P97807

PR
Gene name
Fh
Protein name
Fumarate hydratase, mitochondrial
Names
Fumarase, EF-3
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:14194
EC number
4.2.1.2: Hydro-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-77 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P97807

Entry ID Method Resolution Chain Position Source
AF-P97807-F1 Predicted AlphaFoldDB

18 variants for P97807

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388520523 106 E>K No EVA
rs3388519164 107 Y>C No EVA
rs3388521695 157 R>I No EVA
rs3388518823 245 F>V No EVA
rs32536342 296 A>T No EVA
rs3390976665 329 A>G No EVA
rs3390999665 330 C>G No EVA
rs3391073154 335 I>K No EVA
rs3391034051 335 I>V No EVA
rs3388519407 385 M>S No EVA
rs3388519964 394 G>R No EVA
rs3388518820 401 E>V No EVA
rs32532753 429 D>E No EVA
rs3388514610 459 H>Y No EVA
rs3388516736 472 A>V No EVA
rs3388517285 483 A>D No EVA
rs3388520585 484 I>F No EVA
rs3388519234 491 A>T No EVA

No associated diseases with P97807

3 regional properties for P97807

Type Name Position InterPro Accession
domain Fumarase C, C-terminal 452 - 504 IPR018951
conserved_site Fumarate lyase, conserved site 361 - 370 IPR020557
domain Fumarate lyase, N-terminal 55 - 386 IPR022761

Functions

Description
EC Number 4.2.1.2 Hydro-lyases
Subcellular Localization
  • [Isoform Mitochondrial]: Mitochondrion
  • ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
site of double-strand break A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.
tricarboxylic acid cycle enzyme complex Any of the heteromeric enzymes that act in the TCA cycle.

2 GO annotations of molecular function

Name Definition
fumarate hydratase activity Catalysis of the reaction: (S)-malate = fumarate + H(2)O.
histone binding Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.

11 GO annotations of biological process

Name Definition
cellular response to DNA damage stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
fumarate metabolic process The chemical reactions and pathways involving fumarate, the anion of trans-1,2-ethenedicarboxylic acid, the diastereoisomer of maleate. It is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate.
homeostasis of number of cells within a tissue Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue.
malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle.
negative regulation of histone H3-K36 methylation Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3.
positive regulation of cold-induced thermogenesis Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
positive regulation of double-strand break repair via nonhomologous end joining Any process that activates or increases the frequency, rate or extent of double-strand break repair via nonhomologous end joining.
regulation of arginine metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid.
tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
urea cycle The sequence of reactions by which arginine is synthesized from ornithine, then cleaved to yield urea and regenerate ornithine. The overall reaction equation is NH3 + CO2 + aspartate + 3 ATP + 2 H2O = urea + fumarate + 2 ADP + 2 phosphate + AMP + diphosphate.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P07954 FH Fumarate hydratase, mitochondrial Homo sapiens (Human) PR
P14408 Fh Fumarate hydratase, mitochondrial Rattus norvegicus (Rat) PR
O17214 fum-1 Probable fumarate hydratase, mitochondrial Caenorhabditis elegans PR
Q9FI53 FUM2 Fumarate hydratase 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q7SX99 fh Fumarate hydratase, mitochondrial Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MYRALRLLAR SRRLLRVPSA GAAVSGEATT LPRCAPNVAR MASQNSFRVE FDTFGELKVP
70 80 90 100 110 120
TDKYYGAQTV RSTMNFKIGG ATERMPIPVI QAFGILKRAA AEVNQEYGLD PKIASAIMKA
130 140 150 160 170 180
ADEVAEGKLN DHFPLVVWQT GSGTQTNMNV NEVISNRAIE MLGGELGSKK PVHPNDHVNK
190 200 210 220 230 240
SQSSNDTFPT AMHIAAAVEV HKVLLPGLQK LHDALSAKSK EFAQVIKIGR THTQDAVPLT
250 260 270 280 290 300
LGQEFSGYVQ QVQYAMVRIK AAMPRIYELA AGGTAVGTGL NTRIGFAEKV AAKVAALTGL
310 320 330 340 350 360
PFVTAPNKFE ALAAHDALVE LSGAMNTAAC SLMKIANDIR FLGSGPRSGL GELILPENEP
370 380 390 400 410 420
GSSIMPGKVN PTQCEAMTMV AAQVMGNHVA VTVGGSNGHF ELNVFKPMMI KNVLHSARLL
430 440 450 460 470 480
GDASVSFTDN CVVGIQANTE RINKLMNESL MLVTALNPHI GYDKAAKIAK TAHKNGSTLK
490 500
ETAIELGYLT AEQFDEWVKP KDMLGPK