P38260

PR
Gene name
FES1 (YBR101C, YBR0830)
Protein name
Hsp70 nucleotide exchange factor FES1
Names
Factor exchange for SSA1 protein 1
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YBR101C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-71 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P38260

Entry ID Method Resolution Chain Position Source
AF-P38260-F1 Predicted AlphaFoldDB

5 variants for P38260

Variant ID(s) Position Change Description Diseaes Association Provenance
s02-444672 6 Q>K No SGRP
s02-444169 173 L>F No SGRP
s02-444086 201 T>I No SGRP
s02-443940 250 I>V No SGRP
s02-443906 261 L>S No SGRP

No associated diseases with P38260

No regional properties for P38260

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P38260

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

1 GO annotations of molecular function

Name Definition
adenyl-nucleotide exchange factor activity Binds to and stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins.

2 GO annotations of biological process

Name Definition
cytoplasm protein quality control by the ubiquitin-proteasome system The chemical reactions and pathways resulting in the breakdown of misfolded proteins in the cytoplasm, which are targeted to cytoplasmic proteasomes for degradation.
regulation of translation Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q32KV6 SIL1 Nucleotide exchange factor SIL1 Bos taurus (Bovine) PR
Q9H173 SIL1 Nucleotide exchange factor SIL1 Homo sapiens (Human) PR
Q9EPK6 Sil1 Nucleotide exchange factor SIL1 Mus musculus (Mouse) PR
Q6P6S4 Sil1 Nucleotide exchange factor SIL1 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MEKLLQWSIA NSQGDKEAMA RAGQPDPKLL QQLFGGGGPD DPTLMKESMA VIMNPEVDLE
70 80 90 100 110 120
TKLVAFDNFE MLIENLDNAN NIENLKLWEP LLDVLVQTKD EELRAAALSI IGTAVQNNLD
130 140 150 160 170 180
SQNNFMKYDN GLRSLIEIAS DKTKPLDVRT KAFYALSNLI RNHKDISEKF FKLNGLDCIA
190 200 210 220 230 240
PVLSDNTAKP KLKMRAIALL TAYLSSVKID ENIISVLRKD GVIESTIECL SDESNLNIID
250 260 270 280
RVLSFLSHLI SSGIKFNEQE LHKLNEGYKH IEPLKDRLNE DDYLAVKYVL