A6NGE4
PR
Gene name |
DCAF8L1 (WDR42B) |
Protein name |
DDB1- and CUL4-associated factor 8-like protein 1 |
Names |
WD repeat-containing protein 42B |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:139425 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A6NGE4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A6NGE4-F1 | Predicted | AlphaFoldDB |
362 variants for A6NGE4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| TCGA novel | 1 | M>? | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1401645275 CA412631774 |
2 | S>Y | No |
ClinGen TOPMed |
|
|
CA10375328 rs754784040 |
3 | H>Y | No |
ClinGen ExAC gnomAD |
|
|
rs1322023738 CA412631744 |
6 | G>A | No |
ClinGen gnomAD |
|
|
CA412631741 rs1158479293 |
7 | S>G | No |
ClinGen TOPMed |
|
|
CA412631731 rs1569233158 |
8 | T>K | No |
ClinGen Ensembl |
|
|
CA10375326 rs145556673 |
9 | G>R | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA10375325 rs145556673 |
9 | G>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA328094680 rs200028096 |
10 | G>S | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA412631693 rs1339019610 |
14 | L>F | No |
ClinGen gnomAD |
|
|
rs764776423 CA10375323 |
14 | L>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10375322 rs761423990 |
15 | V>G | No |
ClinGen ExAC gnomAD |
|
|
rs866774220 CA328094679 |
16 | T>I | No |
ClinGen Ensembl |
|
|
rs776215046 CA328094678 |
20 | F>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs776215046 CA10375321 |
20 | F>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10375320 rs769053531 |
25 | E>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA10375319 rs760962915 |
26 | Q>K | No |
ClinGen ExAC gnomAD |
|
|
rs199777052 CA10375318 |
27 | S>T | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs772740831 CA10375317 |
29 | V>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM1740815 rs754610980 CA10375315 |
31 | A>V | haematopoietic_and_lymphoid_tissue [Cosmic] | No |
ClinGen cosmic curated TOPMed |
|
rs771199172 CA10375312 |
32 | V>A | No |
ClinGen ExAC gnomAD |
|
|
rs749505405 CA10375311 |
33 | T>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10375308 rs149699902 |
33 | T>K | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA10375309 rs149699902 |
33 | T>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA10375310 rs149699902 |
33 | T>R | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs201140749 CA10375307 |
34 | A>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA412631560 rs1467714727 |
36 | S>F | No |
ClinGen gnomAD |
|
|
rs142088230 CA10375304 |
39 | I>T | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1262144650 CA412631544 |
39 | I>V | No |
ClinGen gnomAD |
|
|
rs200447635 CA10375303 |
40 | E>D | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA10375302 rs201120549 |
41 | M>I | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1370218521 CA412631521 COSM4005068 |
42 | A>E | urinary_tract [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
rs763661538 CA10375301 |
42 | A>T | No |
ClinGen ExAC gnomAD |
|
|
rs774529531 CA10375299 |
43 | A>T | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs202120447 CA10375298 |
44 | T>S | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA412631508 rs1333520790 |
45 | E>K | No |
ClinGen gnomAD |
|
| TCGA novel | 47 | S>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs903620852 CA328094677 |
47 | S>W | No |
ClinGen TOPMed |
|
|
CA412631480 rs1433664579 |
49 | G>A | No |
ClinGen gnomAD |
|
|
CA328094676 rs199936225 |
49 | G>R | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes NCI-TCGA TOPMed |
|
rs749330123 CA10375294 |
51 | G>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA412631468 rs749330123 |
51 | G>D | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA412631471 rs1427037700 |
51 | G>S | No |
ClinGen TOPMed gnomAD |
|
|
CA10375293 rs770418324 |
52 | G>D | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA10375292 rs769929879 |
53 | D>E | No |
ClinGen ExAC |
|
|
CA412631457 rs1238404046 |
53 | D>G | No |
ClinGen gnomAD |
|
|
CA10375291 rs748450249 |
55 | R>G | No |
ClinGen ExAC gnomAD |
|
|
CA10375290 rs61735183 |
55 | R>K | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 58 | G>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10375287 COSM3844421 rs778836758 |
61 | N>K | Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
rs1314393087 CA412631390 |
63 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
rs756691632 CA10375286 |
65 | T>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10375285 rs753323292 |
67 | N>S | No |
ClinGen ExAC gnomAD |
|
|
rs763757804 CA10375284 |
73 | E>G | No |
ClinGen ExAC gnomAD |
|
|
rs755704552 CA10375283 |
74 | S>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA412631281 rs1196316727 |
79 | V>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs1196316727 CA412631280 |
79 | V>L | No |
ClinGen TOPMed |
|
|
COSM184529 CA10375281 rs767977769 |
80 | E>K | Variant assessed as Somatic; 0.0 impact. large_intestine endometrium skin [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs150703703 CA10375280 |
81 | L>F | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 83 | S>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA412631248 rs1387004599 |
83 | S>R | No |
ClinGen gnomAD |
|
|
rs774930853 CA10375279 |
84 | M>I | No |
ClinGen ExAC gnomAD |
|
|
CA10375278 rs374009296 |
89 | F>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA412631202 rs763039543 |
90 | G>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10375277 rs763039543 |
90 | G>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1420269051 CA412631187 |
92 | P>L | No |
ClinGen TOPMed |
|
|
CA412631175 rs1465211267 |
94 | V>A | No |
ClinGen TOPMed |
|
| TCGA novel | 97 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10375274 rs748314306 |
98 | T>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs143412143 CA328094673 COSM109974 |
106 | E>K | skin [Cosmic] | No |
ClinGen cosmic curated Ensembl |
|
CA10375267 rs148567837 |
107 | M>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs778785427 CA10375268 |
107 | M>K | No |
ClinGen ExAC |
|
|
rs778785427 CA10375269 |
107 | M>R | No |
ClinGen ExAC |
|
|
CA412631068 rs1238280530 |
109 | E>G | No |
ClinGen gnomAD |
|
|
CA10375266 rs749300787 |
109 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA412631057 rs1313539603 |
110 | E>D | No |
ClinGen gnomAD |
|
|
CA328094672 rs867105386 |
111 | G>E | No |
ClinGen Ensembl |
|
|
rs1477465033 CA412631055 |
111 | G>R | No |
ClinGen TOPMed gnomAD |
|
|
CA10375262 rs755704268 |
117 | P>R | No |
ClinGen ExAC gnomAD |
|
|
rs1433981521 CA412631008 |
117 | P>S | No |
ClinGen gnomAD |
|
|
rs755353352 CA10375259 |
118 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs1602935033 CA412630996 |
119 | M>I | No |
ClinGen Ensembl |
|
|
CA10375257 rs766898288 |
119 | M>T | No |
ClinGen ExAC gnomAD |
|
|
rs1447453675 CA412630992 |
120 | C>R | No |
ClinGen gnomAD |
|
|
CA10375256 rs763337544 |
122 | R>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA412630970 rs1204217365 |
123 | C>F | No |
ClinGen gnomAD |
|
|
rs201777389 CA10375253 |
124 | G>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs776769197 CA10375252 |
125 | G>D | No |
ClinGen ExAC gnomAD |
|
|
rs200483414 CA10375251 |
126 | T>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10375250 rs202016467 |
126 | T>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10375249 rs774114403 |
127 | N>S | No |
ClinGen ExAC gnomAD |
|
|
CA10375248 rs765227684 |
128 | H>R | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA412630944 rs1280803117 |
128 | H>Y | No |
ClinGen gnomAD |
|
|
CA10375245 rs146077046 |
129 | D>E | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs374507128 CA10375246 |
129 | D>H | No |
ClinGen ESP ExAC TOPMed |
|
|
CA10375243 rs371111312 |
130 | Q>L | No |
ClinGen ESP ExAC gnomAD |
|
|
CA10375244 rs371111312 |
130 | Q>P | No |
ClinGen ESP ExAC gnomAD |
|
|
rs751297172 CA10375241 |
131 | C>Y | No |
ClinGen ExAC gnomAD |
|
|
rs780277664 CA10375240 |
132 | L>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs750838544 CA10375239 |
134 | D>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1163512525 CA412630899 |
135 | E>K | No |
ClinGen gnomAD |
|
|
CA10375237 rs142810555 |
136 | D>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1426405344 CA412630885 |
137 | Q>E | No |
ClinGen TOPMed gnomAD |
|
|
rs761760730 CA10375236 |
137 | Q>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10375233 rs375220315 |
140 | E>K | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs759874078 CA328094670 |
141 | E>* | No |
ClinGen TOPMed |
|
|
CA10375232 rs61735182 |
143 | I>V | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1355549463 CA412630831 |
144 | S>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs770570637 CA10375231 |
145 | S>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10375230 rs762808589 |
146 | E>G | No |
ClinGen ExAC TOPMed |
|
|
rs140377946 CA10375228 |
147 | T>I | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs746654902 CA10375224 |
151 | P>T | No |
ClinGen ExAC gnomAD |
|
|
rs779760110 CA412630791 COSM1249754 |
152 | R>* | oesophagus [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA10375223 rs779760110 |
152 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs137944442 CA10375222 |
152 | R>Q | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs750819645 CA10375221 |
153 | S>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10375220 COSM1119708 rs201727969 |
154 | R>C | Variant assessed as Somatic; 6.324e-05 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
CA10375219 rs757727199 |
154 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs754388247 CA10375218 |
155 | W>R | No |
ClinGen ExAC gnomAD |
|
|
CA10375217 rs764141269 |
156 | Q>E | No |
ClinGen ExAC gnomAD |
|
|
CA10375215 rs142121147 |
158 | L>V | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs200841569 CA10375214 |
159 | T>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA412630751 rs1602934820 |
159 | T>S | No |
ClinGen Ensembl |
|
|
rs777162966 COSM1636493 CA10375213 |
162 | R>C | Variant assessed as Somatic; 0.0 impact. liver [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
CA10375212 rs147601047 |
162 | R>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs145123475 CA10375210 |
164 | R>Q | No |
ClinGen ESP ExAC gnomAD |
|
|
CA10375211 rs771155325 |
164 | R>W | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs776776307 CA10375209 |
169 | S>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10375208 rs768214773 |
170 | A>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs370259094 CA10375207 |
171 | R>C | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1368406319 CA412630682 |
171 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs1239331730 CA412630678 |
172 | F>I | No |
ClinGen TOPMed |
|
|
rs377113145 CA10375204 |
174 | Y>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA412630664 rs1310358832 |
174 | Y>H | No |
ClinGen TOPMed |
|
|
CA328094669 rs923925597 |
180 | R>T | No |
ClinGen TOPMed gnomAD |
|
|
rs757672175 CA10375202 |
181 | T>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA412630603 rs1174734878 |
183 | V>L | No |
ClinGen gnomAD |
|
| TCGA novel | 184 | Q>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10375200 rs778270304 COSM1119707 |
185 | R>H | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs200108741 CA10375199 |
187 | R>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs752855706 CA10375198 |
187 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs767536618 CA10375197 |
189 | Q>H | No |
ClinGen ExAC gnomAD |
|
|
CA412630565 rs1279227995 |
189 | Q>P | No |
ClinGen gnomAD |
|
| TCGA novel | 191 | L>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10375196 rs777227762 |
196 | A>S | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA10375194 rs765119036 |
197 | G>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA10375193 rs761704041 |
198 | S>C | No |
ClinGen ExAC gnomAD |
|
|
CA412630481 rs1277332532 |
202 | I>V | No |
ClinGen gnomAD |
|
|
rs148833488 CA10375191 |
207 | R>C | No |
ClinGen ESP ExAC gnomAD |
|
|
rs148833488 CA10375192 |
207 | R>G | No |
ClinGen ESP ExAC gnomAD |
|
|
CA10375190 rs760221266 |
207 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs760221266 CA412630441 |
207 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs148833488 CA412630443 |
207 | R>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA gnomAD |
|
rs775032071 CA10375189 |
208 | G>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10375188 rs61735181 |
210 | R>* | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
COSM1119706 rs1406061651 CA412630428 |
210 | R>Q | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
|
rs1473154987 CA412630412 |
213 | S>G | No |
ClinGen TOPMed gnomAD |
|
|
CA10375186 rs773938102 |
213 | S>N | No |
ClinGen ExAC gnomAD |
|
|
rs771232314 CA10375185 |
214 | S>I | No |
ClinGen ExAC gnomAD |
|
|
CA10375182 rs189119937 |
215 | G>A | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA10375183 rs149659642 |
215 | G>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1318413945 CA412630389 |
216 | D>E | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 216 | D>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 218 | L>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs781320020 CA10375180 |
219 | R>K | No |
ClinGen ExAC gnomAD |
|
|
CA412630368 rs1306267671 |
219 | R>S | No |
ClinGen TOPMed |
|
|
CA412630364 rs1356472383 |
220 | V>M | No |
ClinGen gnomAD |
|
|
rs1294539110 CA412630354 |
221 | I>M | No |
ClinGen gnomAD |
|
|
rs1313361123 CA412630340 |
223 | W>C | No |
ClinGen TOPMed |
|
|
rs1233179975 CA412630334 |
224 | D>G | No |
ClinGen TOPMed |
|
|
rs139420081 CA10375178 |
227 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10375179 rs755079445 |
227 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA412630311 rs1433314495 |
228 | Q>K | No |
ClinGen gnomAD |
|
|
CA328094668 rs150894544 |
229 | K>R | No |
ClinGen ESP TOPMed |
|
|
rs1602934535 CA412630288 |
231 | V>A | No |
ClinGen Ensembl |
|
|
rs757067588 CA328094667 |
231 | V>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs757067588 CA10375176 |
231 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA412630285 rs1602934528 |
232 | L>V | No |
ClinGen Ensembl |
|
| TCGA novel | 235 | E>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 237 | G>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10375173 rs760635762 |
238 | H>Q | No |
ClinGen ExAC gnomAD |
|
|
rs1195330470 COSM227959 CA412630236 |
239 | D>N | NS Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated NCI-TCGA TOPMed |
|
rs1417061719 CA412630213 |
242 | V>I | No |
ClinGen gnomAD |
|
|
CA10375172 rs752630593 |
243 | I>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA412630170 rs1214658265 |
248 | F>L | No |
ClinGen gnomAD |
|
| TCGA novel | 248 | F>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1173901581 CA412630161 |
249 | P>S | No |
ClinGen TOPMed |
|
|
CA412630123 rs1274514972 |
254 | S>F | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA10375168 rs143799037 |
257 | A>V | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA10375167 rs762636057 |
259 | C>R | No |
ClinGen ExAC gnomAD |
|
|
CA10375165 rs770204101 |
272 | N>K | No |
ClinGen ExAC gnomAD |
|
|
rs748685130 CA10375164 |
275 | Y>H | No |
ClinGen ExAC gnomAD |
|
|
CA10375163 rs781555980 |
276 | C>F | No |
ClinGen ExAC gnomAD |
|
|
rs780381603 CA10375160 |
277 | E>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs140126853 CA10375161 |
277 | E>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs758661238 CA10375159 |
281 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs146103278 CA10375158 COSM3939930 |
281 | R>H | Variant assessed as Somatic; 0.0 impact. oesophagus [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs146103278 CA412629946 |
281 | R>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10375157 rs142837894 |
284 | K>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1185651686 CA412629907 |
287 | G>E | No |
ClinGen gnomAD |
|
|
CA412629904 rs1478192197 |
288 | P>S | No |
ClinGen gnomAD |
|
|
rs369821812 CA10375155 |
291 | E>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA gnomAD |
|
rs1207272594 CA412629819 |
300 | Y>* | No |
ClinGen gnomAD |
|
| TCGA novel | 302 | F>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 303 | L>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10375152 rs751042138 |
304 | T>I | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 306 | G>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 309 | A>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1042366741 CA328094665 |
309 | A>T | No |
ClinGen TOPMed gnomAD |
|
|
CA10375150 rs762582589 COSM1558027 |
310 | V>F | lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA10375151 rs762582589 |
310 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs762582589 CA412629758 |
310 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 313 | T>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs772916584 CA10375149 |
314 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA10375144 rs747589488 |
320 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
CA10375146 rs755798442 |
320 | R>W | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs775686012 CA10375143 |
321 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA10375142 rs772333500 |
322 | A>P | No |
ClinGen ExAC gnomAD |
|
|
CA10375141 rs746079607 |
324 | K>R | No |
ClinGen ExAC |
|
|
CA412629632 rs1238267828 |
330 | E>K | No |
ClinGen gnomAD |
|
|
CA10375138 rs747928959 |
332 | D>E | No |
ClinGen ExAC |
|
|
CA10375139 rs755893299 |
332 | D>N | No |
ClinGen ExAC TOPMed |
|
|
rs755893299 CA412629615 |
332 | D>Y | No |
ClinGen ExAC TOPMed |
|
| TCGA novel | 333 | K>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 335 | V>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs754851379 COSM1467368 CA10375136 |
336 | G>R | Variant assessed as Somatic; 0.0 impact. large_intestine skin [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
CA10375134 rs763210557 |
341 | S>T | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs192362248 CA10375133 |
342 | M>V | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1354597657 CA412629523 |
346 | N>D | No |
ClinGen TOPMed gnomAD |
|
|
rs762197074 CA10375130 |
349 | Q>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA |
|
CA412629483 rs1602934226 |
351 | A>E | No |
ClinGen Ensembl |
|
|
rs1309332127 CA412629456 |
355 | H>Q | No |
ClinGen gnomAD |
|
|
rs1602934215 CA412629430 |
359 | V>I | No |
ClinGen Ensembl |
|
|
CA412629368 rs1371158112 |
367 | I>T | No |
ClinGen TOPMed gnomAD |
|
|
TCGA novel CA10375128 rs764567419 |
369 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ExAC TOPMed gnomAD NCI-TCGA |
|
CA328094661 rs760146014 |
370 | K>E | No |
ClinGen 1000Genomes |
|
| TCGA novel | 372 | N>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs776203404 CA10375126 |
374 | G>A | No |
ClinGen ExAC gnomAD |
|
|
CA412629313 rs1433723422 |
375 | V>I | No |
ClinGen gnomAD |
|
|
CA412629306 rs1160717407 |
376 | L>F | No |
ClinGen gnomAD |
|
|
CA412629307 rs1160717407 |
376 | L>V | No |
ClinGen gnomAD |
|
|
rs771032379 CA10375122 |
382 | H>R | No |
ClinGen ExAC TOPMed |
|
|
rs1215819339 CA412629257 |
383 | H>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs189411535 CA10375121 |
386 | Y>N | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1255851387 CA412629202 |
391 | T>A | No |
ClinGen gnomAD |
|
|
rs1210613816 CA412629198 |
391 | T>I | No |
ClinGen gnomAD |
|
|
CA412629165 COSM1467366 rs1228225117 |
396 | V>A | large_intestine [Cosmic] | No |
ClinGen cosmic curated TOPMed gnomAD |
|
rs754870602 CA10375119 COSM74329 |
396 | V>I | ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA10375118 rs746882738 |
397 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10375117 rs779981615 |
398 | Y>S | No |
ClinGen ExAC gnomAD |
|
|
CA412629146 rs1347319938 |
399 | S>N | No |
ClinGen TOPMed |
|
|
CA412629135 rs1310904525 |
401 | D>H | No |
ClinGen TOPMed gnomAD |
|
|
CA412629134 rs1310904525 |
401 | D>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs756835736 CA10375113 |
405 | L>H | No |
ClinGen ExAC gnomAD |
|
|
CA10375112 rs753582398 |
408 | S>N | No |
ClinGen ExAC gnomAD |
|
|
CA10375111 rs764359472 |
409 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
rs776078422 CA10375109 |
412 | E>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10375108 rs768173990 |
413 | D>G | No |
ClinGen ExAC gnomAD |
|
|
rs371742961 CA10375107 |
418 | N>S | No |
ClinGen ESP ExAC gnomAD |
|
|
rs200947185 CA328094658 |
419 | S>A | No |
ClinGen TOPMed gnomAD |
|
|
rs200947185 CA328094657 |
419 | S>P | No |
ClinGen TOPMed gnomAD |
|
|
rs1447910474 CA412628998 |
421 | L>H | No |
ClinGen gnomAD |
|
|
rs1447910474 CA412628997 |
421 | L>P | No |
ClinGen gnomAD |
|
|
rs1264254164 CA412628990 |
422 | S>I | No |
ClinGen gnomAD |
|
|
rs1203638319 CA412628983 |
423 | D>G | No |
ClinGen TOPMed gnomAD |
|
|
CA10375105 rs771104433 |
424 | G>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10375102 rs768382125 |
431 | Y>F | No |
ClinGen ExAC gnomAD |
|
|
CA10375101 rs746829557 |
435 | R>I | No |
ClinGen ExAC gnomAD |
|
|
CA412628845 rs1297381003 |
442 | C>* | No |
ClinGen gnomAD |
|
|
CA10375100 rs779926344 |
443 | V>I | No |
ClinGen ExAC gnomAD |
|
|
CA10375099 rs773615533 |
445 | F>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
CA10375098 rs745864503 |
446 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
CA10375093 rs138650117 |
449 | R>Q | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs777491492 CA10375094 |
449 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA412628778 rs1191403049 |
452 | F>L | No |
ClinGen gnomAD |
|
|
CA10375090 rs760109139 COSM1119698 |
454 | V>M | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
rs766304714 CA10375088 |
455 | S>G | No |
ClinGen ExAC gnomAD |
|
|
CA412628759 rs1209179925 |
456 | G>S | No |
ClinGen gnomAD |
|
|
CA10375086 rs773259232 |
460 | G>R | No |
ClinGen ExAC gnomAD |
|
|
rs747769144 CA10375085 |
462 | V>I | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs762062087 CA10375084 |
465 | W>L | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 472 | I>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA412628636 rs1602933871 |
473 | I>F | No |
ClinGen Ensembl |
|
|
CA10375083 COSM1119696 rs775242035 |
474 | Q>* | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
rs1569232566 TCGA novel CA412628601 |
477 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
NCI-TCGA ClinGen Ensembl |
|
rs1358660017 CA412628586 |
479 | D>E | No |
ClinGen TOPMed |
|
|
CA412628593 rs1334854011 |
479 | D>N | No |
ClinGen TOPMed |
|
|
rs1471660061 CA412628585 |
480 | R>G | No |
ClinGen TOPMed gnomAD |
|
|
CA412628576 rs1300140119 |
481 | G>* | No |
ClinGen TOPMed |
|
|
rs1368177318 CA412628568 |
482 | D>G | No |
ClinGen gnomAD |
|
|
CA412628561 rs1411023358 |
483 | I>T | No |
ClinGen TOPMed gnomAD |
|
|
rs771911063 CA10375082 |
483 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs745785986 CA10375081 |
487 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 495 | V>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 497 | A>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA328094654 rs745341683 |
499 | S>T | No |
ClinGen Ensembl |
|
|
CA412628395 rs1452744688 |
508 | W>R | No |
ClinGen gnomAD |
|
| TCGA novel | 512 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs770284640 CA10375079 |
513 | K>E | No |
ClinGen ExAC gnomAD |
|
|
CA10375078 rs777469548 |
514 | T>A | No |
ClinGen ExAC gnomAD |
|
|
CA10375077 rs777469548 |
514 | T>P | No |
ClinGen ExAC gnomAD |
|
|
CA412628348 rs1252554186 |
515 | A>V | No |
ClinGen gnomAD |
|
|
CA328094653 rs879063476 |
517 | E>K | No |
ClinGen Ensembl |
|
|
CA10375076 rs755809602 |
519 | T>I | No |
ClinGen ExAC gnomAD |
|
|
rs1280717513 CA412628296 |
523 | D>E | No |
ClinGen gnomAD |
|
|
CA10375075 rs752458196 |
524 | V>A | No |
ClinGen ExAC TOPMed |
|
|
CA10375074 rs781689773 |
525 | I>M | No |
ClinGen ExAC gnomAD |
|
|
rs55924991 CA328094651 |
529 | K>R | No |
ClinGen Ensembl |
|
|
rs1569232519 CA412628227 |
533 | D>G | No |
ClinGen Ensembl |
|
|
CA10375071 rs766931484 |
534 | E>G | No |
ClinGen ExAC gnomAD |
|
|
CA10375070 rs138100395 |
540 | T>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA412628167 rs1178470373 |
541 | D>V | No |
ClinGen TOPMed |
|
| TCGA novel | 542 | S>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs368290304 CA10375069 |
542 | S>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA10375068 rs765350190 |
544 | D>G | No |
ClinGen ExAC gnomAD |
|
|
rs762007041 CA10375067 |
545 | N>D | No |
ClinGen ExAC gnomAD |
|
|
rs199848612 CA10375065 |
546 | R>C | Variant assessed as Somatic; 6.252e-05 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
CA10375064 rs759385649 |
546 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA10375066 rs199848612 |
546 | R>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA10375063 rs774103564 |
549 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA328094650 rs12388557 VAR_038060 |
549 | R>W | No |
ClinGen UniProt 1000Genomes TOPMed dbSNP |
|
|
rs770928929 COSM756409 CA412628099 |
552 | V>L | lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA10375062 rs770928929 |
552 | V>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
COSM1119693 rs749236143 CA10375061 |
553 | R>C | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs772839233 CA10375060 |
553 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs1274233751 CA412628065 |
557 | Q>H | No |
ClinGen TOPMed |
|
|
rs1482655317 CA412628067 |
557 | Q>R | No |
ClinGen TOPMed gnomAD |
|
|
CA10375059 rs779921759 |
558 | R>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs747739698 CA10375058 |
559 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10375057 rs781006830 |
559 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs372380763 CA10375056 |
561 | Q>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10375055 rs747432511 |
562 | P>T | No |
ClinGen ExAC |
|
|
CA412628032 rs758992618 |
563 | G>C | No |
ClinGen gnomAD |
|
|
CA328094647 rs758992618 |
563 | G>R | No |
ClinGen gnomAD |
|
|
CA412628033 rs758992618 |
563 | G>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs1277200484 COSM612161 CA412628012 |
566 | D>N | lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
rs894073645 CA328094646 |
567 | H>D | No |
ClinGen TOPMed gnomAD |
|
|
CA412627988 rs1200177975 |
569 | A>D | No |
ClinGen TOPMed |
|
|
CA412627986 rs1200177975 |
569 | A>V | No |
ClinGen TOPMed |
|
| TCGA novel | 570 | E>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA412627928 rs1413297255 |
577 | L>S | No |
ClinGen gnomAD |
|
|
CA412627920 rs1602933578 |
578 | D>G | No |
ClinGen Ensembl |
|
|
rs1375113657 CA412627923 |
578 | D>H | No |
ClinGen TOPMed gnomAD |
|
|
rs1375113657 CA412627924 |
578 | D>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs1319267813 CA412627916 |
579 | E>K | No |
ClinGen gnomAD |
|
|
rs765295087 CA10375051 |
580 | S>F | No |
ClinGen ExAC gnomAD |
|
|
rs750984121 CA10375052 |
580 | S>T | No |
ClinGen ExAC gnomAD |
|
|
rs757330204 CA10375050 |
586 | T>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA412627865 rs1472264811 |
586 | T>I | No |
ClinGen gnomAD |
|
|
CA10375048 rs764318936 |
588 | E>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA412627856 rs1465260468 |
588 | E>G | No |
ClinGen TOPMed |
|
|
COSM457314 rs764318936 CA412627857 |
588 | E>K | kidney Variant assessed as Somatic; 0.0 impact. breast [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA10375047 rs759208081 |
589 | E>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10375045 rs750231027 |
590 | E>D | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA10375044 rs192364674 |
591 | G>A | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA328094645 rs192364674 |
591 | G>V | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA412627833 rs1602933518 |
592 | Q>K | No |
ClinGen Ensembl |
|
|
rs201455864 COSM1467360 CA328094644 |
594 | R>* | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
CA412627816 rs1281606992 |
594 | R>Q | No |
ClinGen gnomAD |
|
|
CA412627811 rs1270577970 |
595 | V>L | No |
ClinGen gnomAD |
|
|
CA412627794 rs1336171134 |
597 | C>Y | No |
ClinGen gnomAD |
|
|
CA10375043 rs773291515 |
598 | I>M | No |
ClinGen ExAC TOPMed gnomAD |
No associated diseases with A6NGE4
7 regional properties for A6NGE4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 185 - 224 | IPR001680-1 |
| repeat | WD40 repeat | 227 - 269 | IPR001680-2 |
| repeat | WD40 repeat | 278 - 315 | IPR001680-3 |
| repeat | WD40 repeat | 322 - 363 | IPR001680-4 |
| repeat | WD40 repeat | 372 - 418 | IPR001680-5 |
| repeat | WD40 repeat | 424 - 466 | IPR001680-6 |
| repeat | WD40 repeat | 469 - 509 | IPR001680-7 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| Cul4-RING E3 ubiquitin ligase complex | A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P0C7V8 | DCAF8L2 | DDB1- and CUL4-associated factor 8-like protein 2 | Homo sapiens (Human) | PR |
| Q58WW2 | DCAF6 | DDB1- and CUL4-associated factor 6 | Homo sapiens (Human) | PR |
| Q5TAQ9 | DCAF8 | DDB1- and CUL4-associated factor 8 | Homo sapiens (Human) | PR |
| Q9DC22 | Dcaf6 | DDB1- and CUL4-associated factor 6 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSHQEGSTGG | LPDLVTESLF | SSPEEQSGVA | AVTAASSDIE | MAATEPSTGD | GGDTRDGGFL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NDASTENQNT | DSESSSEDVE | LESMGEGLFG | YPLVGEETER | EEEEEEMEEE | GEEEEQPRMC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PRCGGTNHDQ | CLLDEDQALE | EWISSETSAL | PRSRWQVLTA | LRQRQLGSSA | RFVYEACGAR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TFVQRFRLQY | LLGSHAGSVS | TIHFNQRGTR | LASSGDDLRV | IVWDWVRQKP | VLNFESGHDI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NVIQAKFFPN | CGDSTLAMCG | HDGQVRVAEL | INASYCENTK | RVAKHRGPAH | ELALEPDSPY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KFLTSGEDAV | VFTIDLRQDR | PASKVVVTRE | NDKKVGLYTI | SMNPANIYQF | AVGGHDQFVR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IYDQRRIDKK | ENNGVLKKFT | PHHLVYCDFP | TNITCVVYSH | DGTELLASYN | DEDIYLFNSS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LSDGAQYVKR | YKGHRNNDTI | KCVNFYGPRS | EFVVSGSDCG | HVFFWEKSSS | QIIQFMEGDR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GDIVNCLEPH | PYLPVLATSG | LDQHVRIWTP | TAKTATELTG | LKDVIKKNKQ | ERDEDNLNYT |
| 550 | 560 | 570 | 580 | 590 | |
| DSFDNRMLRF | FVRHLLQRAH | QPGWRDHGAE | FPDEEELDES | SSTSDTSEEE | GQDRVQCIPS |