Q6P6S4
Gene name |
Sil1 |
Protein name |
Nucleotide exchange factor SIL1 |
Names |
|
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:291673 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6P6S4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6P6S4-F1 | Predicted | AlphaFoldDB |
No variants for Q6P6S4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6P6S4 | |||||
No associated diseases with Q6P6S4
5 regional properties for Q6P6S4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Phenylalanyl-tRNA synthetase | 210 - 483 | IPR002319 |
| domain | Aminoacyl-tRNA synthetase, class II | 229 - 491 | IPR006195 |
| domain | PheRS DNA binding domain 2 | 134 - 165 | IPR040586 |
| domain | PheRS, DNA binding domain 1 | 3 - 61 | IPR040724 |
| domain | PheRS, DNA binding domain 3 | 75 - 132 | IPR040725 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum lumen | The volume enclosed by the membranes of the endoplasmic reticulum. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| adenyl-nucleotide exchange factor activity | Binds to and stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins. |
| identical protein binding | Binding to an identical protein or proteins. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P38260 | FES1 | Hsp70 nucleotide exchange factor FES1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q32KV6 | SIL1 | Nucleotide exchange factor SIL1 | Bos taurus (Bovine) | PR |
| Q9H173 | SIL1 | Nucleotide exchange factor SIL1 | Homo sapiens (Human) | PR |
| Q9EPK6 | Sil1 | Nucleotide exchange factor SIL1 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAPQHLPSTR | MAPQGMLLGL | LLASCLTFCL | SCQNSNNFAL | TNPEKSTHED | SDTKETRREE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ELDAEVLEVL | NPTQEWQALQ | PGQAVPAGSH | VRMNLQTGVN | EVKLQQEDKF | QSNWKGFKRG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RRLDINTNTY | TSQDLKSALA | KFKEGTEMEN | SKDELARQAT | VKQLFRPIEE | LKKEFDELNV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VLETDMQIMV | RLINKFNSSS | SSLEEKVAAL | FDLEYYVHQM | DNAQDLLSFG | GLQVVINGLN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| STEPLVKEYA | AFVLGAAFSS | NPKVQVEAIE | GGALQKLLVI | LATEQPLPAK | KKVLFALCSL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LRHFPYAQQQ | FLKLGGLQVL | RSLVQEKSAK | VLAVRVVTLL | YDLVTEKMFA | EEEAELTQES |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SPEKLQQYRQ | VQLLPGLREQ | GWCEITAQLL | ALPEHDAREK | VLQTLGALLA | TCRDRYRQDL |
| 430 | 440 | 450 | 460 | ||
| ELSRTLGSLQ | AEYQALASLE | LQEGEDDGYF | RELLASIDSL | VKELR |