Q3ZBF6
Gene name |
ACADS |
Protein name |
Short-chain specific acyl-CoA dehydrogenase, mitochondrial |
Names |
SCAD, Butyryl-CoA dehydrogenase |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:511222 |
EC number |
1.3.8.1: With a flavin as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3ZBF6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3ZBF6-F1 | Predicted | AlphaFoldDB |
No variants for Q3ZBF6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q3ZBF6 | |||||
No associated diseases with Q3ZBF6
1 regional properties for Q3ZBF6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Septin-type guanine nucleotide-binding (G) domain | 295 - 571 | IPR030379 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.3.8.1 | With a flavin as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrial matrix | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| acyl-CoA dehydrogenase activity | Catalysis of the reaction: acyl-CoA + oxidized |
| butyryl-CoA dehydrogenase activity | Catalysis of the reaction: butanoyl-CoA + electron-transfer flavoprotein = 2-butenoyl-CoA + reduced electron-transfer flavoprotein. |
| flavin adenine dinucleotide binding | Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| butyrate catabolic process | The chemical reactions and pathways resulting in the breakdown of butyrate, the anion of butyric acid. |
| fatty acid beta-oxidation using acyl-CoA dehydrogenase | A fatty acid beta-oxidation pathway in which the initial step of each oxidation cycle, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA dehydrogenase; the electrons removed by oxidation pass through the respiratory chain to oxygen and leave H2O as the product. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P48818 | ACADVL | Very long-chain specific acyl-CoA dehydrogenase, mitochondrial | Bos taurus (Bovine) | PR |
| P16219 | ACADS | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | Homo sapiens (Human) | PR |
| Q9DBL1 | Acadsb | Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial | Mus musculus (Mouse) | PR |
| Q07417 | Acads | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | Mus musculus (Mouse) | PR |
| P79273 | ACADS | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | Sus scrofa (Pig) | PR |
| P70584 | Acadsb | Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial | Rattus norvegicus (Rat) | PR |
| P15651 | Acads | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAATLLARAC | GLVRGAPWPW | GWRRLHTVYQ | SVELPETHQM | LRQTCRDFAE | KELFPIAAQV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DKEHRFPAAQ | VKKMGELGLM | AMNVPEELSG | AGLDYLAYSI | AMEEISRGCA | STGVIMSVNN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SLYLGPILKF | GTKEQKQQWV | APFTSGDKIG | CFALSEPGNG | SDAGAAATTA | RADGDSWVLS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GTKAWITNAW | EASAVVVFAS | TDRSLHNKGI | SAFLVPMPTP | GLTLGKKEDK | LGIRASSTAN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LIFEDRRIPK | DSLLGEPGLG | FKIAMQTLDT | GRIGIASQAL | GIAQAALDCA | VTYAENRSAF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GAPLTKLQAI | QFKLADMALA | LESARLLTWR | AAMLKDNKKP | FTKEAAMAKL | AASEAATAIT |
| 370 | 380 | 390 | 400 | 410 | |
| HQAMQILGGM | GYVKEMPAER | HYRDARITEI | YEGTSEIQRL | VVAGHLLKSY | RS |