AiPD: Autoinhibited Protein Database

Gene name	Dcaf6 (Iqwd1)
Protein name	DDB1- and CUL4-associated factor 6
Names	IQ motif and WD repeat-containing protein 1, Nuclear receptor interaction protein, NRIP
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:74106
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

626-709 (Predicted disordered autoinhibitory region) PR

626-709 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9DC22-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388511434	102	F>L	No	EVA
rs3388511035	134	Q>H	No	EVA
rs864264600	179	K>N	No	EVA
rs3388512844	199	I>N	No	EVA
rs3388509575	201	P>S	No	EVA
rs3388513490	203	V>L	No	EVA
rs3388512808	217	R>Q	No	EVA
rs3390923521	260	C>*	No	EVA
rs3390937104	260	C>Y	No	EVA
rs3388508996	327	S>N	No	EVA
rs3410870026	336	S>N	No	EVA
rs3388509892	351	R>S	No	EVA
rs38212627	379	D>E	No	EVA
rs254202550	405	A>V	No	EVA
rs3390882949	421	Q>K	No	EVA
rs3390926345	421	Q>L	No	EVA
rs37348469	431	R>H	No	EVA
rs237699428	438	C>S	No	EVA
rs216269293	445	Q>H	No	EVA
rs3388515888	456	H>L	No	EVA
rs3388513607	498	W>C	No	EVA
rs3388515900	504	S>T	No	EVA
rs3388514441	512	C>R	No	EVA
rs237283061	525	S>N	No	EVA
rs3388510069	549	P>S	No	EVA
rs3388510087	575	G>*	No	EVA
rs3388509944	575	G>V	No	EVA
rs219179067	577	K>R	No	EVA
rs233069187	582	Q>H	No	EVA
rs217608728	588	L>V	No	EVA
rs259572363	591	E>D	No	EVA
rs235518455	593	T>A	No	EVA
rs3388512089	593	T>I	No	EVA
rs3388513253	594	L>M	No	EVA
rs251582252	596	E>D	No	EVA
rs3388513891	597	T>A	No	EVA
rs225979263	605	A>T	No	EVA
rs3388513285	607	T>I	No	EVA
rs578921928	608	E>D	No	EVA
rs3388509547	609	S>I	No	EVA
rs227201993	616	T>A	No	EVA
rs1134846917	620	L>R	No	EVA
rs3388514111	628	E>*	No	EVA
rs264417328	633	E>D	No	EVA
rs250057831	639	T>A	No	EVA
rs3388513570	639	T>I	No	EVA
rs264517429	641	A>T	No	EVA
rs238036344	642	N>K	No	EVA
rs219213689	645	L>R	No	EVA
rs3388509515	659	D>Y	No	EVA
rs3388512821	701	E>*	No	EVA
rs3388509530	724	L>I	No	EVA
rs3390928719	773	L>P	No	EVA
rs3388509940	816	K>E	No	EVA
rs3388513291	828	M>I	No	EVA
rs3388514504	856	D>G	No	EVA
rs3388513185	874	D>E	No	EVA
rs3388514058	876	E>K	No	EVA

Type	Name	Position	InterPro Accession
binding_site	IQ motif, EF-hand binding site	692 - 719	IPR000048
repeat	WD40 repeat	40 - 79	IPR001680-1
repeat	WD40 repeat	82 - 124	IPR001680-2
repeat	WD40 repeat	130 - 170	IPR001680-3
repeat	WD40 repeat	184 - 220	IPR001680-4
repeat	WD40 repeat	238 - 281	IPR001680-5
repeat	WD40 repeat	722 - 763	IPR001680-6
repeat	WD40 repeat	766 - 805	IPR001680-7

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
Cul4-RING E3 ubiquitin ligase complex	A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
focal adhesion	A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
nuclear receptor coactivator activity	A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator.

Name	Definition
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
protein ubiquitination	The process in which one or more ubiquitin groups are added to a protein.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P0C7V8	DCAF8L2	DDB1- and CUL4-associated factor 8-like protein 2	Homo sapiens (Human)	PR
Q5TAQ9	DCAF8	DDB1- and CUL4-associated factor 8	Homo sapiens (Human)	PR
A6NGE4	DCAF8L1	DDB1- and CUL4-associated factor 8-like protein 1	Homo sapiens (Human)	PR
Q58WW2	DCAF6	DDB1- and CUL4-associated factor 6	Homo sapiens (Human)	PR