Q9CXX9

PR
Gene name
Cuedc2
Protein name
CUE domain-containing protein 2
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:67116
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

61-226 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9CXX9

Entry ID Method Resolution Chain Position Source
AF-Q9CXX9-F1 Predicted AlphaFoldDB

14 variants for Q9CXX9

Variant ID(s) Position Change Description Diseaes Association Provenance
rs13474484 13 T>A No EVA
rs3408171137 34 Y>S No EVA
rs3389546235 55 E>V No EVA
rs47481773 114 P>L No EVA
rs3389510044 119 K>R No EVA
rs230719017 147 D>N No EVA
rs3409123846 155 T>A No EVA
rs3413037235 158 M>I No EVA
rs237788701 186 G>R No EVA
rs3389553663 209 L>* No EVA
rs3389499988 234 P>T No EVA
rs3389548800 239 K>M No EVA
rs3389548808 274 N>I No EVA
rs3389537803 276 K>T No EVA

No associated diseases with Q9CXX9

2 regional properties for Q9CXX9

Type Name Position InterPro Accession
domain Ubiquitin system component CUE 141 - 184 IPR003892
domain CUE domain-containing protein 2, CUE domain 144 - 183 IPR039805

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nuclear membrane Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.

1 GO annotations of molecular function

Name Definition
ubiquitin binding Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.

2 GO annotations of biological process

Name Definition
negative regulation of cytokine production involved in inflammatory response Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response.
negative regulation of macrophage cytokine production Any process that decreases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3ZBN4 CUEDC2 CUE domain-containing protein 2 Bos taurus (Bovine) PR
Q9H467 CUEDC2 CUE domain-containing protein 2 Homo sapiens (Human) PR
A1L131 Cuedc2 CUE domain-containing protein 2 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MELERIVGSA LLTFVQAHLP EADLSGLDEV IFSYVLGVLE DLGPSGPSEE NFDMEAFTEM
70 80 90 100 110 120
MEAYVPGFAH IPRGIIGDMM QKLSVQLSDA RNKENLHPQS SCVQGQVPIF PETPRQAEKL
130 140 150 160 170 180
EEESRPPAAP GNTLDEAAAA EELPGVDVLL EVFPTCSMEQ AQWVLAKARG DLEEAVHMLV
190 200 210 220 230 240
EGKEEGPPGW DGPSQDLPRR LRGPQKDDLK SFILQKYMMV DRAEDQKTHR PMAPKEAPKK
250 260 270 280
LIRYIDNQVV STKGERFKDV RNPEAEEMKA TYINLKPARK YRFH