69 | A>V | No |
ClinGen gnomAD |
|
|
rs748506038 CA5666464 |
73 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5666463 rs748506038 |
73 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5666448 rs201476465 |
74 | G>D | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs759187478 CA5666447 |
78 | D>E | No |
ClinGen ExAC gnomAD |
|
|
CA377894614 rs1257844400 |
78 | D>G | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs776178971 CA5666446 |
79 | M>T | No |
ClinGen ExAC gnomAD |
|
|
rs1328658096 CA377894583 |
80 | M>I | No |
ClinGen gnomAD |
|
|
rs1334771034 CA377894589 |
80 | M>K | No |
ClinGen gnomAD |
|
|
rs1344077076 CA377894575 |
81 | Q>R | No |
ClinGen TOPMed |
|
|
CA5666445 rs770543867 |
85 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs777252458 CA5666443 |
89 | D>N | No |
ClinGen ExAC gnomAD |
|
|
CA377894472 rs1465076996 |
91 | R>G | No |
ClinGen gnomAD |
|
|
rs749599580 CA5666441 |
92 | N>K | No |
ClinGen ExAC gnomAD |
|
|
CA5666420 rs781511061 |
94 | E>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1404927148 CA377894449 |
94 | E>Q | No |
ClinGen TOPMed |
|
|
CA212227184 rs895449456 |
94 | E>V | No |
ClinGen Ensembl |
|
|
rs757360529 CA5666419 |
95 | N>D | No |
ClinGen ExAC gnomAD |
|
|
COSM3709812 rs1489319647 CA377894427 |
95 | N>K | upper_aerodigestive_tract [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
rs1312877941 CA377894422 |
96 | L>P | No |
ClinGen TOPMed |
|
|
rs778210426 CA5666417 |
98 | P>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA377894392 rs1372823774 |
100 | S>R | No |
ClinGen TOPMed |
|
|
CA5666414 rs765147212 |
102 | G>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs765147212 CA5666415 |
102 | G>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs866832946 CA212227099 |
103 | V>I | No |
ClinGen TOPMed gnomAD |
|
|
rs937111635 CA212227090 |
104 | Q>R | No |
ClinGen TOPMed |
|
|
CA5666411 rs766172061 |
105 | G>A | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 107 | V>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA212227080 rs925681686 |
107 | V>L | No |
ClinGen TOPMed gnomAD |
|
|
CA377894356 rs925681686 |
107 | V>M | No |
ClinGen TOPMed gnomAD |
|
|
rs1269515143 CA377894316 |
110 | S>F | No |
ClinGen gnomAD |
|
|
CA5666410 rs760292513 |
112 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA377894279 rs1457596695 |
113 | P>R | No |
ClinGen gnomAD |
|
|
CA377894257 rs1204903350 |
115 | Q>R | No |
ClinGen TOPMed |
|
|
rs550946332 CA377894244 |
116 | R>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs550946332 CA5666408 |
116 | R>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
COSM1345484 CA5666409 rs199625253 |
116 | R>W | large_intestine [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD |
|
CA377894237 rs1411197116 |
117 | P>S | No |
ClinGen gnomAD |
|
|
rs773939359 CA5666406 COSM914230 |
118 | E>K | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
rs1265008423 CA377894199 |
119 | M>I | No |
ClinGen gnomAD |
|
|
rs746151781 CA5666404 |
121 | K>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 122 | E>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1173543120 CA377894164 |
122 | E>K | No |
ClinGen TOPMed |
|
| TCGA novel | 123 | E>missing | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 125 | R>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA212227035 rs931238803 |
126 | S>A | No |
ClinGen TOPMed |
|
|
CA377894092 rs1589906652 |
126 | S>F | No |
ClinGen Ensembl |
|
|
CA5666402 COSM1345483 rs200550064 |
127 | S>L | large_intestine [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD |
|
rs777978639 CA5666400 |
128 | A>G | No |
ClinGen ExAC gnomAD |
|
|
rs772229582 CA5666399 |
129 | A>T | No |
ClinGen ExAC gnomAD |
|
|
rs11550025 CA5666398 |
130 | A>V | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1333266376 CA377894037 |
131 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
rs1299659362 CA377894032 |
132 | A>T | No |
ClinGen gnomAD |
|
|
CA5666397 rs779214216 |
133 | D>H | No |
ClinGen ExAC gnomAD |
|
|
CA212227015 rs938032117 |
134 | T>S | No |
ClinGen TOPMed |
|
|
rs753564983 CA5666395 |
135 | Q>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA212227011 rs952853667 |
136 | D>N | No |
ClinGen TOPMed gnomAD |
|
|
rs756772425 CA5666370 |
138 | A>T | No |
ClinGen ExAC gnomAD |
|
|
rs558605609 CA5666369 |
139 | T>A | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA5666365 rs540496869 |
141 | A>G | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs752346792 CA5666366 |
141 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1277233276 CA377893882 |
142 | E>Q | No |
ClinGen gnomAD |
|
|
rs1226589365 CA377893875 |
143 | E>K | No |
ClinGen gnomAD |
|
|
CA5666363 rs376316530 |
147 | P>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA377893799 rs1333644495 |
149 | V>L | No |
ClinGen TOPMed |
|
| TCGA novel | 149 | V>W | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA212226888 rs373178334 |
150 | D>E | No |
ClinGen Ensembl |
|
|
rs1333503744 CA377893611 |
160 | S>L | No |
ClinGen TOPMed gnomAD |
|
|
CA377893592 rs1372267586 |
161 | V>A | No |
ClinGen gnomAD |
|
|
CA5666360 rs750743278 |
162 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA377893570 rs1565236420 |
163 | Q>K | No |
ClinGen Ensembl |
|
|
rs1242087820 CA377893478 |
166 | W>* | No |
ClinGen TOPMed |
|
|
rs774261229 CA377893466 CA5666359 |
167 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 167 | V>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs200060563 CA377893378 |
172 | R>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA5666358 rs200060563 |
172 | R>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA377893382 rs1414116084 |
172 | R>W | No |
ClinGen TOPMed gnomAD |
|
|
CA212226852 rs943983004 |
174 | D>G | No |
ClinGen TOPMed gnomAD |
|
|
rs1367391809 CA377893356 |
174 | D>H | No |
ClinGen gnomAD |
|
|
CA377893305 rs1589906463 |
177 | E>A | No |
ClinGen Ensembl |
|
|
rs749490513 CA5666357 |
177 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs373873420 CA5666356 |
179 | V>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1203505505 CA377893279 |
179 | V>M | No |
ClinGen gnomAD |
|
|
CA377893234 rs1317522671 |
181 | M>I | No |
ClinGen TOPMed |
|
|
rs1290932807 CA377893189 |
183 | V>A | No |
ClinGen gnomAD |
|
|
CA377893153 rs1230235613 |
185 | G>E | No |
ClinGen gnomAD |
|
|
CA5666355 rs769481024 |
186 | K>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA377893129 rs1416566612 |
186 | K>R | No |
ClinGen TOPMed |
|
|
CA5666354 rs745603729 |
188 | E>A | No |
ClinGen ExAC gnomAD |
|
|
rs757181226 CA5666352 |
190 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs781162377 CA5666353 |
190 | P>S | No |
ClinGen ExAC gnomAD |
|
|
rs911122941 CA212226825 |
192 | A>V | No |
ClinGen Ensembl |
|
|
CA5666350 rs554802882 |
194 | E>Q | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA377892944 rs1280976564 |
196 | P>R | No |
ClinGen TOPMed |
|
| TCGA novel | 198 | Q>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA5666347 rs764890783 |
198 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
CA377892804 rs1565236314 |
201 | P>H | No |
ClinGen Ensembl |
|
|
rs200977019 CA5666329 |
201 | P>S | No |
ClinGen ExAC gnomAD |
|
|
CA5666327 rs369567008 |
202 | R>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA5666326 rs190809867 |
203 | R>C | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1189437681 CA377892774 |
203 | R>H | No |
ClinGen gnomAD |
|
|
rs768014435 CA5666325 |
205 | R>S | No |
ClinGen ExAC gnomAD |
|
|
rs752010575 CA5666323 |
212 | L>M | No |
ClinGen ExAC gnomAD |
|
|
CA377892656 rs1349503864 |
212 | L>R | No |
ClinGen TOPMed |
|
|
CA377892620 rs1217316146 COSM3709811 |
214 | S>F | upper_aerodigestive_tract [Cosmic] | No |
ClinGen cosmic curated gnomAD |
| TCGA novel | 217 | L>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 221 | M>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA5666304 rs779781998 |
221 | M>L | No |
ClinGen ExAC gnomAD |
|
|
rs943843959 CA212226602 |
222 | M>V | No |
ClinGen Ensembl |
|
|
CA5666303 rs757705358 |
225 | S>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA377892343 rs751938662 |
225 | S>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA377892333 rs778209755 |
226 | A>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs778209755 CA5666301 |
226 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs17855346 CA212226599 |
227 | E>* | No |
ClinGen Ensembl |
|
|
CA5666300 rs758905502 |
227 | E>D | No |
ClinGen ExAC gnomAD |
|
|
rs528715219 CA5666299 |
228 | D>N | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1375308789 CA377892201 |
233 | R>Q | No |
ClinGen gnomAD |
|
|
rs1050066028 CA212226590 |
233 | R>W | No |
ClinGen TOPMed |
|
|
CA5666297 rs759545898 |
235 | M>V | No |
ClinGen ExAC gnomAD |
|
|
rs766578679 CA5666295 |
239 | E>K | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 241 | P>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA5666285 rs769482884 |
242 | K>R | No |
ClinGen ExAC gnomAD |
|
|
CA377891920 rs1162914828 |
246 | R>* | Variant assessed as Somatic; 4.638e-05 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA377891917 rs1474902376 |
246 | R>Q | No |
ClinGen gnomAD |
|
|
CA5666283 COSM3414640 rs778175495 |
249 | D>N | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
| TCGA novel | 252 | V>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA5666282 rs758652096 |
252 | V>I | No |
ClinGen ExAC gnomAD |
|
|
CA377891772 rs1210151890 |
254 | S>G | No |
ClinGen TOPMed gnomAD |
|
|
CA377891726 rs1228804807 |
257 | G>A | No |
ClinGen Ensembl |
|
|
rs755109440 CA5666279 |
259 | R>* | No |
ClinGen ExAC gnomAD |
|
|
rs1329226102 CA377891679 |
261 | K>Q | No |
ClinGen gnomAD |
|
|
CA5666277 rs372005158 |
264 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA5666278 rs753914938 |
264 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1589906067 CA377891605 |
265 | N>T | No |
ClinGen Ensembl |
|
|
rs750565558 CA5666275 |
266 | P>R | No |
ClinGen ExAC gnomAD |
|
|
rs760931357 CA5666276 |
266 | P>S | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 268 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA5666273 rs761445800 |
269 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs774440274 CA5666272 |
270 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
rs762618761 CA5666270 |
271 | M>R | No |
ClinGen ExAC gnomAD |
|
|
rs775108901 CA5666269 |
272 | K>E | No |
ClinGen ExAC gnomAD |
|
|
CA377891427 rs1451559593 |
275 | Y>D | No |
ClinGen gnomAD |
|
|
CA377891360 rs1565236123 |
278 | L>F | No |
ClinGen Ensembl |
|
|
CA377891290 rs1363106206 |
282 | R>K | No |
ClinGen gnomAD |
|
|
rs745555678 CA5666267 |
285 | R>C | No |
ClinGen ExAC gnomAD |
|
|
CA5666266 rs776083598 |
285 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
| TCGA novel | 286 | F>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 288 | H>= | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
1 associated diseases with Q9H467
Without disease ID
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nuclear membrane | Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| ubiquitin binding | Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of cytokine production involved in inflammatory response | Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response. |
| negative regulation of macrophage cytokine production | Any process that decreases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MELERIVSAA | LLAFVQTHLP | EADLSGLDEV | IFSYVLGVLE | DLGPSGPSEE | NFDMEAFTEM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| MEAYVPGFAH | IPRGTIGDMM | QKLSGQLSDA | RNKENLQPQS | SGVQGQVPIS | PEPLQRPEML |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KEETRSSAAA | AADTQDEATG | AEEELLPGVD | VLLEVFPTCS | VEQAQWVLAK | ARGDLEEAVQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MLVEGKEEGP | AAWEGPNQDL | PRRLRGPQKD | ELKSFILQKY | MMVDSAEDQK | IHRPMAPKEA |
| 250 | 260 | 270 | 280 | ||
| PKKLIRYIDN | QVVSTKGERF | KDVRNPEAEE | MKATYINLKP | ARKYRFH |