Q3ZBN4

PR
Gene name
CUEDC2
Protein name
CUE domain-containing protein 2
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:516091
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

61-161 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3ZBN4

Entry ID Method Resolution Chain Position Source
AF-Q3ZBN4-F1 Predicted AlphaFoldDB

14 variants for Q3ZBN4

Variant ID(s) Position Change Description Diseaes Association Provenance
rs440896650 22 A>D No EVA
rs436385407 27 L>F No EVA
rs474258559 28 D>G No EVA
rs386064197 175 A>V No EVA
rs876394065 195 D>A No EVA
rs876623684 210 S>P No EVA
rs434100424 220 D>G No EVA
rs465929086 224 D>G No EVA
rs445884093 227 I>F No EVA
rs432225620 228 H>D No EVA
rs470106284 235 E>K No EVA
rs452284179 237 P>H No EVA
rs432144637 238 K>Q No EVA
rs470015242 245 D>E No EVA

No associated diseases with Q3ZBN4

2 regional properties for Q3ZBN4

Type Name Position InterPro Accession
domain Ubiquitin system component CUE 141 - 184 IPR003892
domain CUE domain-containing protein 2, CUE domain 144 - 183 IPR039805

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nuclear membrane Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.

1 GO annotations of molecular function

Name Definition
ubiquitin binding Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.

2 GO annotations of biological process

Name Definition
negative regulation of cytokine production involved in inflammatory response Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response.
negative regulation of macrophage cytokine production Any process that decreases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9H467 CUEDC2 CUE domain-containing protein 2 Homo sapiens (Human) PR
Q9CXX9 Cuedc2 CUE domain-containing protein 2 Mus musculus (Mouse) PR
A1L131 Cuedc2 CUE domain-containing protein 2 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MELERIVSAA LLAFVQTHLP EADLSGLDDV IFSYVLGVLG DLGPSGPSEE NFDMEAFTEM
70 80 90 100 110 120
MEAYVPGFAH IPRGTIGDMI QKLSGQLSGA RNKENVQPQS SEVQGQVSIS PEPLQRPEKL
130 140 150 160 170 180
KEETMSSAGD TQDEAAGPEE ELLPGVDVLL EVFPTCSVEQ AQWVLAKARG DLEEAVQMLV
190 200 210 220 230 240
EGKQGPPAWD GPNQDLPRRL RGPQKDELKS FILQKYMMVD SAEDQKIHRP MAPKEAPKKL
250 260 270 280
IRYIDNQIVS TKGERFKDVR NPEAEEMKAT YINLKPARKY RFH