Q9EPK6

PR
Gene name
Sil1
Protein name
Nucleotide exchange factor SIL1
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:81500
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

104-181 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9EPK6

Entry ID Method Resolution Chain Position Source
AF-Q9EPK6-F1 Predicted AlphaFoldDB

26 variants for Q9EPK6

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389495697 3 P>S No EVA
rs3389507212 7 P>A No EVA
rs3389494536 9 T>I No EVA
rs246751756 13 S>F No EVA
rs3407764166 45 K>N No EVA
rs3389442711 64 T>VSDG* No EVA
rs3389502490 68 E>G No EVA
rs3389502490 68 E>V No EVA
rs3389494136 96 Q>E No EVA
rs3389502441 187 Q>* No EVA
rs3389494501 199 S>T No EVA
rs3389494473 201 S>F No EVA
rs3389487149 205 E>* No EVA
rs3389452972 236 I>V No EVA
rs3389498423 253 V>L No EVA
rs3408322562 254 L>R No EVA
rs3408461896 254 L>V No EVA
rs13475362 295 F>L No EVA
rs3389452974 325 Q>H No EVA
rs3389495654 373 L>F No EVA
rs3389498430 398 R>L No EVA
rs3389487675 404 T>A No EVA
rs3389498402 421 Q>L No EVA
rs31813717 446 D>V No EVA
rs3389489113 449 Y>C No EVA
rs3389495629 463 E>* No EVA

No associated diseases with Q9EPK6

3 regional properties for Q9EPK6

Type Name Position InterPro Accession
domain Folliculin, DENN domain 345 - 566 IPR032035
domain Folliculin/SMCR8, longin domain 105 - 265 IPR037520
domain Folliculin/SMCR8, tripartite DENN domain 86 - 558 IPR037521

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum lumen
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum lumen The volume enclosed by the membranes of the endoplasmic reticulum.

2 GO annotations of molecular function

Name Definition
adenyl-nucleotide exchange factor activity Binds to and stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins.
identical protein binding Binding to an identical protein or proteins.

1 GO annotations of biological process

Name Definition
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P38260 FES1 Hsp70 nucleotide exchange factor FES1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q32KV6 SIL1 Nucleotide exchange factor SIL1 Bos taurus (Bovine) PR
Q9H173 SIL1 Nucleotide exchange factor SIL1 Homo sapiens (Human) PR
Q6P6S4 Sil1 Nucleotide exchange factor SIL1 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MAPQHLPSTR MASPGMLLGL LLTSCLTLCL SCQNSNNFAL TNPEKSIHQE SDTKETREEE
70 80 90 100 110 120
ELDTEILEVF HPTQEWQTLQ PGQAVPAGSH VRMNLQTGVN EVKLQQEDKF QNNLKGFKRG
130 140 150 160 170 180
RRLDINANTY TSQDLKSALA KFKEGTEMEN SKDELARQAT VKQLFRPIEE LKKEFDELNV
190 200 210 220 230 240
VLETDMQIMV RLINKFNSSS SSLEEKVAAL FDLEYYVHQM DNAQDLLSFG GLQVVINGLN
250 260 270 280 290 300
STEPLVKEYA AFVLGAAFSS NPKVQVEAIE GGALQKLLVI LATNQPLPAK KKVLFALCSL
310 320 330 340 350 360
LRHFPYAQQQ FLKLGGLQVL RSLVQEKSAK VLAVRVVTLL YDLVTEKMFA EEEAELTQDS
370 380 390 400 410 420
SPEKLQQYRQ VQLLPGLQEQ GWCEITAQLL ALPEHDAREK VLQTLGALLT TCRDRYRQDL
430 440 450 460
QLSRTLGRLQ AEYQALASLE LQEGEDDGYF RELLASINSL MKELR