AiPD: Autoinhibited Protein Database

Gene name	Acadsb
Protein name	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
Names	SBCAD, 2-methyl branched chain acyl-CoA dehydrogenase, 2-MEBCAD, 2-methylbutyryl-coenzyme A dehydrogenase, 2-methylbutyryl-CoA dehydrogenase
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:66885
EC number	1.3.8.5: With a flavin as acceptor
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-71 (Predicted disordered autoinhibitory region) PR

1-71 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9DBL1-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388952813	11	M>I	No	EVA
rs3388937139	15	L>Q	No	EVA
rs238155827	18	R>S	No	EVA
rs3398656757	19	F>I	No	EVA
rs252233738	25	P>S	No	EVA
rs219592578	31	R>H	No	EVA
rs3388910052	36	S>P	No	EVA
rs3388957236	38	P>T	No	EVA
rs580005539	40	A>T	No	EVA
rs3388953809	41	L>Q	No	EVA
rs238790641	42	V>L	No	EVA
rs248500161	44	L>M	No	EVA
rs48904489	49	V>L	No	EVA
rs264511938	51	F>C	No	EVA
rs232394661	66	Q>K	No	EVA
rs3388956502	71	F>S	No	EVA
rs3398787046	76	V>C	No	EVA
rs3398413542	79	L>V	No	EVA
rs224317312	82	S>P	No	EVA
rs864295237	161	T>A	No	EVA
rs3388957313	185	S>P	No	EVA
rs252596261	210	H>N	No	EVA
rs582206219	215	E>D	No	EVA
rs586833939	245	Q>H	No	EVA
rs3398666573	245	Q>P	No	EVA
rs3398413543	269	K>N*	No	EVA
rs586251464	313	I>V	No	EVA
rs13461151	315	Y>H	No	EVA
rs3388956362	370	A>V	No	EVA
rs3388952812	418	N>I	No	EVA
rs3388957204	422	N>D	No	EVA

Type	Name	Position	InterPro Accession
conserved_site	Acyl-CoA dehydrogenase, conserved site	175 - 187	IPR006089-1
conserved_site	Acyl-CoA dehydrogenase, conserved site	387 - 406	IPR006089-2
domain	Acyl-CoA oxidase/dehydrogenase, middle domain	173 - 268	IPR006091
domain	Acyl-CoA dehydrogenase/oxidase C-terminal	280 - 428	IPR009075
domain	Acyl-CoA dehydrogenase/oxidase, N-terminal	58 - 168	IPR013786

		Description
EC Number	1.3.8.5	With a flavin as acceptor
Subcellular Localization	Mitochondrion matrix
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
mitochondrial matrix	The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

Name	Definition
2-methylacyl-CoA dehydrogenase activity	Catalysis of the reaction: 2-methylbutanoyl-CoA + H+ + oxidized = (2E)-2-methylbut-2-enoyl-CoA + reduced
acyl-CoA dehydrogenase activity	Catalysis of the reaction: acyl-CoA + oxidized
electron transfer activity	Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.
flavin adenine dinucleotide binding	Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
identical protein binding	Binding to an identical protein or proteins.
isobutyryl-CoA:FAD oxidoreductase activity	Catalysis of the reaction: H+ + isobutyryl-CoA + FAD <=> methacrylyl-CoA + FADH2.
short-branched-chain-acyl-CoA dehydrogenase activity	Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a short branched chain fatty acid residue.

Name	Definition
acyl-CoA metabolic process	The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group.
fatty acid beta-oxidation	A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
fatty acid metabolic process	The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
isoleucine catabolic process	The chemical reactions and pathways resulting in the breakdown of isoleucine, (2R,3R)-2-amino-3-methylpentanoic acid.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q3ZBF6	ACADS	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	Bos taurus (Bovine)	PR
P16219	ACADS	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	Homo sapiens (Human)	PR
Q07417	Acads	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	Mus musculus (Mouse)	PR
P50544	Acadvl	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	Mus musculus (Mouse)	PR
P79273	ACADS	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	Sus scrofa (Pig)	PR
P15651	Acads	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	Rattus norvegicus (Rat)	PR
P70584	Acadsb	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	Rattus norvegicus (Rat)	PR