Q9FI53
PR
Gene name |
FUM2 |
Protein name |
Fumarate hydratase 2 |
Names |
AtFUM2, Fumarase 2 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G50950 |
EC number |
4.2.1.2: Hydro-lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9FI53
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9FI53-F1 | Predicted | AlphaFoldDB |
38 variants for Q9FI53
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH03407109 | 2 | A>S | No | 1000Genomes | |
| ENSVATH07392473 | 6 | M>T | No | 1000Genomes | |
| tmp_5_20729714_G_A | 10 | G>R | No | 1000Genomes | |
| ENSVATH12692033 | 10 | G>V | No | 1000Genomes | |
| ENSVATH03407110 | 12 | K>M | No | 1000Genomes | |
| ENSVATH03407111 | 13 | K>I | No | 1000Genomes | |
| ENSVATH07392474 | 17 | E>K | No | 1000Genomes | |
| tmp_5_20729750_A_T | 22 | T>S | No | 1000Genomes | |
| tmp_5_20729793_C_T | 36 | S>L | No | 1000Genomes | |
| ENSVATH12692034 | 37 | T>S | No | 1000Genomes | |
| ENSVATH03407112 | 48 | P>Q | No | 1000Genomes | |
| ENSVATH00725615 | 49 | I>V | No | 1000Genomes | |
| tmp_5_20729963_C_A | 65 | L>I | No | 1000Genomes | |
| tmp_5_20730005_G_A | 79 | E>K | No | 1000Genomes | |
| tmp_5_20730225_C_A | 126 | P>H | No | 1000Genomes | |
| tmp_5_20730948_C_T | 158 | R>C | No | 1000Genomes | |
| tmp_5_20731219_C_T | 192 | T>I | No | 1000Genomes | |
| ENSVATH07392484 | 197 | P>S | No | 1000Genomes | |
| tmp_5_20731243_A_G | 200 | K>R | No | 1000Genomes | |
| tmp_5_20731246_A_T | 201 | N>I | No | 1000Genomes | |
| ENSVATH12692102 | 204 | S>C | No | 1000Genomes | |
| ENSVATH00725624 | 207 | E>A | No | 1000Genomes | |
| ENSVATH14624178 | 237 | G>D | No | 1000Genomes | |
| ENSVATH00725625 | 244 | E>K | Plants were checked bi-weekly for presence of first buds and the average flowering time of 4 plants of the same accession were collected [16c and 16 hrs daylight] [EnsemblGenome] | No | 1000Genomes |
| tmp_5_20731742_T_A | 245 | Y>N | No | 1000Genomes | |
| tmp_5_20731904_G_C | 270 | G>R | No | 1000Genomes | |
| tmp_5_20732466_G_C | 339 | C>S | No | 1000Genomes | |
| ENSVATH07392503 | 341 | L>F | No | 1000Genomes | |
| ENSVATH03407165 | 376 | M>I | No | 1000Genomes | |
| tmp_5_20732807_G_A | 382 | V>M | No | 1000Genomes | |
| ENSVATH14624195 | 408 | I>V | No | 1000Genomes | |
| ENSVATH07392507 | 427 | E>V | No | 1000Genomes | |
| tmp_5_20733055_A_C | 435 | K>T | No | 1000Genomes | |
| ENSVATH12692203 | 438 | H>Y | No | 1000Genomes | |
| ENSVATH14624198 | 453 | Y>N | No | 1000Genomes | |
| ENSVATH07392514 | 490 | V>I | No | 1000Genomes | |
| tmp_5_20733608_C_A | 491 | P>H | No | 1000Genomes | |
| ENSVATH12692225 | 499 | D>N | No | 1000Genomes |
No associated diseases with Q9FI53
Functions
| Description | ||
|---|---|---|
| EC Number | 4.2.1.2 | Hydro-lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| plastid | Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. |
| tricarboxylic acid cycle enzyme complex | Any of the heteromeric enzymes that act in the TCA cycle. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| fumarate hydratase activity | Catalysis of the reaction: (S)-malate = fumarate + H(2)O. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| cold acclimation | Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures. |
| fumarate metabolic process | The chemical reactions and pathways involving fumarate, the anion of trans-1,2-ethenedicarboxylic acid, the diastereoisomer of maleate. It is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate. |
| malate metabolic process | The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. |
| nitrate assimilation | The nitrogen metabolic process that encompasses the uptake of nitrate from the environment and reduction to ammonia, and results in the incorporation of nitrogen derived from nitrate into cellular substances. |
| protein tetramerization | The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits. |
| regulation of photosynthesis | Any process that modulates the frequency, rate or extent of photosynthesis. |
| tricarboxylic acid cycle | A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P07954 | FH | Fumarate hydratase, mitochondrial | Homo sapiens (Human) | PR |
| P97807 | Fh | Fumarate hydratase, mitochondrial | Mus musculus (Mouse) | PR |
| P14408 | Fh | Fumarate hydratase, mitochondrial | Rattus norvegicus (Rat) | PR |
| O17214 | fum-1 | Probable fumarate hydratase, mitochondrial | Caenorhabditis elegans | PR |
| Q7SX99 | fh | Fumarate hydratase, mitochondrial | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAALTMQFEG | EKKNVSEVAD | VTLKQEDEQQ | ERRSYSTPFR | EERDTFGPIQ | VPSDKLWGAQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TQRSLQNFEI | GGDRERMPEP | IVRAFGVLKK | CAAKVNMEYG | LDPMIGEAIM | EAAQEVAEGK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LNDHFPLVVW | QTGSGTQSNM | NANEVIANRA | AEILGHKRGE | KIVHPNDHVN | RSQSSNDTFP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TVMHIAAATE | ITSRLIPSLK | NLHSSLESKS | FEFKDIVKIG | RTHTQDATPL | TLGQEFGGYA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TQVEYGLNRV | ACTLPRIYQL | AQGGTAVGTG | LNTKKGFDVK | IAAAVAEETN | LPFVTAENKF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EALAAHDACV | ETSGSLNTIA | TSLMKIANDI | RFLGSGPRCG | LGELSLPENE | PGSSIMPGKV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NPTQCEALTM | VCAQVMGNHV | AVTIGGSNGH | FELNVFKPVI | ASALLHSIRL | IADASASFEK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NCVRGIEANR | ERISKLLHES | LMLVTSLNPK | IGYDNAAAVA | KRAHKEGCTL | KHAAMKLGVL |
| 490 | |||||
| TSEEFDTLVV | PEKMIGPSD |