AiPD: Autoinhibited Protein Database

P0C7V8

Gene name	DCAF8L2 (WDR42C)
Protein name	DDB1- and CUL4-associated factor 8-like protein 2
Names	WD repeat-containing protein 42C
Species	Homo sapiens (Human)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-224 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-224 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for P0C7V8

Entry ID	Method	Resolution	Chain	Position	Source
AF-P0C7V8-F1	Predicted				AlphaFoldDB

393 variants for P0C7V8

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA10374702 rs767550922	3	H>Q		No	ClinGen ExAC gnomAD
rs759738501 CA10374701	3	H>R		No	ClinGen ExAC TOPMed gnomAD
rs796489879 CA328071119	5	E>Q		No	ClinGen Ensembl
rs1185276555 CA412621148	9	D>N		No	ClinGen TOPMed
CA10374704 rs756619299	10	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1194055831 CA412621178	13	D>G		No	ClinGen TOPMed
CA412621183 rs1448928458	14	L>V		No	ClinGen TOPMed
CA10374705 rs192806500	15	G>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA412621195 rs1326985086	16	T>A		No	ClinGen gnomAD
CA10374706 rs754344752	17	E>A		No	ClinGen ExAC TOPMed gnomAD
rs183301101 CA10374707	18	S>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA412621217 rs1321871420	19	L>R		No	ClinGen gnomAD
CA10374708 rs62623432	20	F>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10374709 rs745571354	23	P>S		No	ClinGen ExAC gnomAD
rs1389391655 CA412621260	25	E>D		No	ClinGen gnomAD
rs1003128073 CA328071120	25	E>K		No	ClinGen TOPMed
TCGA novel	26	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs113826309 CA10374710	30	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs746501868 CA10374712	31	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1266440439 CA412621303	32	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA10374714 rs1569200707	33	T>F		No	ClinGen Ensembl
rs1199443413 CA412621307	33	T>K		No	ClinGen gnomAD
CA328071121 rs941334021	35	A>S		No	ClinGen Ensembl
rs1460438407 CA412621332	37	S>L		No	ClinGen gnomAD
CA412621339 rs1170179213	38	D>G		No	ClinGen gnomAD
rs375379571 CA328071122	39	I>V		No	ClinGen gnomAD
CA412621349 rs1372549063	40	D>N		No	ClinGen gnomAD
CA412621369 rs1327707730	42	A>V		No	ClinGen TOPMed
CA412621375 rs1430580003	43	T>I		No	ClinGen gnomAD
rs769583415 CA10374718	52	G>E		No	ClinGen ExAC TOPMed gnomAD
rs1602822875 CA412621427	52	G>R		No	ClinGen Ensembl
TCGA novel	59	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA412621489 rs1276140430	60	G>D		No	ClinGen gnomAD
TCGA novel	60	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1342276847 CA412621491	61	G>R		No	ClinGen gnomAD
CA412621510 rs1221196809	63	P>L		No	ClinGen gnomAD
CA10374719 rs199614366	65	D>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA412621529 rs1191521291	66	A>D		No	ClinGen gnomAD
CA412621530 rs1191521291	66	A>G		No	ClinGen gnomAD
rs1168457286 CA412621527	66	A>P		No	ClinGen TOPMed
CA412621546 rs1449476551	69	E>K		No	ClinGen TOPMed gnomAD
rs1449476551 CA412621547	69	E>Q		No	ClinGen TOPMed gnomAD
CA412621563 rs1260857366	71	R>*		No	ClinGen gnomAD
CA412621570 rs1270142489	72	S>N		No	ClinGen gnomAD
rs1198343751 CA412621576	73	S>P		No	ClinGen TOPMed
CA10374720 rs772690346	74	D>Y		No	ClinGen 1000Genomes ExAC gnomAD
rs758559050 CA10374721	75	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA10374722 rs61739703 CA10374723	77	S>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1163117597 CA412621610	78	A>P		No	ClinGen TOPMed gnomAD
rs1163117597 CA412621611	78	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs760812430 CA412621618	79	S>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs760812430 CA10374725	79	S>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs767437527 CA328071125	84	L>F		No	ClinGen TOPMed
CA412621669 rs1459679252	86	S>N		No	ClinGen gnomAD
CA412621691 rs1294485367	89	D>Y		No	ClinGen TOPMed gnomAD
rs1380971696 CA412621715	92	H>Y		No	ClinGen gnomAD
rs757832106 CA10374726	95	M>I		No	ClinGen ExAC TOPMed gnomAD
CA412621759 rs1300457920	95	M>K		No	ClinGen gnomAD
CA412621775 rs1411593853	96	S>N		No	ClinGen TOPMed
rs1569200904 CA412621864	103	Y>N		No	ClinGen Ensembl
CA10374727 rs765751981	104	P>S		No	ClinGen ExAC gnomAD
CA328071127 rs978167632	106	V>A		No	ClinGen TOPMed
TCGA novel	106	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA412621917 rs1323137913	107	G>R		No	ClinGen gnomAD
TCGA novel	109	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs866243275 CA328071128 CA412622066	117	D>E		No	ClinGen TOPMed gnomAD
rs1259866073 CA412622064	117	D>G		No	ClinGen gnomAD
CA328071129 rs1036998620	118	E>*		No	ClinGen Ensembl
rs1431769234 CA412622098	120	I>L		No	ClinGen TOPMed
CA412622105 rs1602823746	120	I>M		No	ClinGen Ensembl
rs866054633 CA328071130	126	E>*		No	ClinGen Ensembl
rs1602824075 CA412622186	126	E>G		No	ClinGen Ensembl
CA412622180 rs866054633	126	E>Q		No	ClinGen Ensembl
CA412622198 rs1602824097	127	E>*		No	ClinGen Ensembl
CA412622232 rs1602824234	129	E>A		No	ClinGen Ensembl
rs1602824316 CA412622243	130	E>K		No	ClinGen Ensembl
CA412622264 rs758028919	131	E>G		No	ClinGen ExAC gnomAD
CA10374746 rs758028919	131	E>V		No	ClinGen ExAC gnomAD
rs1602824533 CA412622275	132	E>G		No	ClinGen Ensembl
rs1390536129 CA412622289	133	E>A		No	ClinGen gnomAD
rs1390536129 CA412622293	133	E>G		No	ClinGen gnomAD
rs1452129441 CA412622284	133	E>K		No	ClinGen gnomAD
CA412622286 rs1452129441	133	E>Q		No	ClinGen gnomAD
rs1602824633 CA412622309	134	E>G		No	ClinGen Ensembl
rs1602824633 CA412622310	134	E>V		No	ClinGen Ensembl
rs866365853 CA412622330	135	E>D		No	ClinGen TOPMed gnomAD
CA412622327 rs1376737603	135	E>V		No	ClinGen TOPMed
CA412622344 rs1380723288	136	E>G		No	ClinGen gnomAD
rs779792507 CA412622358	137	E>A		No	ClinGen ExAC gnomAD
CA412622354 rs1305889905	137	E>Q		No	ClinGen gnomAD
CA10374748 rs779792507	137	E>V		No	ClinGen ExAC gnomAD
CA10374749 rs751127231	138	E>V		No	ClinGen ExAC
CA412622396 rs1602824967	139	E>V		No	ClinGen Ensembl
CA412622404 rs1602825037	140	E>A		No	ClinGen Ensembl
CA412622399 rs1602825009	140	E>K		No	ClinGen Ensembl
rs866793818 CA328071137	141	E>G		No	ClinGen Ensembl
rs1602825321 CA412622456	143	E>G		No	ClinGen Ensembl
CA412622480 rs763951827	144	E>D		No	ClinGen 1000Genomes TOPMed
CA412622476 rs1569201321	144	E>G		No	ClinGen Ensembl
CA412622487 rs1361569258	145	E>K		No	ClinGen TOPMed
CA412622508 rs1257999618	146	E>G		No	ClinGen gnomAD
rs773661469	146	E>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1204666514 CA412622525	147	E>G		No	ClinGen gnomAD
rs1602825773 CA412622533	148	Q>K		No	ClinGen Ensembl
rs183895573 CA10374762	150	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs780614019 CA10374763	152	G>R		No	ClinGen ExAC TOPMed gnomAD
rs1360348922 CA412622602	153	P>L		No	ClinGen TOPMed gnomAD
CA10374764 rs748152249	154	Q>R		No	ClinGen ExAC gnomAD
TCGA novel	155	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10374765 rs769695775	156	S>G		No	ClinGen ExAC gnomAD
TCGA novel	156	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1602825932 CA412622643	157	G>C		No	ClinGen Ensembl
rs749138033 CA10374767	158	G>A		No	ClinGen ExAC gnomAD
rs777466794 CA10374766	158	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs775790927 CA10374769	159	N>K		No	ClinGen ExAC TOPMed gnomAD
CA10374768 rs770582913	159	N>T		No	ClinGen ExAC gnomAD
TCGA novel	162	Q>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA412622702 rs1602826074	162	Q>K		No	ClinGen Ensembl
rs186732901 CA10374770	162	Q>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10374771 rs768921538	163	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs1210887159 CA412622742	164	S>L		No	ClinGen gnomAD
CA328071143 rs998504444	167	E>*		No	ClinGen Ensembl
CA328071144 rs867674740	167	E>D		No	ClinGen gnomAD
rs1184625241 CA412622812	169	Q>R		No	ClinGen gnomAD
rs1602826287 CA412622820	170	A>S		No	ClinGen Ensembl
CA412622857 rs1189935131	173	E>K		No	ClinGen gnomAD
rs762462052 CA10374773	175	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1223007184 CA412622932	178	E>Q		No	ClinGen TOPMed
rs1169128381 CA412622947	179	T>A		No	ClinGen gnomAD
rs1432397701 CA412622958	180	S>P		No	ClinGen gnomAD
CA412622978 rs1490788619	181	A>V		No	ClinGen TOPMed
rs1196396916 CA412623001	184	R>G		No	ClinGen TOPMed gnomAD
CA412623005 rs1431192056	184	R>L		No	ClinGen gnomAD
rs1431192056 CA412623003	184	R>Q		No	ClinGen gnomAD
rs763402322 CA10374776	185	P>S		No	ClinGen ExAC TOPMed gnomAD
CA10374777 rs766595465	187	W>*		No	ClinGen ExAC gnomAD
rs1029609468 CA328071146	187	W>S		No	ClinGen Ensembl
rs1402898868 CA412623055	188	Q>P		No	ClinGen gnomAD
CA412623075 rs754622044	190	V>I		No	ClinGen ExAC TOPMed gnomAD
rs754622044 CA10374779	190	V>L		No	ClinGen ExAC TOPMed gnomAD
rs1217674384 CA412623107	191	T>I		No	ClinGen TOPMed
CA328071147 rs889600080	194	H>Q		No	ClinGen Ensembl
CA10374780 rs780740566	194	H>R		No	ClinGen ExAC TOPMed gnomAD
CA412623132 rs1340140765	194	H>Y		No	ClinGen gnomAD
rs1006746708 CA328071148	196	R>L		No	ClinGen gnomAD
CA412623166 rs1006746708	196	R>Q		No	ClinGen gnomAD
CA412623226 rs1602826811	201	R>C		No	ClinGen Ensembl
rs755579204 CA10374782	201	R>H		No	ClinGen ExAC TOPMed gnomAD
CA10374783 rs192576268	202	P>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1186460612 CA412623249	203	R>C		No	ClinGen gnomAD
CA412623247 rs1186460612	203	R>G		No	ClinGen gnomAD
rs1387718138 CA412623250	203	R>H		No	ClinGen TOPMed gnomAD
rs1450829150 CA412623253	204	F>I		No	ClinGen gnomAD
rs1168789529 CA412623270	205	V>L		No	ClinGen gnomAD
CA10374784 rs753453586	206	Y>C		No	ClinGen 1000Genomes ExAC gnomAD
rs1403290409 CA412623280	206	Y>H		No	ClinGen gnomAD
CA412623315 rs1350264353	208	A>V		No	ClinGen gnomAD
rs770761059 CA10374785	209	C>W		No	ClinGen ExAC TOPMed gnomAD
CA412623333 rs1268372070	210	G>R		No	ClinGen gnomAD
rs1363057347 CA412623348	211	A>T		No	ClinGen TOPMed gnomAD
CA10374786 rs778565096	212	R>K		No	ClinGen ExAC gnomAD
CA412623370 rs747290313	213	A>S		No	ClinGen ExAC TOPMed gnomAD
CA10374787 rs747290313	213	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1226877336 CA412623413	216	Q>*		No	ClinGen gnomAD
rs1292398178 CA412623427	217	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA412623435 rs776893287	217	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA10374789 rs776893287	217	R>L		No	ClinGen ExAC gnomAD
rs754671102 CA10374790	219	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs866230644 CA328071149	219	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
TCGA novel	223	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	223	R>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA412623507 rs779233435	223	R>H		No	ClinGen 1000Genomes ExAC gnomAD
CA10374792 rs779233435	223	R>L		No	ClinGen 1000Genomes ExAC gnomAD
CA10374793 rs779233435	223	R>P		No	ClinGen 1000Genomes ExAC gnomAD
rs1466678713 CA412623501	223	R>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA10374794 rs766835064	224	L>F		No	ClinGen ExAC gnomAD
CA10374795 rs774566918	226	D>G		No	ClinGen ExAC gnomAD
rs1414197775 CA412623575	229	G>C		No	ClinGen gnomAD
CA412623630 rs1481262501	233	T>S		No	ClinGen TOPMed
CA412623632 rs1390575808	234	V>I		No	ClinGen gnomAD
CA412623710 rs1249357069	239	R>H		No	ClinGen TOPMed
rs759237312 CA10374796	240	G>S		No	ClinGen ExAC gnomAD
CA10374798 rs752296463	242	R>Q		No	ClinGen ExAC gnomAD
rs184808826 CA10374797	242	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA412623800 rs1357438919	247	G>S		No	ClinGen gnomAD
TCGA novel	249	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1266672934 CA412623854	251	K>Q		No	ClinGen TOPMed gnomAD
CA10374802 rs757125796	254	V>A		No	ClinGen ExAC TOPMed gnomAD
CA412623915 rs1209970159	255	W>*		No	ClinGen gnomAD
rs1602827513 CA412623949	257	W>L		No	ClinGen Ensembl
CA10374803 rs778815167	259	R>P		No	ClinGen ExAC TOPMed
rs868568193 CA328071150	259	R>W		No	ClinGen gnomAD
CA328071151 rs61739721	261	R>K		No	ClinGen TOPMed gnomAD
rs758230587 CA412624029	263	V>I		No	ClinGen ExAC TOPMed gnomAD
CA10374805 rs758230587	263	V>L		No	ClinGen ExAC TOPMed gnomAD
CA10374809 rs773162776	268	S>T		No	ClinGen ExAC gnomAD
rs896879957 CA328071152	275	F>I		No	ClinGen TOPMed
CA412624241 rs1394389182	278	K>N		No	ClinGen gnomAD
CA10374810 rs749866387	282	N>T		No	ClinGen ExAC TOPMed gnomAD
rs1035080702 CA328071153	285	D>N		No	ClinGen TOPMed
rs1176623983 CA412624389	290	M>I		No	ClinGen TOPMed
rs1286838291 CA412624429	293	R>C		No	ClinGen gnomAD
rs774798584 CA10374813	296	Q>H		No	ClinGen ExAC gnomAD
rs1209372764 CA412624495	298	R>Q		No	ClinGen gnomAD
CA412624493 rs1331318623	298	R>W		No	ClinGen gnomAD
CA412624517 rs1229505367	300	A>P		No	ClinGen gnomAD
TCGA novel	301	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10374816 rs775127901	304	N>S		No	ClinGen ExAC TOPMed gnomAD
CA412624580 rs775127901	304	N>T		No	ClinGen ExAC TOPMed gnomAD
CA412624594 rs1419568161	305	A>E		No	ClinGen TOPMed
TCGA novel	311	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10374818 rs763714972	311	T>I		No	ClinGen ExAC gnomAD
CA328071154 rs771074246	313	C>G		No	ClinGen 1000Genomes gnomAD
CA412624700 rs771074246	313	C>R		No	ClinGen 1000Genomes gnomAD
CA10374820 rs757256245	313	C>Y		No	ClinGen ExAC gnomAD
rs765121695 CA10374821	314	V>L		No	ClinGen ExAC
CA328071155 rs1022167335	316	Q>K		No	ClinGen TOPMed gnomAD
TCGA novel	317	H>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1174390139 CA412624749	317	H>Y		No	ClinGen gnomAD
rs181875275 CA412624773	318	R>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	320	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10374824 rs367592851	321	A>T		No	ClinGen ExAC TOPMed gnomAD
CA10374825 rs748449236	323	K>E		No	ClinGen ExAC TOPMed gnomAD
rs977893155 CA328071156 CA412624850	324	L>F		No	ClinGen TOPMed gnomAD
rs1301060508 CA412624883	327	E>D		No	ClinGen gnomAD
CA10374826 rs759811140	328	P>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10374828 rs372484466	331	P>L		No	ClinGen ExAC gnomAD
CA10374829 rs372427910	332	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	333	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs966102479 CA328071157	334	F>L		No	ClinGen TOPMed gnomAD
TCGA novel	336	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	337	S>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs772488367 CA10374832	339	E>A		No	ClinGen ExAC gnomAD
rs111559275 CA328071160	343	V>A		No	ClinGen Ensembl
CA10374834 VAR_045620 rs5926895	345	T>A		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs78540534 CA328071161	345	T>S		No	ClinGen Ensembl
CA412625129 rs1454076832	346	I>T		No	ClinGen TOPMed
CA412625195 rs1430714333	351	D>V		No	ClinGen gnomAD
CA10374837 rs761253838	352	R>P		No	ClinGen ExAC TOPMed gnomAD
rs761253838 CA412625214	352	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA412625322 rs1388964876	361	R>K		No	ClinGen gnomAD
CA412625370 rs1363768259	364	D>G		No	ClinGen TOPMed gnomAD
CA412625368 rs1363768259	364	D>V		No	ClinGen TOPMed gnomAD
rs750395244 CA10374839	365	K>E		No	ClinGen ExAC TOPMed gnomAD
CA10374840 rs774285351	366	K>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA412625401 rs1342431806	366	K>T		No	ClinGen gnomAD
rs1489345812 CA412625438	369	L>P		No	ClinGen gnomAD
CA412625450 rs1353206463	370	Y>C		No	ClinGen TOPMed
rs1409517035 CA412625462	371	T>A		No	ClinGen gnomAD
CA10374843 rs756400313	373	T>S		No	ClinGen ExAC TOPMed gnomAD
rs777879257 CA10374844	374	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs757287423 CA10374846	377	A>T		No	ClinGen ExAC gnomAD
TCGA novel	378	N>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs369460010 CA328071163	378	N>S		No	ClinGen gnomAD
TCGA novel	381	Q>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA412625592 rs1459789404	381	Q>R		No	ClinGen gnomAD
TCGA novel	382	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs761676142 CA10374847	382	F>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1388510122 CA412625628	384	V>L		No	ClinGen gnomAD
rs746428763 CA10374848	389	Q>H		No	ClinGen ExAC gnomAD
TCGA novel	390	F>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs780433932 CA10374850	392	R>T		No	ClinGen ExAC gnomAD
rs1247482209 CA412625754	393	I>T		No	ClinGen TOPMed
rs1324193911 CA412625796	396	Q>R		No	ClinGen TOPMed
CA328071164 rs909436093	398	K>R		No	ClinGen TOPMed
CA412625842 rs1382438084	399	I>S		No	ClinGen TOPMed
rs1382438084 CA412625840	399	I>T		No	ClinGen TOPMed
CA412625850 rs1395026269	400	D>Y		No	ClinGen gnomAD
CA412625878 rs1310160254	402	K>E		No	ClinGen gnomAD
rs1386862155 CA412625885	402	K>I		No	ClinGen TOPMed
CA10374851 rs747363358	403	E>G		No	ClinGen ExAC gnomAD
CA412625891 rs1301122335	403	E>K		No	ClinGen TOPMed
rs776165375 CA10374853	405	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1326976739 CA412625938	406	G>S		No	ClinGen gnomAD
CA10374854 rs761465771	407	V>E		No	ClinGen ExAC gnomAD
rs1249902341 CA412625953	407	V>L		No	ClinGen gnomAD
rs368376110 CA10374855	409	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs781702266 CA328071165	409	K>R		No	ClinGen Ensembl
CA328071166 rs1056165880	414	H>R		No	ClinGen TOPMed gnomAD
CA10374857 rs763034072	415	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs1411767718 CA412626085	417	V>I		No	ClinGen gnomAD
rs1456061354 CA412626104	418	N>S		No	ClinGen gnomAD
rs1449017746 CA412626100	418	N>Y		No	ClinGen TOPMed
TCGA novel	421	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs868486185 CA412626166	422	P>L		No	ClinGen TOPMed
rs868486185 CA328071168	422	P>Q		No	ClinGen TOPMed
CA412626162 rs1222264025	422	P>S		No	ClinGen TOPMed
rs759260989 CA10374860	428	V>I		No	ClinGen ExAC TOPMed gnomAD
rs759260989 CA412626240	428	V>L		No	ClinGen ExAC TOPMed gnomAD
CA412626260 rs1336802957	429	V>A		No	ClinGen TOPMed
CA10374862 rs754070602	433	D>N		No	ClinGen ExAC gnomAD
TCGA novel	438	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs779012547 CA10374864	440	S>G		No	ClinGen ExAC TOPMed gnomAD
rs750469981 CA10374866	442	N>S		No	ClinGen ExAC gnomAD
rs750469981 CA10374865	442	N>T		No	ClinGen ExAC gnomAD
rs780562926 CA10374867	443	D>N		No	ClinGen ExAC TOPMed gnomAD
CA10374869 rs747493517	444	D>E		No	ClinGen ExAC TOPMed gnomAD
rs966189526 CA328071169	445	D>N		No	ClinGen TOPMed
rs976570296 CA328071170	450	N>S		No	ClinGen TOPMed
TCGA novel	451	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA328071171 rs1029038901	452	S>P		No	ClinGen TOPMed
CA10374871 rs185264593	453	H>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs185264593 CA10374870	453	H>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10374872 rs769551706	454	S>T		No	ClinGen ExAC gnomAD
rs1427407179 CA412626540	459	Y>H		No	ClinGen TOPMed
CA10374875 rs770506122	462	R>K		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	470	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1203029171 CA412626635	472	V>I		No	ClinGen TOPMed
rs759509987 CA10374877	473	K>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs77842814 CA328071173	476	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA10374879 rs775333139	478	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA412626681 rs1466181631	479	G>S		No	ClinGen TOPMed gnomAD
CA10374880 rs762061938	480	P>S		No	ClinGen ExAC gnomAD
CA10374881 rs765473427	482	S>N		No	ClinGen ExAC gnomAD
rs1411393990 CA412626728	486	V>L		No	ClinGen gnomAD
CA412626738 rs1288803692	487	S>T		No	ClinGen gnomAD
rs375048390 CA10374882	488	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	489	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA328071174 rs770168129	491	C>R		No	ClinGen Ensembl
CA412626772 rs1314034170	492	G>E		No	ClinGen gnomAD
CA10374884 rs754617893	492	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA412626779 rs1211802180	493	H>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	496	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA412626822 rs1276460337	498	E>D		No	ClinGen TOPMed
rs1439910357 CA412626859	504	I>L		No	ClinGen TOPMed
rs1369467763 CA412626893	508	L>R		No	ClinGen gnomAD
rs781462348 CA10374887	511	S>N		No	ClinGen ExAC TOPMed gnomAD
rs748517593 CA10374888	514	G>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	516	I>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10374889 rs756510078	517	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1175882499 CA412626959	518	C>S		No	ClinGen TOPMed
rs1454358876 CA412626967	519	L>P		No	ClinGen gnomAD
CA10374891 rs748880674	522	H>Y		No	ClinGen ExAC gnomAD
CA412626994 rs1308405971	523	P>R		No	ClinGen TOPMed gnomAD
rs1431312373 CA412626991	523	P>S		No	ClinGen gnomAD
TCGA novel	527	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1235069743 CA412627034	530	C>S		No	ClinGen gnomAD
CA328071175 rs764872814	531	S>N		No	ClinGen 1000Genomes
CA10374894 rs752945235	533	L>P		No	ClinGen 1000Genomes ExAC gnomAD
CA412627069 rs1458665191	535	H>Y		No	ClinGen TOPMed
TCGA novel	536	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10374896 rs775249498	538	K>N		No	ClinGen ExAC TOPMed gnomAD
CA10374895 rs772014311	538	K>R		No	ClinGen ExAC TOPMed
CA412627112 rs1451417966	541	T>A		No	ClinGen gnomAD
TCGA novel	543	T>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA412627134 rs1429515468	544	A>V		No	ClinGen gnomAD
rs1219956197 CA412627144	546	A>P		No	ClinGen gnomAD
rs1280438576 CA412627158	548	T>I		No	ClinGen TOPMed
CA10374898 rs763821681	548	T>S		No	ClinGen ExAC gnomAD
rs181130142 CA10374899	554	K>E		No	ClinGen 1000Genomes ExAC gnomAD
CA10374900 rs763158183	557	I>M		No	ClinGen ExAC TOPMed gnomAD
rs1167053977 CA412627218	557	I>T		No	ClinGen gnomAD
rs1168146860 CA412627252	562	W>R		No	ClinGen gnomAD
CA412627265 rs1448905243	563	E>G		No	ClinGen TOPMed
rs1403423572 CA412627273	564	R>L		No	ClinGen TOPMed gnomAD
rs1403423572 CA412627271	564	R>Q		No	ClinGen TOPMed gnomAD
TCGA novel	572	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1453623269 CA412627366	577	Q>E		No	ClinGen TOPMed
CA412627398 rs1408623996	581	W>*		No	ClinGen TOPMed
rs751640381 CA10374902	582	F>V		No	ClinGen ExAC
rs1319899618 CA412627425	585	R>H		No	ClinGen gnomAD
CA10374904 rs768103245	587	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1271024801 CA412627442	588	T>A		No	ClinGen gnomAD
rs780658256 CA10374905	588	T>M		No	ClinGen ExAC TOPMed gnomAD
CA10374908 rs749003242	591	G>D		No	ClinGen ExAC gnomAD
CA412627461 rs1569202769	591	G>S		No	ClinGen Ensembl
CA10374909 rs372187026	592	R>H		No	ClinGen ExAC TOPMed gnomAD
rs372187026 CA412627469	592	R>P		No	ClinGen ExAC TOPMed gnomAD
CA10374910 rs778326298	598	S>N		No	ClinGen ExAC
rs1182492891 CA412627566	605	D>E		No	ClinGen TOPMed
rs771433281 CA10374912	606	E>G		No	ClinGen ExAC TOPMed gnomAD
CA412627586 rs1193399951	608	S>L		No	ClinGen TOPMed gnomAD
CA412627587 rs1193399951	608	S>W		No	ClinGen TOPMed gnomAD
CA412627592 rs1236500180	609	D>G		No	ClinGen gnomAD
rs903803033 CA328071176	609	D>N		No	ClinGen TOPMed gnomAD
rs1471631930 CA412627602	610	E>D		No	ClinGen gnomAD
CA10374913 rs780052340	612	S>P		No	ClinGen ExAC gnomAD
TCGA novel	613	S>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA412627628 rs1284770011	614	T>I		No	ClinGen TOPMed
rs768507589 CA10374915	616	E>G		No	ClinGen ExAC gnomAD
rs868500463 CA328071177	620	E>K		No	ClinGen Ensembl
rs776397820 CA10374916	622	V>I		No	ClinGen ExAC gnomAD
rs1314429748 CA412627686	623	Q>R		No	ClinGen TOPMed
TCGA novel	624	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA412627698 rs1319121489	625	R>*		No	ClinGen TOPMed gnomAD
CA412627699 rs1319121489	625	R>G		No	ClinGen TOPMed gnomAD
CA412627700 rs377420810	625	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA328071179 rs377420810	625	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10374917 rs377420810	625	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA10374918 rs771157842	626	V>A		No	ClinGen ExAC TOPMed gnomAD
rs1346144821 CA412627711	627	Q>R		No	ClinGen TOPMed
CA328071180 rs901676216	629	M>L		No	ClinGen TOPMed gnomAD
TCGA novel	631	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA

No associated diseases with P0C7V8

No regional properties for P0C7V8

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for P0C7V8

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
Cul4-RING E3 ubiquitin ligase complex	A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

No GO annotations of biological process

Name	Definition
No GO annotations for biological process

4 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A6NGE4	DCAF8L1	DDB1- and CUL4-associated factor 8-like protein 1	Homo sapiens (Human)	PR
Q58WW2	DCAF6	DDB1- and CUL4-associated factor 6	Homo sapiens (Human)	PR
Q5TAQ9	DCAF8	DDB1- and CUL4-associated factor 8	Homo sapiens (Human)	PR
Q9DC22	Dcaf6	DDB1- and CUL4-associated factor 6	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MSHQEGSTDG	LPDLGTESLF	SSPEEQSGAV	AATEASSDID	IATSELSVTV	TGDGSDSRDG
70	80	90	100	110	120
GFPNDASTEN	RSSDQESASE	DIELESLEDF	EHFLMSGESL	FHYPLVGEEE	TEREEEDEEI
130	140	150	160	170	180
QEEGGEEEEE	EEEEEEEEEE	EEEEEEEQPR	AGPQGSGGNH	EQYSLEEDQA	LEEWVSSETS
190	200	210	220	230	240
ALPRPRWQVV	TALHQRQLGS	RPRFVYEACG	ARAFVQRFRL	QYRLADHVGC	VNTVHFNQRG
250	260	270	280	290	300
TRLASSGDDL	KVIVWDWVRQ	RPVLNFESGH	TNNVFQAKFL	PNCGDSTLAM	CARDGQVRVA
310	320	330	340	350	360
ELINASYFNN	TKCVAQHRGP	AHKLALEPDS	PYKFLTSGED	AVVFTIDLRQ	DRPASKVVVT
370	380	390	400	410	420
RENDKKVGLY	TITVNPANTY	QFAVGGQDQF	VRIYDQRKID	KKENNGVLKK	FTPHHLVNCD
430	440	450	460	470	480
FPTNITCVVY	SHDGTELLAS	YNDDDIYLFN	SSHSDGAQYS	KRFKGHRNNT	TVKGVNFYGP
490	500	510	520	530	540
RSEFVVSGSD	CGHIFFWEKS	SCQIIQFLKG	SREGTINCLE	PHPYLPVLAC	SGLDHDVKIW
550	560	570	580	590	600
TPTAKAATEL	TGLKKVIKKN	KWERDEDSLH	HGSLFDQYML	WFLLRHVTQR	GRHQDWRSGE
610	620	630
AEFPDEESDE	SSSTSETSEE	EVQDRVQCMP	S