Q32KV6

PR
Gene name
SIL1
Protein name
Nucleotide exchange factor SIL1
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:520650
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

14-194 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q32KV6

Entry ID Method Resolution Chain Position Source
AF-Q32KV6-F1 Predicted AlphaFoldDB

94 variants for Q32KV6

Variant ID(s) Position Change Description Diseaes Association Provenance
rs432196447 5 G>V No EVA
rs452965155 6 L>P No EVA
rs436070464 7 L>I No EVA
rs436709513 13 P>L No EVA
rs469553881 14 L>P No EVA
rs477442112 15 C>F No EVA
rs446293750 15 C>S No EVA
rs446972733 16 V>L No EVA
rs481581748 18 L>P No EVA
rs461368389 21 L>V No EVA
rs438711320 29 C>* No EVA
rs458874363 29 C>S No EVA
rs442548585 35 S>A No EVA
rs720755116 103 D>N No EVA
rs136896308 110 N>H No EVA
rs475864355 139 F>L No EVA
rs481637526 155 Q>K No EVA
rs443498517 227 G>S No EVA
rs437528748 230 Q>R No EVA
rs476502338 235 G>E No EVA
rs458597229 258 N>K No EVA
rs479436286 261 V>D No EVA
rs479436286 261 V>G No EVA
rs438502021 261 V>L No EVA
rs459339089 263 V>A No EVA
rs475308148 276 V>D No EVA
rs444613642 277 I>S No EVA
rs456484473 301 F>L No EVA
rs443678888 303 Y>* No EVA
rs478227909 309 L>Q No EVA
rs458126723 310 K>Q No EVA
rs455502597 324 K>T No EVA
rs476393667 331 V>E No EVA
rs464032418 334 V>A No EVA
rs453591182 340 L>P No EVA
rs433507657 341 V>A No EVA
rs466508106 344 K>R No EVA
rs469121551 364 Q>P No EVA
rs432198936 367 Q>H No EVA
rs466785527 368 V>G No EVA
rs446547213 369 H>P No EVA
rs446547213 369 H>R No EVA
rs876016823 370 L>P No EVA
rs481168885 372 P>R No EVA
rs460995501 373 S>T No EVA
rs876537032 380 C>G No EVA
rs450538948 381 E>* No EVA
rs481801629 383 T>P No EVA
rs463279441 385 H>P No EVA
rs439881260 386 L>P No EVA
rs460765600 387 L>R No EVA
rs440548178 390 P>Q No EVA
rs437990018 391 E>D No EVA
rs454840441 391 E>K No EVA
rs475584370 393 D>A No EVA
rs452334424 394 A>S No EVA
rs466786297 398 V>A No EVA
rs466786297 398 V>G No EVA
rs436157081 399 L>P No EVA
rs467504393 401 T>A No EVA
rs467504393 401 T>P No EVA
rs481863160 402 L>R No EVA
rs444754944 403 G>A No EVA
rs460771374 404 A>T No EVA
rs440606885 406 L>M No EVA
rs876139139 406 L>R No EVA
rs875993345 407 A>P No EVA
rs481403462 408 T>N No EVA
rs475681419 408 T>P No EVA
rs461307471 411 D>G No EVA
rs475647836 414 H>Y No EVA
rs452399818 416 D>G No EVA
rs438737489 417 T>K No EVA
rs473350851 418 Q>K No EVA
rs457069969 425 T>S No EVA
rs436901395 427 Q>R No EVA
rs465017789 429 E>K No EVA
rs479421581 433 L>V No EVA
rs467321802 436 L>R No EVA
rs447077011 437 E>D No EVA
rs481468455 438 L>R No EVA
rs461368921 441 G>A No EVA
rs461368921 441 G>V No EVA
rs482126765 442 E>D No EVA
rs456927342 443 D>H No EVA
rs438802328 447 F>C No EVA
rs520707653 448 R>W No EVA
rs453228235 457 L>V No EVA
rs442736103 457 L>W No EVA
rs436964463 458 L>Q No EVA
rs457135171 458 L>V No EVA
rs451281732 459 T>P No EVA
rs434401822 460 E>G No EVA
rs465719512 461 L>M No EVA

No associated diseases with Q32KV6

2 regional properties for Q32KV6

Type Name Position InterPro Accession
conserved_site Polyprenyl synthetase, conserved site 90 - 104 IPR033749-1
conserved_site Polyprenyl synthetase, conserved site 224 - 236 IPR033749-2

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum lumen
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
endoplasmic reticulum lumen The volume enclosed by the membranes of the endoplasmic reticulum.

2 GO annotations of molecular function

Name Definition
adenyl-nucleotide exchange factor activity Binds to and stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins.
identical protein binding Binding to an identical protein or proteins.

1 GO annotations of biological process

Name Definition
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P38260 FES1 Hsp70 nucleotide exchange factor FES1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q9H173 SIL1 Nucleotide exchange factor SIL1 Homo sapiens (Human) PR
Q9EPK6 Sil1 Nucleotide exchange factor SIL1 Mus musculus (Mouse) PR
Q6P6S4 Sil1 Nucleotide exchange factor SIL1 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MPHQGLLLFR MAPLCVLLSM LMVSCFNFCL CHKNSEFALT NPEKSSTKET ERKETEEELE
70 80 90 100 110 120
PKILEVFHPT HEWQALRPGQ AVPAGSHVRL NLQTGAREVK LHDEDKFQTN LKGLKKGKRL
130 140 150 160 170 180
DINTNTYTSQ DLKNALAKFK EGAEMENSKE DQERQAKVKR LFRPIEELKK DFEELNVVIE
190 200 210 220 230 240
TDMQIMVRLI NKFNSSSSSL EEKIAALFDL EYYVHQMDNA QDLLSFGGLQ VVINGLNSTE
250 260 270 280 290 300
PLVKEYAAFV LGAAFSSNPK VQVEAIEGGA LQKLLVILAT EQPLTTKKKA LFALCSLLRH
310 320 330 340 350 360
FPYAQQQFLK LGGLQVLRSL VQEKGMEVLA VRVVTLLYDL VTEKMFAEED AELTWDMSPK
370 380 390 400 410 420
RLQQYRQVHL LPSLQEQGWC EITAHLLALP EHDAREKVLQ TLGALLATCR DRFHQDTQLH
430 440 450 460
RTLGTLQAEY QALAALELQE GEDEGYFREL LDSIDSLLTE LR