O17214
Gene name |
fum-1 |
Protein name |
Probable fumarate hydratase, mitochondrial |
Names |
Fumarase |
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_H14A12.2 |
EC number |
4.2.1.2: Hydro-lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O17214
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O17214-F1 | Predicted | AlphaFoldDB |
No variants for O17214
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O17214 | |||||
No associated diseases with O17214
Functions
| Description | ||
|---|---|---|
| EC Number | 4.2.1.2 | Hydro-lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrial matrix | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| tricarboxylic acid cycle enzyme complex | Any of the heteromeric enzymes that act in the TCA cycle. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| fumarate hydratase activity | Catalysis of the reaction: (S)-malate = fumarate + H(2)O. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| fumarate metabolic process | The chemical reactions and pathways involving fumarate, the anion of trans-1,2-ethenedicarboxylic acid, the diastereoisomer of maleate. It is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate. |
| malate metabolic process | The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. |
| tricarboxylic acid cycle | A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P07954 | FH | Fumarate hydratase, mitochondrial | Homo sapiens (Human) | PR |
| P97807 | Fh | Fumarate hydratase, mitochondrial | Mus musculus (Mouse) | PR |
| P14408 | Fh | Fumarate hydratase, mitochondrial | Rattus norvegicus (Rat) | PR |
| Q9FI53 | FUM2 | Fumarate hydratase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q7SX99 | fh | Fumarate hydratase, mitochondrial | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSAVSMLQGE | MLARGGAVIA | RGASLATARN | FSRTTVPMAK | IRKERDTFGE | LEVPADKYYG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AQTARSQMNF | KIGGPEERMP | IPVIHAFGIL | KKAAALVNTE | FGLDKKLADA | ISQAADEVVD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GKLDEHFPLV | TWQTGSGTQS | NMNVNEVISN | RAIEILGGEL | GSKKPVHPND | HVNMSQSSND |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TFPTAMHIAV | GREVNSRLLP | ALKKLRTALH | NKAEEFKDII | KIGRTHTQDA | VPLTLGQEFS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AYVTQLDNSI | ARVESTLPRL | YQLAAGGTAV | GTGLNTRKGF | AEKVAATVSE | LTGLPFVTAP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NKFEALAAHD | ALVEVHGALN | TVAVSFMKIG | NDIRFLGSGP | RCGLGELSLP | ENEPGSSIMP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GKVNPTQCEA | ITMVAAQVMG | NQVAVSVGGS | NGHFELNVFK | PLIVRNVLQS | TRLLADSAVS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FTDHCVDGIV | ANKDNIAKIM | RESLMLVTAL | NPHIGYDNAA | KIAKTAHKNG | TTLVQEAVKL |
| 490 | 500 | ||||
| GILTEEQFAQ | WVKPENMLGP | K |