A1L131

PR
Gene name
Cuedc2
Protein name
CUE domain-containing protein 2
Names
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:294009
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

59-147 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A1L131

Entry ID Method Resolution Chain Position Source
AF-A1L131-F1 Predicted AlphaFoldDB

No variants for A1L131

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A1L131

No associated diseases with A1L131

2 regional properties for A1L131

Type Name Position InterPro Accession
domain Ubiquitin system component CUE 124 - 167 IPR003892
domain CUE domain-containing protein 2, CUE domain 126 - 166 IPR039805

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nuclear membrane Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.

1 GO annotations of molecular function

Name Definition
ubiquitin binding Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.

2 GO annotations of biological process

Name Definition
negative regulation of cytokine production involved in inflammatory response Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response.
negative regulation of macrophage cytokine production Any process that decreases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3ZBN4 CUEDC2 CUE domain-containing protein 2 Bos taurus (Bovine) PR
Q9H467 CUEDC2 CUE domain-containing protein 2 Homo sapiens (Human) PR
Q9CXX9 Cuedc2 CUE domain-containing protein 2 Mus musculus (Mouse) PR
10 20 30 40 50 60
MELERIVSSA LFAFVQTHLP EADLSGLDEV IFSYVLGVLE DLGPSGPSEE NFDMEAFIEM
70 80 90 100 110 120
MEAYVPGFAH IHRGIIEDMV QTLSVQLSSA RNKETLRRPE KLKEESRPPA ATGNTQDEAA
130 140 150 160 170 180
AAEEEQPGVD VLLEVFPTCS MEQAQWVLAK ARGNLEEAVQ MLIEGKEEGP PGWGGPNQDL
190 200 210 220 230 240
PRRLRGPRKE ELKSFILQKY MMVDRAEDQK THRPMAPKEA PKKLIRYIDN QVVSTKGERF
250 260
KDVRNPETEE MKATYINLKP ARKYRFH